Abstract Maternal substance use is a pressing public health issue that confers risk for maternal health, the parent‐infant relationship, and child development. Integrated interventions that jointly address maternal substance use and child development have shown promise for enhancing child outcomes.
Sophie Barriault+6 more
wiley +1 more source
Nitrous Oxide: Mechanism of Its Antinociceptive Action [PDF]
Nitrous oxide (N2O) is an anesthetic gas known to produce an analgesic effect at sub-anesthetic concentrations. This analgesic property of N2O can be clinically exploited in a broad range of conditions where pain relief is indicated.
Quock, Raymond M., Vaughn, Linda K.
core +1 more source
Memantine increases NMDA receptor level in the prefrontal cortex but fails to reverse apomorphine-induced conditioned place preference in rats [PDF]
Studies have shown that inflammation and neurodegeneration may accompany the development of addiction to apomorphine and that the glutamate NMDA receptor antagonist, memantine, may be neuroprotective.
Baxter BL, Gluckman MI, Stein L, et al.+26 more
core +2 more sources
ABSTRACT Black/African Americans with disabilities who live with substance use disorder and/or serious mental illness are an underserved population in mental health treatment. We conducted a quantitative analysis using the 2022 National Survey on Drug Use and Health (N = 317) to identify treatment trends and interpreted results using DisCrit and the ...
Jennifer M. Cook+4 more
wiley +1 more source
Amniotic-Fluid Ingestion Enhances\ud Morphine Analgesia During Morphine\ud Tolerance and Withdrawal in Rats [PDF]
Ingestion of placenta and amniotic fluid has been shown to enhance opioid-mediated analgesia in rats produced by morphine injection. footshock, vaginal/cervical stimulation, and during late pregnancy.
Doerr, Jean C., Kristal, Dr. Mark B.
core
Selective review and commentary on emerging pharmacotherapies for opioid addiction. [PDF]
Pharmacotherapies for opioid addiction under active development in the US include lofexidine (primarily for managing withdrawal symptoms) and Probuphine®, a distinctive mode of delivering buprenorphine for six months, thus relieving patients, clinicians,
Ling, Walter+5 more
core +2 more sources
State Capture—Institutionalized Corruption of the South African Revenue Service
ABSTRACT This study provides valuable insight for scholars, practitioners, and government officials on how a local office of a respected international consulting firm became associated with allegations of illicit influence and state capture. The article presents how political and business leaders used a government agency, the South African Revenue ...
Jennifer H. Heckel, Prescott C. Ensign
wiley +1 more source
A Randomized, Blinded, Placebo-Controlled Crossover Study of the Pharmacokinetics and Pharmacodynamics of Naloxone, Naltrexone, and Nalmefene in Methadone-Sedated Working Dogs. [PDF]
ABSTRACT A randomized, blinded, placebo‐controlled crossover study was performed with eight professional working dogs to evaluate the pharmacokinetics and pharmacodynamics of three opioid reversal agents. Following sedation with 1 mg kg−1 methadone HCl IV, dogs were randomly assigned to receive naloxone, naltrexone, or nalmefene at 0.1 mg kg−1 IM, or ...
Mills T+8 more
europepmc +2 more sources
Flexor Reflex Decreases during Sympathetic Stimulation in Chronic Human Spinal Cord Injury [PDF]
A better understanding of autonomic influence on motor reflex pathways in spinal cord injury is important to the clinical management of autonomic dysreflexia and spasticity in spinal cord injured patients.
Garrison, Mark Kevin, Schmit, Brian D.
core +2 more sources
Drug‐facilitated crime: A review of findings between 2019 and 2023
Abstract Drug‐facilitated crime (DFC) is a criminal act (e.g., assault, robbery, or sexual assault) in which the perpetrator uses drugs to impair the victim's ability to resist, remember, or recognize the crime being committed. Ethanol is commonly implicated in DFC casework, but limited data are published on other substances currently implicated in ...
Meaghan R. Hessler+2 more
wiley +1 more source