Results 91 to 100 of about 247,672 (311)

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao   +6 more
wiley   +1 more source

Detection of monoclonal T populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells

open access: yesHaematologica, 2014
The etiology of chronic large granular lymphocyte proliferations is largely unknown. Although these disorders are characterized by the expansion of different cell types (T and natural killer) with specific genetic features and abnormalities, several ...
Cristina Gattazzo   +14 more
doaj   +1 more source

Development of antibody technology to identify natural killer cell surface antigens in Xenopus Laevis [PDF]

open access: yes, 1999
Natural killer (NK)-like lymphocytes have recently been identified in thymectomised (Tx) Xenopus which are capable of spontaneous cytotoxicity towards the MHC- deficient, allogeneic thymus tumour cell line B(_3)B(_7).
Minter, Ralph
core  

Killer cell immunoglobulin-like receptors and their ligands : assessment of potential diagnostic and immunotherapeutic value [PDF]

open access: yes, 2014
Human natural killer (NK) cells constitute an important arm of the innate immune system, which participates in protection against viral infections and elimination of malignant diseases.
Czaja, Karol Gustaw
core   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird   +9 more
wiley   +1 more source

INJECTING DRUG USE AS A FACTOR CONTRIBUTES TO HIV-INFECTION

open access: yesМедицинский вестник Юга России, 2015
Purpose: to determine the nature of the impact of injecting drug use on cellular immunity and assessment of the importance of drug use as a factor contributing to HIV infection and aff ect the course of disease in HIV- positive patients.Materials and ...
Е. P. Stanko   +4 more
doaj   +1 more source

Marked Long‐Term Improvement in Lung Function in Melanoma Differentiation–Associated Protein 5 Antibody–Positive Dermatomyositis Patients: Experience of a Single‐Center Longitudinal Cohort in North America

open access: yesArthritis Care &Research, EarlyView.
Objective The objective of this study was to describe the longitudinal disease course and pulmonary outcomes of North American patients with melanoma differentiation–associated protein 5 (MDA5) antibody–associated dermatomyositis (DM). Methods Thirty patients with MDA5 antibody–associated DM were identified in a single‐center longitudinal cohort of 352
Jenice X. Cheah   +8 more
wiley   +1 more source

Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury [PDF]

open access: yesInternational Journal of Molecular Sciences, 2019
Mouse natural killer T (NKT) cells and natural killer (NK) cells are innate immune cells that are highly abundant in the liver. In addition to their already-known antitumor and antimicrobial functions, their pathophysiological roles in the kidney have recently become evident.
Takahiro Uchida   +5 more
openaire   +2 more sources

Natural Bone‐Derived Ceramic Scaffolds Functionalized with Chitosan‐Gold, Chitosan‐Magnesium, and Chitosan‐Zinc for Enhanced Antibacterial Activity

open access: yesAdvanced Engineering Materials, EarlyView.
This study reports the development of antibacterial ceramic scaffolds derived from natural bovine bone. The bones were processed through sequential boiling and hydrogen peroxide treatment to remove organic matter, producing porous, mineral‐rich scaffolds.
Mohamad Hassan Taherian   +6 more
wiley   +1 more source

Natural killer cells in multiple sclerosis: foe or friends?

open access: yesFrontiers in Cellular Neuroscience
Multiple sclerosis (MS) is an immune-mediated disorder involving the central nervous system (CNS), in which demyelination is caused. The initiation and progression of MS is thought to depend largely on CD4+ T lymphocytes, yet new data has emphasized the ...
Fatemeh Aghaee   +5 more
doaj   +1 more source

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