Results 51 to 60 of about 1,947 (140)

Outer Membrane Vesicles as a Versatile Platform for Vaccine Development: Engineering Strategies, Applications and Challenges

Journal of Extracellular Vesicles, Volume 14, Issue 9, September 2025.
ABSTRACT Outer membrane vesicles (OMVs) are nanosized vesicles naturally secreted by Gram‐negative bacteria and represent a promising platform for vaccine development. OMVs possess inherent immunostimulatory properties due to the presence of pathogen‐associated molecular patterns (PAMPs), providing self‐adjuvanting capabilities and the ability to ...
Asja Garling, Frédéric Auvray, Mathieu Epardaud, Éric Oswald, Priscilla Branchu   +4 more
wiley   +1 more source

Intelligent peptide‐based nanomaterials for targeted antibacterial therapy: Design, properties and applications

Responsive Materials, Volume 3, Issue 3, August 2025.
This review comprehensively discusses intelligent peptide‐based nanomaterials from the design, mechanisms, properties, and applications, taking stimuli responsiveness as a starting point. Abstract Bacterial infections pose a major threat to human health as well as livestock production. Traditional antibiotics face significant limitations in the complex
Chenlong Zhou, Qi Tang, Shuaikang Yang, Guanghui Zhao, Tao Wang, Zhenduo Chen, Yucheng Zhang, Peng Tan, Xi Ma   +8 more
wiley   +1 more source

The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation [PDF]

, 2016
The widespread use of antibiotics in the past 80 years has saved millions of human lives, facilitated technological progress and killed incalculable numbers of microbes, both pathogenic and commensal.
Crook, Nathan, Dantas, Gautam, Langdon, Amy   +2 more
core   +2 more sources

Encapsulation of the Antistaphylococcal Endolysin LysRODI in pH-Sensitive Liposomes [PDF]

, 2020
© 2020 by the authors.Phage lysins are promising new therapeutics against multidrug-resistant bacteria. These so-called enzybiotics offer, amongst their most notable advantages, high target specificity and low resistance development.
Fernández, Lucía, García Suárez, María Pilar, Gutiérrez, Diana, Portilla Vázquez, Silvia, Rodríguez González, Ana   +4 more
core   +1 more source

Opinion of the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) on defining pathogenic strains of Shiga toxin‐producing Escherichia coli

Food Risk Assess Europe, Volume 3, Issue 3, July 2025.
ABSTRACT Shiga toxin‐producing Escherichia coli (STEC) are pathogenic E. coli strains that have been associated with a wide range of human clinical illness ranging from mild diarrhoea to bloody diarrhoea (BD) and haemolytic uremic syndrome (HUS). In its opinion of 18 May 2017, the French Agency for Food, Environmental and Occupational Health and Safety
Philippe Fravalo, Frédéric Auvray, Mickaël Boni, Frédéric Borges, Gilles Bornert, Frédéric Carlin, Catherine Chubilleau, Monika Coton, Georges Daube, Noémie Desriac, Florence Dubois‐Brissonnet, Michel Federighi, Michel Gautier, Michèle Gourmelon, Sandrine Guillou, Stéphane Guyot, Didier Hilaire, Nathalie Jourdan‐da Silva, Claire Le Henaff‐Le Marrec, Sandra Martin‐Latil, Jeanne‐Marie Membré, Eric Oswald, Nadia Oulahal, Pascal Piveteau, Sabine Schorr‐Galindo, Régine Talon, Isabelle Villena, Aurélie Cointe, Mickael Desvaux, Gabrielle Jones, Patricia Mariani‐Kurdjian, Frédérique Audiat‐Perrin, Laurent Guillier, Pauline Kooh   +33 more
wiley   +1 more source

A holin and an endopeptidase are essential for chitinolytic protein secretion in Serratia marcescens [PDF]

, 2014
Pathogenic bacteria adapt to their environment and manipulate the biochemistry of hosts by secretion of effector molecules. Serratia marcescens is an opportunistic pathogen associated with healthcare-acquired infections and is a prolific secretor of ...
Berkmen, Brurberg, Brurberg, Cox, de Lorenzo, Economou, English, Flyg, Folders, Francetic, Frank Sargent, Frederiksen, Fukushima, Goemans, Govind, Govind Chandra, Grant Buchanan, Gründling, Guzman, Hejazi, Hines, Hodak, Iguchi, Jack, Jaeger J. Hamilton, Javelle, Kaniga, Koraimann, Korotkov, Krehenbrink, Lee, Mahlen, Manman Guo, Manza, Marlow, Marília de Assis Alcoforado Costa, Matthias Trost, Nicola R. Stanley-Wall, Olling, Palmer, Papanikolau, Reddy, Richard A. Owen, Ritorto, Sarah J. Coulthurst, Scheurwater, Shcherbo, Strych, Summer, Suzuki, Suzuki, Tracy Palmer, Tran, Trost, Vaaje-Kolstad, Vaaje-Kolstad, Vaaje-Kolstad, Victoria L. Marlow, White, Wiśniewski   +59 more
core   +3 more sources

Exploiting phage receptor binding proteins to enable endolysins to kill Gram-negative bacteria [PDF]

, 2020
Bacteriophage-encoded endolysins degrading the bacterial peptidoglycan are promising antibacterials for combating antibiotic-resistant bacteria. However, endolysins have limited use against Gram-negative bacteria, since the outer membrane prevents access
Antenucci, Fabio, Bortolaia, Valeria, Briers, Yves, Brøndsted, Lone, Grimon, Dennis, Sørensen, Martine C.Holst, Vitt, Amira Ruslanovna, Zampara, Athina   +7 more
core   +2 more sources

Engineered Tissue Models to Decode Host–Microbiota Interactions

Advanced Science, Volume 12, Issue 23, June 20, 2025.
Host–Microbiota interactions in the human body. Created in BioRender. Ghezzi, C. (2025) https://BioRender.com/ihivskg. Abstract A mutualistic co‐evolution exists between the host and its associated microbiota in the human body. Bacteria establish ecological niches in various tissues of the body, locally influencing their physiology and functions, but ...
Miryam Adelfio, Grace E. Callen, Xuesong He, Bruce J. Paster, Hatice Hasturk, Chiara E. Ghezzi   +5 more
wiley   +1 more source

Structure and function of the Ts2631 endolysin of Thermus scotoductus phage vB_Tsc2631 with unique N-terminal extension used for peptidoglycan binding [PDF]

, 2019
To escape from hosts after completing their life cycle, bacteriophages often use endolysins, which degrade bacterial peptidoglycan. While mesophilic phages have been extensively studied, their thermophilic counterparts are not well characterized.
A Razvi, A Stefanska, A Stefanska, AA Morgan, AJ Baldwin, AS Panja, B Webb, C Carrasco-López, D Chakravorty, DA Dougherty, DC Nelson, E Krissinel, F Pucci, H Yoshida, J Agier, J Royet, K Dumorné, L Sawle, LP Kozlowski, M Plotka, M Plotka, MM Bradford, MS Kim, MY Shen, P Emsley, P Leone, P Schuck, P Tommaso Di, PD Adams, R Guan, R Lavigne, R Young, S Cho, S Kumar, S Sokalingam, SO Meroueh, SP Pack, T Kaczorowski, T Michel, T Sandalova, W Chen, X Cheng, Y Briers   +42 more
core   +2 more sources

Probiotic‐Based Approaches for Sustainable Control of Infectious Risk in Mass Transport: Current Data and Future Perspectives

Microbial Biotechnology, Volume 18, Issue 6, June 2025.
High‐traffic areas, such as mass transportation environments, can have a significant impact on infection transmission, and chemical disinfection may favour the selection of drug‐resistant microbes. Probiotic‐based approaches have the potential to be a novel and ecologically sustainable option for controlling bioburden and preventing infections ...
Irene Soffritti, Maria D'Accolti, Francesca Bini, Eleonora Mazziga, Antonella Volta, Matteo Bisi, Sante Mazzacane, Elisabetta Caselli   +7 more
wiley   +1 more source