Results 1 to 10 of about 23,788 (138)

Suicide in Narcotic Drugs Dependents [PDF]

open access: yesAddiction and Health, 2012
Background: The problem of addiction is one of the four global crises. These patients are more vulnerable to mental disorders. This study aimed to examine the risk of suicide in drug dependent patients.
Alireza Ghaffari Nejad   +3 more
doaj   +1 more source

Application of electronic prescriptions for narcotic drugs in quality control [PDF]

open access: yesJichu yixue yu linchuang, 2022
Objective To investigate the significance of electronic prescriptions on the management of narcotic drugs, so as to constantly optimize the management of narcotic drugs.
BAI Bing, YANG Gen-zhi, ZHANG Yue-lun, TIAN Yuan, SHEN Le, HUANG Yu-guang
doaj   +1 more source

The Role of Epigenetic Modifications in Neurotoxicity Induced by Neonatal General Anesthesia

open access: yesFrontiers in Molecular Neuroscience, 2022
It has been widely demonstrated by numerous preclinical studies and clinical trials that the neonates receiving repeated or long-time general anesthesia (GA) could develop prolonged cognitive dysfunction.
Lin-Hui Ma   +8 more
doaj   +1 more source

Comparative study on main compounds and hypoglycemic effects of dispensing granules of Coptidis Rhizoma and Scutellaria–Coptis herb couple with traditional decoction

open access: yesChinese Medicine, 2023
Background The clinical applications of dispensing granules (DG) have increased dramatically. However, it is controversial whether the DG has the same quality and efficacy compared with traditional decoction (TD).
Huanhuan Yu   +7 more
doaj   +1 more source

Dissecting the novel abilities of aripiprazole: The generation of anti-colorectal cancer effects by targeting Gαq via HTR2B

open access: yesActa Pharmaceutica Sinica B, 2023
Colorectal cancer (CRC) is a type of malignant tumor that seriously threatens human health and life, and its treatment has always been a difficulty and hotspot in research.
Haowei Liu   +5 more
doaj   +1 more source

Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer’s disease models

open access: yesCell Death Discovery, 2021
Alzheimer’s disease (AD) is characterized by aberrant accumulation of extracellular β-amyloid (Aβ) peptides in the brain. Soluble Aβ oligomers are thought to be the most neurotoxic species and are correlated with cognitive dysfunction in early AD ...
Xiu Yang   +13 more
doaj   +1 more source

Two parallel medial prefrontal cortex-amygdala pathways mediate memory deficits via glutamatergic projection in surgery mice

open access: yesCell Reports, 2023
Summary: The neural circuit mechanisms underlying postoperative cognitive dysfunction (POCD) remain elusive. We hypothesized that projections from the medial prefrontal cortex (mPFC) to the amygdala are involved in POCD.
Xiao-Yu Sun   +7 more
doaj   +1 more source

A common neuronal ensemble in nucleus accumbens regulates pain-like behaviour and sleep

open access: yesNature Communications, 2023
A comorbidity of chronic pain is sleep disturbance. Here, we identify a dual-functional ensemble that regulates both pain-like behaviour induced by chronic constrictive injury or complete Freund’s adjuvant, and sleep wakefulness, in the nucleus accumbens
Haiyan Sun   +8 more
doaj   +1 more source

Transcranial Electrical Stimulation for Relief of Peripartum Mental Health Disorders in Women Undergoing Cesarean Section With Combined Spinal–Epidural Anesthesia: A Pilot Randomized Clinical Trial

open access: yesFrontiers in Psychiatry, 2022
ObjectiveThis study aimed to explore transcranial electrical stimulation (tES) to relieve peripartum anxiety and depressive symptoms in women undergoing cesarean section with combined spinal–epidural anesthesia.MethodsThis double-blind, randomized, sham ...
Qiu Zhao   +30 more
doaj   +1 more source

The Slack Channel Deletion Causes Mechanical Pain Hypersensitivity in Mice

open access: yesFrontiers in Molecular Neuroscience, 2022
The role of the Slack (also known as Slo2.2, KNa1.1, or KCNT1) channel in pain-sensing is still in debate on which kind of pain it regulates. In the present study, we found that the Slack–/– mice exhibited decreased mechanical pain threshold but normal ...
Ye Liu   +34 more
doaj   +1 more source

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