Results 91 to 100 of about 20,829 (242)

The emerging role of CAMK1D in diabetes, metabolism and feeding behaviours: A mechanistic systematic review

Clinical and Translational Discovery, Volume 6, Issue 1, February 2026.
This systematic review synthesizes evidence from published studies, GWAS and grey literature (patents) to show that CAMK1D is implicated in diabetes, obesity, insulin resistance and altered feeding behaviours, with diagnostic potential and mechanistic relevance through regulatory binding and tissue‐specific effects.
Livio Tarchi, Annalisa Di Giacomo, Lorenzo Bonacchi, Andrea Di Santo, Paolo Rovero, Chiara Sassoli, Rachele Garella, Roberta Squecco, Gianluca Villa, Romina Nassini, Francesco De Logu, Tiziana Pisano, Valdo Ricca, Giovanni Castellini   +13 more
wiley   +1 more source

Increased chin muscle tone during all sleep stages in children taking selective serotonin reuptake inhibitor antidepressants and in children with narcolepsy type 1 [PDF]

, 2021
Raffaele Ferri, Maria P. Mogavero, Oliviero Bruni, Giuseppe Plazzi, Carlos H. Schenck, Lourdes M. DelRosso   +5 more
openalex   +1 more source

Microbial‐Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies

European Journal of Immunology, Volume 56, Issue 2, February 2026.
Mechanism of action of the intestinal microbiota on CNS autoimmune diseases. Environmental factors shape gut microbiota composition; dysbiosis alters microbial metabolites and antigenic signals. These modulate innate and adaptive immunity, affect barrier integrity, and influence CNS‐resident cells such as microglia and astrocytes, contributing to ...
Matteo Ceccon, Francesca Ronchi
wiley   +1 more source

Pharmacological MRI: Utility in Understanding Drug Mechanisms in Psychiatric Disorders

Journal of Magnetic Resonance Imaging, Volume 63, Issue 2, Page 346-363, February 2026.
ABSTRACT Pharmacological MRI (pharmaMRI) has emerged as a powerful tool to study how psychoactive drugs affect brain function and to uncover mechanisms of drug action in psychiatric disorders. This review provides an overview of key techniques used in pharmaMRI, including BOLD‐fMRI, arterial spin labeling (ASL), and cerebral blood volume (CBV) mapping,
Christin Y. Sander, Tudor M. Ionescu, Mitul A. Mehta, Ottavia Dipasquale, Anouk Schrantee   +4 more
wiley   +1 more source

Estimation of the Orexin Receptor Occupancy From Human Plasma Pharmacokinetics of Vornorexant, a Novel Dual Orexin 1/2 Receptor Antagonist for the Treatment of Insomnia

Pharmacology Research &Perspectives, Volume 14, Issue 1, February 2026.
ABSTRACT Vornorexant is a novel dual orexin receptor antagonist (DORA) for the treatment of insomnia with a short elimination half‐life. Estimation of the human orexin receptor occupancy can provide insight into the duration of the sleep‐promoting effect of DORAs.
Shunsuke Kamigaso, Yoshihiro Konno, Hirohiko Hikichi, Daiji Kambe, Yoko Mano, Yuichi Tokumaru, Haruyuki Mori, Hironori Yamasaki, Yukihiro Chino, Kenji Hachiuma, Akiko Mizuno‐Yasuhira   +10 more
wiley   +1 more source

Emergency department presentations, hospitalisations and police seizure data related to gamma‐hydroxybutyrate (GHB) in New South Wales, Australia, from 2015 to 2024

Addiction, Volume 121, Issue 2, Page 305-315, February 2026.
Abstract Background and aims Gamma‐hydroxybutyrate (GHB) is an endogenous neurochemical and illicit synthetic drug. Its precursors, gamma‐butyrolactone (GBL) and 1,4‐butanediol (1,4‐BD), are often used as substitutes. We aimed to describe GHB‐related harms in New South Wales (NSW), Australia.
Krista J. Siefried, Janette L. Smith, Christine A. Harvey, Anthony Nedanoski, Jared A. Brown, Una Cullinan, Nadine Ezard, Thanjira Jiranantakan, Darren M. Roberts, Jonathan Brett   +9 more
wiley   +1 more source

Narcolepsy Is Associated With Subclinical Cardiovascular Disease as Early as Childhood: A Big Data Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Narcolepsy is linked to adverse cardiovascular disease (CVD) outcomes, but few studies have examined its associations with subclinical CVD, including in children.
Christopher N. Kaufmann, Munaza Riaz, Haesuk Park, Wei‐Hsuan Lo‐Ciganic, Debbie Wilson, Emerson M. Wickwire, Atul Malhotra, Rakesh Bhattacharjee   +7 more
doaj   +1 more source

0759 Phase 2 Proof Of Concept Study Of SUVN-G3031, A Histamine H3 Receptor Inverse Agonist For The Potential Treatment Of Narcolepsy [PDF]

, 2020
Ramakrishna Nirogi, Vinod Goyal, Pradeep Jayarajan, Gopinadh Bhyrapuneni, Jyothsna Ravula, S. Jetta, A. Shinde   +6 more
openalex   +1 more source

Impact of Symptoms of Neuromyelitis Optica Spectrum Disorder and Patient‐Determined Oral Glucocorticoid–Related Adverse Events on Patients' Daily Living and Emotions: A Qualitative Analysis From Japan

Clinical and Experimental Neuroimmunology, Volume 17, Issue 1, February 2026.
ABSTRACT Background and Objectives Neuromyelitis optica spectrum disorder (NMOSD) is a chronic disorder with a relapsing–remitting disease course that impacts patients' quality of life. Oral glucocorticoids (OGCs) have been the standard of care for NMOSD in Japan; however, their chronic use is associated with adverse events (AEs).
Yuko Shimizu, Ichiro Nakashima, Ryotaro Ikeguchi, Tadashi Nagatsuka, Katsuhisa Yamashita, Yuta Fukuoka, Tatsunori Murata, Kazuo Fujihara   +7 more
wiley   +1 more source

Development of the pediatric narcolepsy patient-reported outcomes scale (PN-PROs)

Frontiers in Sleep
BackgroundPediatric narcolepsy is a chronic neurological disorder that impacts the health and overall wellbeing of children and adolescents with the disease.
Grace Y. Wang, Jennifer Worhach, Eric S. Zhou, Eric S. Zhou, Michael Strunc, Anne M. Morse, Judith A. Owens, Julie Flygare, Anna Revette, Lisa J. Meltzer, Kiran Maski   +10 more
doaj   +1 more source