Biodegradable polymeric prodrugs of naltrexone [PDF]
The development of a biodegradable polymeric drug delivery system for the narcotic antagonist naltrexone may improve patient compliance in the treatment of opiate addiction. Random copolymers consisting of the ¿-amino acids N5-(3-hydroxypropyl--glutamine
Adams, N.W.+5 more
core +2 more sources
A Theory of Natural Addiction [PDF]
Economic theories of rational addiction aim to describe consumer behavior in the presence of habit-forming goods. We provide a biological foundation for this body of work by formally specifying conditions under which it is optimal to form a habit.
Ainslie+102 more
core +1 more source
Swedish police officers' strategies when interviewing suspects who decline to answer questions
Abstract Purpose Research‐based interviewing techniques typically rely upon suspects being, at least partially, responsive and engaged in the conversation. To date, the scientific literature is more limited regarding situations where suspects exercise their legal right to silence.
Mikaela Magnusson+4 more
wiley +1 more source
Intranasal versus Intramuscular/Intravenous Naloxone for Pre-hospital Opioid Overdose: A Systematic Review and Meta-analysis [PDF]
Context: The present systematic review and meta-analysis aims to perform an extensive search in databases to compare the efficacy of the intranasal administration of naloxone with its intramuscular/intravenous administration in the pre-hospital ...
Amiri, Marzieh+6 more
core +5 more sources
Counteraction of Narcotic Antagonist Analgesics by the Narcotic Antagonist Naloxone
SummaryWhen the potent narcotic antagonist, naloxone, was injected subcutane-ously into mice and rats simultaneously with narcotic antagonist analgesics, naloxone counteracted the writhing test analgesic activity of the antagonists. Naloxone completely antagonized the potent analgesic activity of pentazocine, nalorphine, cyclazocine, and cy-clorphan ...
Harold Blumberg+2 more
openaire +3 more sources
Beyond “Making Poland Great Again.” Nostalgia in Polish Populist and Non‐populist Discourses1
Nostalgia can be triggered not only by personal recollections but also by exposure to narratives or images evoking desirable pasts, more or less fictional, and inducing feelings of longing for them. We analyze the institutional and semiotic machinery involved in the cultural construction of nostalgia in Poland and its role in generating sentiments that
Marta Kotwas, Jan Kubik
wiley +1 more source
Interactions of narcotic antagonists and antagonist-analgesics
Abstract In the rat the potent narcotic antagonist N-cyclopropylmethyl-6,14-endoethano-7α- (1-hydroxy-1-methylethyl)-tetrahydronororipavine (M5050, Reckitt), which itself lacks analgesic activity, resembled naloxone in its capacity to reverse the antinociceptive effects of morphine antagonist-analgesics. The nociceptive stimulus employed
G F Blane, D Dugdall
openaire +3 more sources
Opioid stimulation in the ventral tegmental area facilitates the onset of maternal behavior in rats [PDF]
This research investigated the effect of an increase or decrease in opioid activity in the ventral tegmental area (VTA) on the onset of maternal behavior in rats.
Kristal, Mark B., Thompson, Alexis C.
core +1 more source
Central and peripheral mechanisms of narcotic antitussives: codeine-sensitive and -resistant coughs [PDF]
Narcotic antitussives such as codeine reveal the antitussive effect primarily via the μ-opioid receptor in the central nervous system (CNS). The κ-opioid receptor also seems to contribute partly to the production of the antitussive effect of the drugs ...
Shirasaki, Tetsuya, Takahama, Kazuo
core +2 more sources
Selective review and commentary on emerging pharmacotherapies for opioid addiction. [PDF]
Pharmacotherapies for opioid addiction under active development in the US include lofexidine (primarily for managing withdrawal symptoms) and Probuphine®, a distinctive mode of delivering buprenorphine for six months, thus relieving patients, clinicians,
Ling, Walter+5 more
core +2 more sources