Results 21 to 30 of about 18,013 (253)

2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins

Frontiers in Plant Science, 2014
Coumarins are natural plant products that have been the subject of extensive phytochemical and pharmacological research studies in the past few decades.
Bun-Ichi eShimizu
doaj   +1 more source

Applications of Natural Coumarins in Bone and Joint Diseases: Pharmacological Mechanisms and Advances in Clinical Research

Frontiers in Bioscience-Landmark
This review examines the applications of natural coumarins in the context of bone and joint disorders. It provides comprehensive coverage of their fundamental pharmacology, the epidemiology and pathological mechanisms of osteoarticular diseases, as well ...
Jianhui Ma, Wenjiao Wang, Xudong Zhang, Lu Wang, Zhengqi Liu, Cong Huang   +5 more
doaj   +1 more source

Chalepin and Chalepensin: Occurrence, Biosynthesis and Therapeutic Potential

Molecules, 2021
Dihydrofuranocoumarin, chalepin (1) and furanocoumarin, chalepensin (2) are 3-prenylated bioactive coumarins, first isolated from the well-known medicinal plant Ruta chalepensis L.
Lutfun Nahar, Shaymaa Al-Majmaie, Afaf Al-Groshi, Azhar Rasul, Satyajit D. Sarker   +4 more
doaj   +1 more source

Polyphenol‐Inspired Materials for Agricultural Applications

Advanced Materials, EarlyView.
This review outlines the use of polyphenol‐inspired materials for sustainable agriculture, highlighting their molecular design, interfacial assembly, structure–property relationships, and prospects toward precision agriculture, climate resilience, ecosystem protection, and circular bioeconomy strategies.
Haofu Liu, Omid Mazaheri, Zhixing Lin, Tianzheng Wang, Jingqu Chen, Yuang Gu, Xia Liang, Deli Chen, Frank Caruso   +8 more
wiley   +1 more source

S‐Nitrosothiols as Thiol‐Protecting Groups for Controlled Thiol‐Maleimide Crosslinking of Homogeneous Soft Hydrogels

Advanced Materials, EarlyView.
Rapid thiol‐maleimide addition frequently outpaces mixing, resulting in heterogeneous hydrogels. S‐nitrosothiols act as thiol‐protecting groups, allowing uniform mixing with maleimide‐functionalized polymers before gelation. Sodium thiosulfate or sodium ascorbate then regenerates thiols on demand, triggering controlled thiol‐maleimide crosslinking ...
Julian A. Serna, Michelle J. Iwohn, Maximilian Seifermann, Stefan Heißler, Maike Schliephake, Franziska Dopp, Claudia Muhle‐Goll, Pavel A. Levkin   +7 more
wiley   +1 more source

Coumarin as an Elite Scaffold in Anti-Breast Cancer Drug Development: Design Strategies, Mechanistic Insights, and Structure–Activity Relationships

Biomedicines
Breast cancer is the most common cancer among women. Currently, it poses a significant threat to the healthcare system due to the emerging resistance and toxicity of available drug candidates in clinical practice, thus generating an urgent need for the ...
Atamjit Singh, Karanvir Singh, Kamaljit Kaur, Amandeep Singh, Aman Sharma, Kirandeep Kaur, Jaskirat Kaur, Gurleen Kaur, Uttam Kaur, Harsimran Kaur, Prabhsimran Singh, Preet Mohinder Singh Bedi   +11 more
doaj   +1 more source

The Grapefruit Effect: Interaction between Cytochrome P450 and Coumarin Food Components, Bergamottin, Fraxidin and Osthole. X-ray Crystal Structure and DFT Studies

Molecules, 2020
Coumarins are plant-derived secondary metabolites. The crystal structure of three coumarins—bergamottin, osthole and fraxidin—are described and we analyze intermolecular interactions and their role in crystal formation.
Miriam Rossi, Sandjida Aktar, Marissa Davis, Emily Hefter Feuss, Samara Roman-Holba, Kelly Wen, Christopher Gahn, Francesco Caruso   +7 more
doaj   +1 more source

Smart Electrospun Nanofibers for Controlled Oil‐Water Separation

Advanced Materials Interfaces, EarlyView.
Stimuli‐responsive electrospun nanofibers are reviewed as advanced platforms for controlled oil/water separation. The effects of surface wettability, porous structure, and external stimuli, including pH, temperature, gas, and light, on separation performance are discussed.
Aynaz Sedaghatnia, Milad Babazadeh‐Mamaqani, Hossein Roghani‐Mamaqani, Donya Razzaghi, Amin Babaie, Reza Lotfi‐Mayan, Mostafa Rezaei   +6 more
wiley   +1 more source

The Study of Hypoglycemic Activity of 7-Terpenylcoumarins

Molecules, 2022
Natural and synthetic coumarins are often considered privileged scaffolds for obtaining pharmacological agents with hypoglycemic activity. Chemical modification of coumarins often leads to antidiabetic agents with greater efficacy.
Sergey Kuranov, Mariya Marenina, Dmitriy Ivankin, Mikhail Blokhin, Sergey Borisov, Tatyana Khomenko, Olga Luzina, Mikhail Khvostov, Konstantin Volcho, Tatyana Tolstikova, Nariman Salakhutdinov   +10 more
doaj   +1 more source

Pd‐Catalyzed Asymmetric Dearomative Heck/Tsuji‐Trost Difunctionalization of Naphthalenes

Advanced Science, EarlyView.
We have developed a palladium‐catalyzed asymmetric dearomative Heck/Tsuji‐Trost 1,4‐difunctionalization reaction of naphthalenes, affording 4‐aminospirocyclohexene oxindole products bearing two remote chiral centers. Through the effect of the newly designed chiral sulfinamide phosphine ligand with large steric hindrance, side reactions are inhibited ...
Long‐Ling Ma, Bing Xu, Junliang Zhang, Zhan‐Ming Zhang   +3 more
wiley   +1 more source