Fluorescent Probes Derived from the Polyene Class of Antifungal Drugs Reveal Distinct Localization Patterns and Resistance-Associated Vacuolar Sequestration in Candida Species. [PDF]
Angew Chem Int Ed EnglFluorescent probes derived from all three clinically used polyene antifungals (amphotericin B, nystatin, and natamycin) enabled direct visualization of distribution in yeast cells of various Candida species. While retaining the ergosterol‐dependent mode of action of their parent drugs, the probes revealed distinct, structure‐specific localization ...
Shbeta M +6 more
europepmc +3 more sources
Novel mechanism of hydrogen peroxide for promoting efficient natamycin synthesis in Streptomyces
Microbiology Spectrum, 2023 The mechanism of regulation of natamycin biosynthesis by Streptomyces in response to oxidative stress is unclear. Here, we first show cholesterol oxidase SgnE, which catalyzes the formation of H2O2 from sterols, triggered a series of redox-dependent ...
Gongli Zong +9 more
doaj +1 more source
Recognition of Membrane Sterols by Polyene Antifungals Amphotericin B and Natamycin, A 13C MAS NMR Study [PDF]
, 2016 The molecular action of polyene macrolides with antifungal activity, amphotericin B and natamycin, involves recognition of sterols in membranes. Physicochemical and functional studies have contributed details to understanding the interactions between ...
Bonev, BB +5 more
core +7 more sources
Natamycin-Loaded Ethyl Cellulose/PVP Films Developed by Microfluidic Spinning for Active Packaging
Foods, 2023 The preparation of active packaging loaded with antimicrobial, antioxidant, and other functional agents has become a hot topic for food preservation in recent years.
Xiangzheng Yang +6 more
doaj +1 more source
Natamycin in the treatment of fungal keratitis:a systematic review and Meta-analysis [PDF]
International Journal of Ophthalmology, 2015 AIM: To review published clinical studies examining the effect of natamycin in the treatment of fungal keratitis.METHODS:We selected the publications in CENTRAL, MEDLINE, EMBASE, CNKI, and CBM.
Sheng Qiu +7 more
doaj +1 more source
Antifungal Combination Eye Drops for Fungal Keratitis Treatment
Pharmaceutics, 2022 Fungal keratitis (FK) is a corneal mycotic infection that can lead to vision loss. Furthermore, the severity of FK is aggravated by the emergence of resistant fungal species.
Victoria Díaz-Tomé +10 more
doaj +1 more source
Indian Journal of Ophthalmology, 2022 Purpose: To study the antifungal susceptibility of common corneal pathogenic fungi to antifungal agents in the North Indian population. Methods: Prospective study of the antifungal sensitivity testing (natamycin, amphotericin B, voriconazole ...
Murugesan Vanathi +5 more
doaj +1 more source
Counselling for people with sight loss in the UK: The need for provision and the need for evidence [PDF]
, 2010 For adults of any age the diagnosis of a visual impairment can be traumatic, and timely referral to informal peer support and/or professional counselling may be both beneficial and appropriate.
Gosney, M.A., Nyman, S.R., Victor, C.R.
core +1 more source
Development of active and nanotechnology-based smart edible packaging systems: physical-chemical characterization [PDF]
, 2014 This work aims at characterising polysaccharide-based films without (GA) and with the incorporation of free natamycin (GA-NA) and natamycin-loaded in a smart delivery device consisting in poly(N-isopropylacrylamide) nanohydrogels (GA-PNIPA).
Cerqueira, M. A. +4 more
core +1 more source
Heliyon, 2019 The effectiveness of natamycin supported in corn starch-based films to control environmental molds (mainly Penicillium spp) activity that could colonize the surface of semi-hard cheese during ripening, was evaluated.
Lucía del Sol González-Forte +2 more
doaj +1 more source