Results 31 to 40 of about 50 (46)
Some of the next articles are maybe not open access.
Natural Killer Cells and the Syndrome of Chronic Natural Killer Cell Lymphocytosis
Leukemia & Lymphoma, 2001Natural killer (NK) cells provide anti-infectious, anti-neoplastic, and immunomodulatory function effected by both cytokine production and direct cellular cytotoxicity that is not major histocompatibility complex-restricted. NK cells lack truly specific cell surface determinants as well as antigen-specific receptors.
Paul J. Leibson +2 more
openaire +3 more sources
Trafficking of Natural Killer Cells
Current Molecular Medicine, 2004Natural killer (NK) cells comprise a set of lymphocytes that is capable of mediating innate immune responses to viral infections, malignancies, and allogeneic bone marrow grafts. This review summarizes what is known about the mechanisms NK cells use to arrive at their sites of action.
K Ley, M A Morris
openaire +2 more sources
Current Opinion in Immunology, 1995
In killing of cellular targets, natural killer cells employ receptors that activate them and receptors specific for MHC class I that inhibit their activation. Progress in understanding the inhibitory receptors has been rapid, and indications are that they fall into two distinct structural types that appear to utilize the same inhibitory signaling ...
openaire +3 more sources
In killing of cellular targets, natural killer cells employ receptors that activate them and receptors specific for MHC class I that inhibit their activation. Progress in understanding the inhibitory receptors has been rapid, and indications are that they fall into two distinct structural types that appear to utilize the same inhibitory signaling ...
openaire +3 more sources
The enigma of the natural killer cell
Nature, 1995Natural killer (NK) cells are controlled by receptors specific for polymorphic determinants of class I molecules of the major histocompatibility complex (MHC). The contrasting properties of NK and cytotoxic T cell (CTL) class I receptors provide complementarity in the cytolytic lymphocyte response to viruses, tumours and transplants.
Peter Parham, Jenny E. Gumperz
openaire +3 more sources
Natural killer cell metabolism
Molecular Immunology, 2019Natural killer (NK) cells are a critical component in the innate immune response against disease. NK cell function is tightly regulated by specific cytokine and activation/inhibitory receptor signalling, leading to diverse effector responses. Like all living cells, energy metabolism is a fundamental requirement for NK cell activation and survival ...
Kobayashi, Takumi +1 more
openaire +4 more sources
What is natural in natural killer cells?
Immunology Letters, 2006Denomination is a not a trivial issue in human activities in general, and in science in particular. Natural killer (NK) cells have been originally characterized as cytolytic effector lymphocytes present in mouse spleen and human peripheral blood. The "NK" name was originally coined after the NK cell's ability to kill targets cells without requirement ...
openaire +3 more sources
Natural Killer T Cells and Asthma
New England Journal of Medicine, 2006Invariant natural killer T cells, originally characterized in mice and more recently defined in humans, are a unique, conserved T-cell sublineage possessing a rearrangement of the T-cell antigen receptor (Vα14Jα18 in mice and Vα24Jα18 in humans). Human natural killer T cells also have an invariant β chain (Vβ11). Vα24Vβ11 binds to glycolipids presented
openaire +3 more sources
Natural killer cells and pregnancy
Nature Reviews Immunology, 2002The fetus is considered to be an allograft that, paradoxically, survives pregnancy despite the laws of classical transplantation immunology. There is no direct contact of the mother with the embryo, only with the extraembryonic placenta as it implants in the uterus.
openaire +3 more sources
2016
In recent years, roles of the immune system in immune surveillance of cancer have been explored. And natural killer (NK) cells are considered to be critical players in anticancer immunity. However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cells.
openaire +3 more sources
In recent years, roles of the immune system in immune surveillance of cancer have been explored. And natural killer (NK) cells are considered to be critical players in anticancer immunity. However, cancers are able to develop mechanisms to escape NK cell attack or to induce defective NK cells.
openaire +3 more sources
Natural Killer Cells for Osteosarcoma
2014Natural killer (NK) cells are lymphocytes of the innate immune system that have the ability to recognize malignant cells through detection of a variety of cell-surface indicators of stress and danger. Once activated through such recognition, NK cells release cytokines and induce target cell lysis through a variety of mechanisms.
Nidale Tarek, Dean A. Lee
openaire +3 more sources