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Narcotic Antagonists as Analgesics
Science, 19622-Dimethylallyl-5,9-dimethyl-2′-hydroxybenzomorphan (Win 20,228) was found to be a weak antagonist of morphine and meperidine, whereas 2-allyl-5-ethyl-2′-hydroxy-9-methyl-6,7-benzomorphan (Win 19,362) and 2-allyl-2′-hydroxy-5,9-dimethyl-6,7-benzomorphan (Win 19,631) were about three times as potent as nalorphine.
S, ARCHER +7 more
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STRUCTURAL FEATURES ASSOCIATED WITH NARCOTICS AND NARCOTIC ANTAGONISTS
Neuropharmacology, 1975Viminol shares many pharmacological properties of the traditional narcotics, but it differs from the latter because it has an extremely reduced capacity for producing physical dependence. This chapter discusses the types of pharmacological activity related to the structural features of the Viminol stereoisomers.
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COMPARATIVE STUDIES WITH NARCOTICS AND NARCOTIC ANTAGONISTS IN MAN
Acta Anaesthesiologica Scandinavica, 1964ZUSAMMENFASSUNGBei 240 oberflächlich anaesthesierten Patienten, die keine Narkotika als Prämedikation erhalten hatten, wurden die Wirkungen auf Atmung und Kreislauf der folgenden Mittel, allein oder in verschiedenen Kombinationen verabreicht, untersucht: Morphin (0,2 oder 0,3 mg/kg), Oxymorphon(20 μ/kg),Levorphan (50μ/kg),Meperidin (1,5 und 2,0 mg/kg ...
F F, FOLDES, T A, TORDA
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EVALUATION OF NARCOTIC AND NARCOTIC ANTAGONIST INTERACTIONS IN PRIMATES*
Annals of the New York Academy of Sciences, 1976Multiple and single drug interactions were studied in morphine-dependent monkeys whose dependency was maintained by self-infusion. Naloxone, naltrexone, and cyclazocine precipitated abstinence syndrome which the animals generally controlled with increased morphine intake.
K F, Killam, M J, Brocco, C A, Robinson
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Studies on the Specificity of Narcotic Antagonists
Anesthesiology, 1965Experiments with five narcotics, (morphine 0.3 mg./kg., oxymorphone 20 μg./kg., levorphan 50 μg./kg., meperidine 1.5 μg./kg. and fentanyl 1.5 μ./kg.) and three narcotic antagonists (nalorphine 150 μg./kg., naloxone 5 μg./kg., and levallorphan 20 μg./kg.
F F, FOLDES +4 more
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, 2013 Clinical Principles for the Narcotic Antagonists
Postgraduate Medicine, 1957(1957). Clinical Principles for the Narcotic Antagonists. Postgraduate Medicine: Vol. 22, No. 6, pp. 566-571.
M S, SADOVE, M J, SCHIFFRIN
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CLINICAL PHARMACOLOGY OF NARCOTIC ANTAGONISTS*
Annals of the New York Academy of Sciences, 1978Both naloxone and naltrexone are effective narcotic antagonists with minimal agonistic effects and a wide margin of safety. Naloxone is useful in the treatment of narcotic overdose and it is helpful in the quantification of physical dependence. Naltrexone is pharmacologically successful as an orally effective, long-acting antagonist but its clinical ...
C P, O'Brien +3 more
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