A Theory of Natural Addiction [PDF]
Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Ainslie+102 more
core +1 more source
Counteraction of Narcotic Antagonist Analgesics by the Narcotic Antagonist Naloxone
SummaryWhen the potent narcotic antagonist, naloxone, was injected subcutane-ously into mice and rats simultaneously with narcotic antagonist analgesics, naloxone counteracted the writhing test analgesic activity of the antagonists. Naloxone completely antagonized the potent analgesic activity of pentazocine, nalorphine, cyclazocine, and cy-clorphan ...
Harold Blumberg+2 more
openaire +3 more sources
A Research Evaluation OF THE RATIO OF NARCOTIC TO NARCOTIC ANTAGONIST
Phillip S. Marcus+2 more
+5 more sources
Evaluation of butorphanol, medetomidine and midazolam as a reversible narcotic combination in free-ranging African lions (Panthera leo) [PDF]
Objective To evaluate the effects of the combination butorphanol, medetomidine and midazolam (BMM) and its reversibility in lions. Study design Prospective clinical trial.
Bush+37 more
core +1 more source
Interactions of narcotic antagonists and antagonist-analgesics
Abstract In the rat the potent narcotic antagonist N-cyclopropylmethyl-6,14-endoethano-7α- (1-hydroxy-1-methylethyl)-tetrahydronororipavine (M5050, Reckitt), which itself lacks analgesic activity, resembled naloxone in its capacity to reverse the antinociceptive effects of morphine antagonist-analgesics. The nociceptive stimulus employed
G F Blane, D Dugdall
openaire +3 more sources
The Efficacy of Peripheral Opioid Antagonists in Opioid-Induced Constipation and Postoperative Ileus: A Systematic Review of the Literature. [PDF]
Opioid-induced constipation has a negative impact on quality of life for patients with chronic pain and can affect more than a third of patients. A related but separate entity is postoperative ileus, which is an abnormal pattern of gastrointestinal ...
Baratta, Jaime L.+5 more
core +1 more source
Identification of Tetrahydrocannabidiol Metabolites in Human Urine
The detection of Phase I and II metabolites of tetrahydrocannabidiol (H4CBD) in urine after oral ingestion of 25‐mg H4CBD by a volunteer is described. The proposed metabolite structures are based on ESI+ spectra recorded by HPLC‐HRMS and EI spectra after trimethylsilylation recorded by GC–MS.
Willi Schirmer+3 more
wiley +1 more source
Former heroin-dependent alcohol use disorder patients. prevalence, addiction history and clinical features [PDF]
Aims: To examine the prevalence of former heroin dependence (FHA) in Alcohol Use Disorder (AUD) patients; to compare the clinical characteristics of FHA-AUD patients versus AUD patients without any past use of heroin at alcohol treatment entry; to ...
Ceccanti, Mauro+3 more
core +1 more source
Hidden Costs of Ban the Box Laws: Unraveling the Effects on Drug‐Related Deaths
ABSTRACT Ban the Box (BTB) laws delay criminal background checks until the later stages of the hiring process. This study provides new evidence that BTB laws that apply to both private and public employers have negative spillover effects beyond labor market outcomes.
Oleksandra Cheipesh
wiley +1 more source
Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity [PDF]
Background: Nor-BNI, GNTI and JDTic induce κ opioid antagonism that is delayed by hours and can persist for months. Other effects are transient. It has been proposed that these drugs may be slowly absorbed or distributed, and may dissolve in cell ...
Beguin, Cecile Andree+7 more
core +1 more source