Results 11 to 20 of about 323,886 (359)

T cell regulation of natural killer cells [PDF]

Journal of Experimental Medicine, 2013
In light of their role in the immune response against tumors and viruses, natural killer (NK) cells represent a promising target for immunotherapy. Before this target is reached, the various mechanisms that control NK cell activity must first be identified and understood.
Yann M. Kerdiles, Sophie Ugolini, Éric Vivier   +2 more
openalex   +3 more sources

Targeting natural killer cells and natural killer T cells in cancer [PDF]

Nature Reviews Immunology, 2012
Natural killer (NK) cells and natural killer T (NKT) cells are subsets of lymphocytes that share some phenotypical and functional similarities. Both cell types can rapidly respond to the presence of tumour cells and participate in antitumour immune responses. This has prompted interest in the development of innovative cancer therapies that are based on
Vivier, Eric, Ugolini, Sophie, Blaise, Didier, Chabannon, Christian, Brossay, Laurent   +4 more
openaire   +3 more sources

Natural killer cells and natural killer T cells in Lyme arthritis [PDF]

Arthritis Research & Therapy, 2013
Abstract Introduction Natural killer (NK) and natural killer T (NKT) cells provide a first line of defense against infection. However, these cells have not yet been examined in patients with Lyme arthritis, a late disease manifestation. Lyme arthritis usually resolves with antibiotic treatment.
Katchar, Kia, Drouin, Elise E, Steere, Allen   +2 more
openaire   +3 more sources

Combined immune checkpoint blockade and radiotherapy induces durable remission in relapsed natural killer/T-cell lymphoma: a case report and review of the literature

Journal of Medical Case Reports, 2021
Background Extranodal natural killer/T-cell lymphoma is a rare, aggressive non-Hodgkin lymphoma that is treated upfront mostly with L-asparaginase containing regimens. Relapsed extranodal natural killer/T-cell lymphoma is associated with a poor prognosis,
Elizabeth McGehee, Hetalkumari Patel, Caroline Pearson, Keri Clements, Jesse Manuel Jaso, Weina Chen, Alexandra Callan, Neil Desai, Praveen Ramakrishnan Geethakumari   +8 more
doaj   +1 more source

Natural Killer T Cell Based Immunotherapy [PDF]

Journal of Vaccines & Vaccination, 2012
Natural killer T (NKT) cells play an important immunoregulatory role and are thought to bridge the innate and adaptive immune responses. Following activation through cognate interactions with lipid antigen presented in the context of CD1d molecules, NKT cells rapidly produce a plethora of cytokines and can also mediate cytotoxicity. Due to their potent
Priyanka B, Subrahmanyam, Wenji, Sun, James E, East, Junxin, Li, Tonya J, Webb   +4 more
openaire   +2 more sources

Impact of NKG2D Signaling on Natural Killer and T‐Cell Function in Cerebral Ischemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Typically defined as a thromboinflammatory disease, ischemic stroke features early and delayed inflammatory responses, which determine the extent of ischemia‐related brain damage.
Christina David, Tobias Ruck, Leoni Rolfes, Stine Mencl, Peter Kraft, Michael K. Schuhmann, Christina B. Schroeter, Robin Jansen, Friederike Langhauser, Anne K. Mausberg, Anke C. Fender, Sven G. Meuth, Christoph Kleinschnitz   +12 more
doaj   +1 more source

Natural killer T cells: Know thyself [PDF]

Proceedings of the National Academy of Sciences, 2007
There are two main reasons why natural killer T (NKT) cells fascinate immunologists. First, they exhibit a unique melange of properties found in innate immune cells as well as the properties of conventional T cells, part of adaptive immunity (1–4). Second, NKT cells exercise a determining influence on a variety of immune responses in mice, ranging from
Mitchell, Kronenberg, Laurent, Gapin
openaire   +2 more sources

Functional invariant natural killer T-cell and CD1d axis in chronic lymphocytic leukemia: implications for immunotherapy

Haematologica, 2013
Invariant natural killer T cells recognize glycolipid antigens such as α-galactosylceramide presented by CD1d. In preclinical models of B-cell malignancies, α-galactosylceramide is an adjuvant to tumor vaccination, enhancing tumor-specific T-cell ...
Robert Weinkove, Collin R. Brooks, John M. Carter, Ian F. Hermans, Franca Ronchese   +4 more
doaj   +1 more source

Detection of monoclonal T populations in patients with KIR-restricted chronic lymphoproliferative disorder of NK cells

Haematologica, 2014
The etiology of chronic large granular lymphocyte proliferations is largely unknown. Although these disorders are characterized by the expansion of different cell types (T and natural killer) with specific genetic features and abnormalities, several ...
Cristina Gattazzo, Antonella Teramo, Francesca Passeri, Elena De March, Samuela Carraro, Valentina Trimarco, Federica Frezzato, Tamara Berno, Gregorio Barilà, Veronica Martini, Francesco Piazza, Livio Trentin, Monica Facco, Gianpietro Semenzato, Renato Zambello   +14 more
doaj   +1 more source

Natural Killer T Cell Diversity and Immunotherapy. [PDF]

Cancers (Basel), 2023
Invariant natural killer T cells (iNKTs), a type of unconventional T cells, share features with NK cells and have an invariant T cell receptor (TCR), which recognizes lipid antigens loaded on CD1d molecules, a major histocompatibility complex class I (MHC-I)-like protein.
Tognarelli EI, Gutiérrez-Vera C, Palacios PA, Pasten-Ferrada IA, Aguirre-Muñoz F, Cornejo DA, González PA, Carreño LJ.   +7 more
europepmc   +3 more sources