Results 31 to 40 of about 371,435 (345)

Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Lung Infections

Frontiers in Immunology, 2018
The immune system has been traditionally divided into two arms called innate and adaptive immunity. Typically, innate immunity refers to rapid defense mechanisms that set in motion within minutes to hours following an insult.
François Trottein, François Trottein, François Trottein, François Trottein, François Trottein, Christophe Paget, Christophe Paget   +6 more
doaj   +1 more source

Adipose invariant natural killer T cells [PDF]

Immunology, 2014
SummaryAdipose tissue is a dynamic organ that makes up a substantial proportion of the body; in severe obesity it can account for 50% of body mass. Details of the unique immune system resident in human and murine adipose tissue are only recently emerging, and so it has remained a largely unexplored and unappreciated immune site until now.
openaire   +2 more sources

Tumor-derived lactate and myeloid-derived suppressor cells: Linking metabolism to cancer immunology [PDF]

, 2014
Many malignant cells produce increased amounts of lactate, which promotes the development of myeloid-derived suppressor cells (MDSCs). MDSCs, lactate, and a low pH in the tumor microenvironment inhibit the function of natural killer (NK) cells and T ...
Husain, Zaheed, Seth, Pankaj, Sukhatme, Vikas P   +2 more
core   +1 more source

Ex vivo-expanded highly purified natural killer cells in combination with temozolomide induce antitumor effects in human glioblastoma cells in vitro.

PLoS ONE, 2019
Glioblastoma is the leading malignant glioma with a poor prognosis. This study aimed to investigate the antitumor effects of natural killer cells in combination with temozolomide as the standard chemotherapeutic agent for glioblastoma.
Yoshitaka Tanaka, Tsutomu Nakazawa, Mitsutoshi Nakamura, Fumihiko Nishimura, Ryosuke Matsuda, Koji Omoto, Yoichi Shida, Toshiharu Murakami, Ichiro Nakagawa, Yasushi Motoyama, Hiromichi Morita, Takahiro Tsujimura, Hiroyuki Nakase   +12 more
doaj   +1 more source

Epstein–Barr Virus-Specific Immune Control by Innate Lymphocytes

Frontiers in Immunology, 2017
Epstein–Barr virus (EBV) is a potent B cell transforming pathogen in humans. In most persistently EBV-infected individuals, potent cytotoxic lymphocyte responses prevent EBV-associated pathologies.
Christian Münz
doaj   +1 more source

Stimulation of Natural Killer T Cells by Glycolipids

Molecules, 2013
Natural killer T (NKT) cells are a subset of T cells that recognize glycolipid antigens presented by the CD1d protein. The initial discovery of immunostimulatory glycolipids from a marine sponge and the T cells that respond to the compounds has led to ...
Brian L. Anderson, Luc Teyton, Albert Bendelac, Paul B. Savage   +3 more
doaj   +1 more source

New cell sources for CAR-based immunotherapy

Biomarker Research, 2023
Chimeric antigen receptor (CAR) T cell therapy, in which a patient’s own T lymphocytes are engineered to recognize and kill cancer cells, has achieved striking success in some hematological malignancies in preclinical and clinical trials, resulting in ...
Marzieh Mazinani, Fatemeh Rahbarizadeh
doaj   +1 more source

Immune mediated autologous cytotoxicity against hematopoietic precursor cells in patients with myelodysplastic syndrome

Haematologica, 2009
Background An activated immune system has been observed in patients with myelodysplastic syndrome but its exact contribution to disease development and control is not fully clarified.
Martine E.D. Chamuleau, Theresia M. Westers, Linda van Dreunen, Judith Groenland, Adri Zevenbergen, Corien M. Eeltink, Gert J. Ossenkoppele, Arjan A. van de Loosdrecht   +7 more
doaj   +1 more source

Impact of NKG2D Signaling on Natural Killer and T‐Cell Function in Cerebral Ischemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Typically defined as a thromboinflammatory disease, ischemic stroke features early and delayed inflammatory responses, which determine the extent of ischemia‐related brain damage.
Christina David, Tobias Ruck, Leoni Rolfes, Stine Mencl, Peter Kraft, Michael K. Schuhmann, Christina B. Schroeter, Robin Jansen, Friederike Langhauser, Anne K. Mausberg, Anke C. Fender, Sven G. Meuth, Christoph Kleinschnitz   +12 more
doaj   +1 more source

Lineage Differentiation Program of Invariant Natural Killer T Cells [PDF]

, 2017
Invariant natural killer T (iNKT) cells are innate T cells restricted by CD1d molecules. They are positively selected in the thymic cortex and migrate to the medullary area, in which they differentiate into 3 different lineages.
Dong-il Kwon, You Jeong Lee
core   +1 more source