Results 31 to 40 of about 560,117 (294)

Identification of Tetrahydrocannabidiol Metabolites in Human Urine

Drug Testing and Analysis, EarlyView.
The detection of Phase I and II metabolites of tetrahydrocannabidiol (H4CBD) in urine after oral ingestion of 25‐mg H4CBD by a volunteer is described. The proposed metabolite structures are based on ESI+ spectra recorded by HPLC‐HRMS and EI spectra after trimethylsilylation recorded by GC–MS.
Willi Schirmer, Isabelle Mösch, Stefan Schürch, Wolfgang Weinmann   +3 more
wiley   +1 more source

Long-acting κ opioid antagonists nor-BNI, GNTI and JDTic: pharmacokinetics in mice and lipophilicity [PDF]

, 2012
Background: Nor-BNI, GNTI and JDTic induce κ opioid antagonism that is delayed by hours and can persist for months. Other effects are transient. It has been proposed that these drugs may be slowly absorbed or distributed, and may dissolve in cell ...
Beguin, Cecile Andree, Berry, Loren M, Carlezon, William A., Carroll, F Ivy, Cohen, Bruce Michael, Munro, Thomas A, Van't Veer, Ashlee Victoria, Zhao, Zhiyang   +7 more
core   +1 more source

Prevalence of AAS‐Positive Samples at Drug Abuse Laboratory Sweden Between 2014 and 2023 and Sub‐Study of Dual Use of AAS and Narcotics

Drug Testing and Analysis, EarlyView.
Throughout 2014–2023, over 20,000 AAS analyses have been conducted at the drug of abuse laboratory, Karolinska University Hospital. Approximately 20% and 2% of the samples have been positive for AAS, with no trends of increase or decrease. Around 50% of the AAS‐positive samples were also positive for narcotics (year 2022–2023), with gender differences;
Kim Petterson Bohlin, Tomas Villén, Oscar Hopcraft, Anton Pohanka, Lena Ekström   +4 more
wiley   +1 more source

Amniotic-Fluid Ingestion Enhances\ud Morphine Analgesia During Morphine\ud Tolerance and Withdrawal in Rats [PDF]

, 1991
Ingestion of placenta and amniotic fluid has been shown to enhance opioid-mediated analgesia in rats produced by morphine injection. footshock, vaginal/cervical stimulation, and during late pregnancy.
Doerr, Jean C., Kristal, Dr. Mark B.
core  

Selective review and commentary on emerging pharmacotherapies for opioid addiction. [PDF]

, 2011
Pharmacotherapies for opioid addiction under active development in the US include lofexidine (primarily for managing withdrawal symptoms) and Probuphine®, a distinctive mode of delivering buprenorphine for six months, thus relieving patients, clinicians,
Ling, Walter, Miotto, Karen, Mooney, Larissa, Nielsen, Suzanne, Torrington, Matthew, Zhao, Min   +5 more
core   +2 more sources

Effects of integrated programs for substance‐involved mothers on infant and child development outcomes: A systematic review and meta‐analysis

Infant Mental Health Journal: Infancy and Early Childhood, EarlyView.
Abstract Maternal substance use is a pressing public health issue that confers risk for maternal health, the parent‐infant relationship, and child development. Integrated interventions that jointly address maternal substance use and child development have shown promise for enhancing child outcomes.
Sophie Barriault, Mary Motz, Lamia Firasta, Hannah McDowell, Patrick R. Labelle, Nancy Poole, Nicole Racine   +6 more
wiley   +1 more source

Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]

, 1995
Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core   +1 more source

Memantine increases NMDA receptor level in the prefrontal cortex but fails to reverse apomorphine-induced conditioned place preference in rats [PDF]

, 2018
Studies have shown that inflammation and neurodegeneration may accompany the development of addiction to apomorphine and that the glutamate NMDA receptor antagonist, memantine, may be neuroprotective.
Baxter BL, Gluckman MI, Stein L, et al., Bisaga A, Comer SD, Ward AS, et al., Campbell JC, Jeyamohan SB, De LCP, et al., Chen G, Greengard P, Yan Z, Chen SL, Tao PL, Chu CH, et al., Di CP, Everitt BJ, Dos SER, Daval J, Koziel V, et al., El-Bachá RS, Netter P, Minn A, Haleem DJ, Ikram H, Haleem MA, Kelley AE, Kemp JA, Mckernan RM, Overton PG, Clark D, Papp M, Parsons CG, Popik P, Layer RT, Skolnick P, Popik P, Skolnick P, Popik P, Wrobel M, Bisaga A, Sam E, Verbeke N, Sattler R, Tymianski M, Singh N, Pillay V, Choonara YE, Spyraki C, Fibiger HC, Phillips AG, Téllez C, Bustamante ML, Toro P, et al., Uys JD, Lalumiere RT, Van dKD, Swerdlow NR, Koob GF, Volkow ND, Fowler JS, Wang GJ, et al., Wu PH, Mihic SJ, Liu JF, et al., Zweifel LS, Argilli E, Bonci A, et al.   +26 more
core   +2 more sources

Reimagining Urban River Bathing in Europe: A Multisectoral and Interdisciplinary Dive Into Lyon's Rivers (France)

River Research and Applications, EarlyView.
ABSTRACT Urban river bathing is re‐emerging across Europe, driven by social demand and climate change impacts. The Urban Bathing Consortium, an interdisciplinary and intersectoral consortium initiated at the University of Lyon (France), is at the forefront of studying the challenges and opportunities of creating and managing healthy, safe, and ...
Yixin Cao, Patrice Barbiero, François Briat, Benoit Camenen, Frédéric Chambat, Victoria Chiu, Benoit Cournoyer, Magali Delavenne, Benjamin Dewals, Marie Epain, Anne Honegger, Jérôme Le Coz, Gislain Lipeme Kouyi, Célia Maghakian, Oldrich Navratil, Olivier Pillonel, Marion Porcherie, Sara Puijalon, Nicolas Riviere, Marie‐Florence Thomas, Richard Trillat, Laurence Volatier, Jean‐Marie Zanot   +22 more
wiley   +1 more source

Flexor Reflex Decreases during Sympathetic Stimulation in Chronic Human Spinal Cord Injury [PDF]

, 2009
A better understanding of autonomic influence on motor reflex pathways in spinal cord injury is important to the clinical management of autonomic dysreflexia and spasticity in spinal cord injured patients.
Garrison, Mark Kevin, Schmit, Brian D.
core   +2 more sources