Results 41 to 50 of about 371,435 (345)

Highly activated and expanded natural killer cells for multiple myeloma immunotherapy

Haematologica, 2012
Background Patients with gene expression profiling-defined high-risk myeloma in relapse have poor outcomes with current therapies. We tested whether natural killer cells expanded by co-culture with K562 cells transfected with 41BBL and membrane-bound ...
Tarun K. Garg, Susann M. Szmania, Junaid A. Khan, Antje Hoering, Paul A. Malbrough, Amberly Moreno-Bost, Amy D. Greenway, Joshuah D. Lingo, Xin Li, Shmuel Yaccoby, Larry J. Suva, Brian Storrie, Guido Tricot, Dario Campana, John D. Shaughnessy, Bijay P. Nair, William T. Bellamy, Joshua Epstein, Bart Barlogie, Frits van Rhee   +19 more
doaj   +1 more source

Topographical Distribution and Spatial Interactions of Innate and Semi-Innate Immune Cells in Pancreatic and Other Periampullary Adenocarcinoma

Frontiers in Immunology, 2020
BackgroundThe clinical management of pancreatic and other periampullary neoplasms remains challenging. In contrast to other cancer types, immunotherapies are largely ineffective, and the reason for the deprived immune response and the immune inhibiting ...
Sebastian Lundgren, Patrick Micke, Jacob Elebro, Margareta Heby, Ina Hrynchyk, Björn Nodin, Karin Leandersson, Artur Mezheyeuski, Karin Jirström   +8 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The role of NK and NKT cells in the pathogenesis and improvement of multiple sclerosis following disease‐modifying therapies

Health Science Reports, 2022
Background Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS) that T cells become autoreactive by recognizing CNS antigens. Both innate and adaptive immune systems are involved in the pathogenesis of MS.
Alireza Ahmadi, Zahra Fallah Vastani, Mahdi Abounoori, Mahdieh Azizi, Alireza Labani‐Motlagh, Sajad Mami, Sanaz Mami   +6 more
doaj   +1 more source

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70 [PDF]

, 2018
Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions develop in the mouse thymus, but the factors driving their differentiation remain unclear.
A Hutloff, AK Stanic, B San Luis, BB Au-Yeung, BB Au-Yeung, CQ Chu, D Davidson, DG Pellicci, DG Pellicci, DG Wei, DI Godfrey, EJ Wherry, F Scheuplein, F Scheuplein, FW McNab, G Anderson, G Fu, G Kollias, G Seumois, H Georgiev, H Watarai, HS Azzam, I Engel, I Engel, J Henao-Mejia, J Novak, J Zikherman, JL Matsuda, JL Matsuda, JM Mason, K Benlagha, K Hirota, K Oleinika, K Yamamoto, L Brossay, L Linsen, LH Mason, LM D'Cruz, M Cruz Tleugabulova, M Gaya, M Guma, M Hashimoto, M Kronenberg, M Zhu, MA Weinreich, MB Drennan, MC Leite-De-Moraes, MC Leite-De-Moraes, MI Zimmer, MP Seiler, N Bottini, N Sakaguchi, NA Nagarajan, R Genolet, RJ Martinez, S Akbulut, S Jung, S Picelli, S Sidobre, SE Levin, TN Newman, V Cerundolo, V Sivakumar, WY Lee, X Li, YJ Lee, YL Chiu   +66 more
core   +4 more sources

Roles of Natural Killer T Cells and Natural Killer Cells in Kidney Injury [PDF]

International Journal of Molecular Sciences, 2019
Mouse natural killer T (NKT) cells and natural killer (NK) cells are innate immune cells that are highly abundant in the liver. In addition to their already-known antitumor and antimicrobial functions, their pathophysiological roles in the kidney have recently become evident.
Takahiro Uchida, Seigo Ito, Hiroo Kumagai, Takashi Oda, Hiroyuki Nakashima, Shuhji Seki   +5 more
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Phosphotyrosines in the killer cell inhibitory receptor motif of NKB1 are required for negative signaling and for association with protein tyrosine phosphatase 1C. [PDF]

, 1996
NKB1 is one member of a growing family of killer cell inhibitory receptors (KIR). It is expressed on natural killer (NK) cells and T cells, and has been shown to inhibit cytolytic functions of these cells upon interacting with its ligand, HLA-B (Bw4). We
Fry, AM, Lanier, LL, Weiss, A
core   +1 more source

Synthesis of C-5" and C-6"-modified α-GalCer analogues as iNKT-cell agonists [PDF]

, 2015
Alpha-Galactosyl Ceramide (α-GalCer) is a prototypical synthetic ligand of invariant natural killer T (iNKT) cells. Upon presentation by the MHC class I-like molecule CD1d, this glycolipid stimulates iNKT cells to secrete a vast amount of both pro ...
ASPESLAGH, SANDRINE, Elewaut, Dirk, Guillaume, Joren, Pauwels, Nora, Van Calenbergh, Serge, Zajonc, Dirk   +5 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source