Results 131 to 140 of about 110,323 (165)
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Molecular Biology Reports, 2012
A sodium-dependent phosphate transporter gene, NaPi-IIb, was isolated from swine small intestine using cDNA library screening method. Sequencing analysis revealed that the NaPi-IIb cDNA sequences was 2,016 bp in length and encoded an open-reading frame consisting of 671 amino acids. The cDNA showed 83.1 % sequences identity to the human NaPi-IIb and 78.
Xiang Zhifeng
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A sodium-dependent phosphate transporter gene, NaPi-IIb, was isolated from swine small intestine using cDNA library screening method. Sequencing analysis revealed that the NaPi-IIb cDNA sequences was 2,016 bp in length and encoded an open-reading frame consisting of 671 amino acids. The cDNA showed 83.1 % sequences identity to the human NaPi-IIb and 78.
Xiang Zhifeng
exaly +5 more sources
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2004 Serum and glucocorticoid-inducible kinase 1 (SGK1) is highly expressed in enterocytes. The significance of the kinase in regulation of intestinal function has, however, remained elusive. In Xenopus laevis oocytes, SGK1 stimulates the epithelial Na+ channel by phosphorylating the ubiquitin ligase Nedd4–2, which regulates channels by ubiquitination ...
M. Palmada +11 more
semanticscholar +4 more sources
Journal of Urology, 2019
available at http://www.ncbi.nlm.nih.gov/pubmed/30542787 Editorial Comment: The majority of phosphate reabsorption in the kidney occurs in the proximal tubule.
D. Assimos
semanticscholar +3 more sources
available at http://www.ncbi.nlm.nih.gov/pubmed/30542787 Editorial Comment: The majority of phosphate reabsorption in the kidney occurs in the proximal tubule.
D. Assimos
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Upregulation of the Na+-Coupled Phosphate Cotransporters NaPi-IIa and NaPi-IIb by B-RAF
The Journal of Membrane Biology, 2014B-RAF, a serine/threonine protein kinase, contributes to signaling of insulin-like growth factor IGF1. Effects of IGF1 include stimulation of proximal renal tubular phosphate transport, accomplished in large part by Na⁺-coupled phosphate cotransporter NaPi-IIa. The related Na⁺-coupled phosphate cotransporter NaPi-IIb accomplishes phosphate transport in
Tatsiana Pakladok +4 more
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Downregulation of NaPi-IIa and NaPi-IIb Na+-coupled Phosphate Transporters by Coexpression of Klotho [PDF]
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2011 Klotho, a transmembrane protein, protease and hormone has been shown to exert a profound effect on phosphate metabolism. Klotho overexpression lowers and Klotho deficiency increases the plasma phosphate concentration, effects in part attributed to an inhibitory effect of Klotho on the formation of 1,25-dihydroxycholecalciferol (1,25(OH) (2)D(3)), the ...
M. Dërmaku-Sopjani +7 more
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Transcriptional regulation of the human NaPi-IIb cotransporter by EGF in Caco-2 cells involves c-myb
American Journal of Physiology - Cell Physiology, 2003Eric R Hines, James F Collins
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Pflügers Archiv - European Journal of Physiology, 2018
Hyperphosphatemia is a common condition in patients with chronic kidney disease (CKD) and can lead to bone disease, vascular calcification, and increased risks of cardiovascular disease and mortality. Inorganic phosphate (Pi) is absorbed in the intestine, an important step in the maintenance of homeostasis.
T. Aniteli +7 more
semanticscholar +4 more sources
Hyperphosphatemia is a common condition in patients with chronic kidney disease (CKD) and can lead to bone disease, vascular calcification, and increased risks of cardiovascular disease and mortality. Inorganic phosphate (Pi) is absorbed in the intestine, an important step in the maintenance of homeostasis.
T. Aniteli +7 more
semanticscholar +4 more sources
Profiling Sodium-Dependent Phosphate Transporter NaPi-IIb with Resonant Waveguide Grating Biosensor
, 2015Soo-Hang Wong, Alice Gao, Paul H. Lee
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Biochemical and Biophysical Research Communications, 2009
NaPi-IIb encodes a Na(+)-dependent Pi co-transporter, which is expressed in various adult tissues and mediates transport of extracellular Pi ions coupling with Na(+) ion. To define the role of NaPi-IIbin vivo, NaPi-IIb gene deficient mice were generated utilizing targeted mutagenesis, yielding viable, heterozygous NaPi-IIb mice. In contrast, homozygous
Y. Shibasaki +7 more
semanticscholar +3 more sources
NaPi-IIb encodes a Na(+)-dependent Pi co-transporter, which is expressed in various adult tissues and mediates transport of extracellular Pi ions coupling with Na(+) ion. To define the role of NaPi-IIbin vivo, NaPi-IIb gene deficient mice were generated utilizing targeted mutagenesis, yielding viable, heterozygous NaPi-IIb mice. In contrast, homozygous
Y. Shibasaki +7 more
semanticscholar +3 more sources
American Journal of Physiology-Gastrointestinal and Liver Physiology, 2005
The human intestinal type IIb Na+-Picotransporter (hNaPi-IIb) gene promoter lacks a TATA box and has a high GC content in the 5′-flanking region. To understand the mechanism of hNaPi-IIb gene transcription, the current study was performed to characterize the minimal promoter region and transcriptional factor(s) necessary to activate gene expression in ...
Hua Xu +4 more
semanticscholar +3 more sources
The human intestinal type IIb Na+-Picotransporter (hNaPi-IIb) gene promoter lacks a TATA box and has a high GC content in the 5′-flanking region. To understand the mechanism of hNaPi-IIb gene transcription, the current study was performed to characterize the minimal promoter region and transcriptional factor(s) necessary to activate gene expression in ...
Hua Xu +4 more
semanticscholar +3 more sources