Results 211 to 220 of about 743,554 (284)

Denoise Stepwise Signals by Diffusion Model‐Based Approach

Small Methods, EarlyView.
This work presents SSDM, a diffusion‐model‐based framework for denoising stepwise signals in single‐molecule measurements. By learning the statistical structure of state transitions and noise, SSDM reconstructs signal levels and identifies transition time points more accurately than conventional approaches, enabling robust analysis of signals across ...
Xingdi Tong, Chenyu Wen
wiley   +1 more source

Nanopore sequencing identifies parent-of-origin specific age-associated methylation changes at imprinted loci in the human genome. [PDF]

Nat Commun
Sigurpalsdottir B, Holley G, Sverrisson SÞ, Magnusdottir DN, Olafsson PI, Gylfason A, Magnusson OÞ, Masson G, Stefansson OA, Halldorsson BV.   +9 more
europepmc   +1 more source

Peptide Fingerprinting of Single Protein Molecules Using In‐Plane Nanopore Sensors Integrated to an Extended Immobilized Nanoscale Enzymatic Reactor (eINER)

Small Methods, EarlyView.
The protein Time‐of‐Flight (P‐ToF) chip can peptide fingerprint a single protein molecule by subjecting it to a solid phase endopeptidase cleavage reaction in‐line with a combination of resistive pulse sensing of the resulting single peptides and machine‐learning aided identification.
Suresh Shivanka, Randy F. Espinal Cabrera, Maximillian Chibuike, Pramodi Vithanage, Indu A. Chandrasoma, Pubudu Premarathne, Matthew Verber, Steven A. Soper   +7 more
wiley   +1 more source

Simultaneous detection of thalassemia, hemoglobinopathies, and G6PD variants using long-read nanopore sequencing: genetic complexity and heterogeneity in Thailand. [PDF]

PeerJ
Rujirachaivej P, Phermthong P, Rattanakoch P, Treeravatananon L, Saelee N, Chaweewattanaskul S, Boonlikit S, Koyvanich A, Panyasai S, Karnpean R, Jomoui W.   +10 more
europepmc   +1 more source

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

VIEW, EarlyView.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder, Kacy Greenhalgh, Joanna Baginska, Camille Martin‐Gallausiaux, Léa Grandmougin, Rémy Villette, Mara Lucchetti, Bérénice Hansen, Marek Ostaszewski, Viacheslav A. Petrov, Koji Atarashi, Lena Weidert, Audrey Frachet Bour, Dominik Ternes, Javier Ramiro‐Garcia, Antoine Malabirade, Takeshi Tanoue, Marc Mac Giolla Eain, Elisabeth Letellier, Matthew Barrett, Jérôme Lacombe, Frederic Zenhausern, Coralie Guérin, Markus Ollert, Carole Seguin‐Devaux, Kenya Honda, Paul Wilmes   +26 more
wiley   +1 more source

Development of a Multiplex Amplification System Using Oxford Nanopore Sequencing for STRs and InDels. [PDF]

Hum Mutat
Han W, Zhang Q, Zhang X, Feng M, Xu H, Geng X, Wang Y, Zhou Z.   +7 more
europepmc   +1 more source

Plant‐derived nanovesicles as potential drug delivery systems for topical use: Emerging applications in dermatology and cosmetology

VIEW, EarlyView.
Plant‐derived nanovesicles (PDNVs) are naturally secreted by fruit, vegetables, seeds, leaves and other natural sources. Used as drug delivery systems, they can combine intrinsic therapeutic activity, enhanced skin permeation and cargo‐carrying capacity, suitable for dermatological and cosmetic applications including hydration, antioxidant/anti ...
Dorotea Fiore, Beatrice Pellegrini, Antonia Mancuso, Maria Chiara Cristiano, Salvatore Panza, Donatella Paolino   +5 more
wiley   +1 more source

Filtering of artificial chimeric reads generated by ligation preparation method of nanopore sequencing. [PDF]

iScience
Xie Z, Zhang J, Yang T, Bo X, Fu Z, Yang F, Ye F, Ni M.   +7 more
europepmc   +1 more source

Comparative Analysis of Stress Adaptation in the Yeast Microbiome of Cactus

Yeast, EarlyView.
Yeasts and related fungi isolated from cacti or nearby non‐cactus plants were characterized phenotypically and genomically, revealing differences that hint at modes of adaptation to the cactus host. ABSTRACT Together with other fungi, yeasts make up a significant component of the plant microbiome. As the planet warms, cacti expand their range.
Alya N. Hussain, Kevin T. Fotso, Michael A. McMurray   +2 more
wiley   +1 more source

Assessing the readiness of Oxford Nanopore sequencing for clinical genomics applications. [PDF]

Genome Res
Arres J, Elavalli S, Behl S, Matias Sanchez D, Al Ali A, Saad AAYA, Attia A, Minas C, Pariyachery S, Ahmed S, Aldhuhoori F, Thulasidharan N, Katagi G, Soliman O, Purohit S, Kusuma V, Cardenas R, Cardoso T, Paulin LF, Sanio P, Mafofo J, Wu H, Zvereff V, El-Khani A, Al Marzooqi F, Magalhães TR, Sedlazeck FJ, Quilez J.   +27 more
europepmc   +1 more source