Results 51 to 60 of about 366,560 (304)

Natural killer and natural killer T cells in liver fibrosis

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2013
The liver lymphocyte population is enriched with natural killer (NK) cells, which play a key role in host defense against viral infection and tumor transformation. Recent evidence from animal models suggests that NK cells also play an important role in inhibiting liver fibrosis by selectively killing early or senescence activated hepatic stellate cells
Gao, Bin, Radaeva, Svetlana
openaire   +2 more sources

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

Activated iNKT cells enhance the anti-tumor effect of antigen specific CD8 T cells on mesothelin-expressing salivary gland cancer

BMC Cancer, 2018
Background Salivary gland cancers are not sensitive to conventional radiotherapy or chemotherapy regimens. Therefore, the development of a new treatment strategy is of critical importance for improving the prognosis.
Yuji Makita, Naoki Kunii, Daiju Sakurai, Fumie Ihara, Shinichiro Motohashi, Akane Suzuki, Toshinori Nakayama, Yoshitaka Okamoto   +7 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Natural killer-cell counts are associated with molecular relapse-free survival after imatinib discontinuation in chronic myeloid leukemia: the IMMUNOSTIM study

Haematologica, 2017
Despite persistence of leukemic stem cells, patients with chronic myeloid leukemia who achieve and maintain deep molecular responses may successfully stop the tyrosine kinase inhibitor imatinib.
Delphine Rea, Guylaine Henry, Zena Khaznadar, Gabriel Etienne, François Guilhot, Franck Nicolini, Joelle Guilhot, Philippe Rousselot, Françoise Huguet, Laurence Legros, Martine Gardembas, Viviane Dubruille, Agnès Guerci-Bresler, Aude Charbonnier, Frédéric Maloisel, Jean-Christophe Ianotto, Bruno Villemagne, François-Xavier Mahon, Hélène Moins-Teisserenc, Nicolas Dulphy, Antoine Toubert   +20 more
doaj   +1 more source

Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70 [PDF]

, 2018
Various subsets of invariant natural killer T (iNKT) cells with different cytokine productions develop in the mouse thymus, but the factors driving their differentiation remain unclear.
A Hutloff, AK Stanic, B San Luis, BB Au-Yeung, BB Au-Yeung, CQ Chu, D Davidson, DG Pellicci, DG Pellicci, DG Wei, DI Godfrey, EJ Wherry, F Scheuplein, F Scheuplein, FW McNab, G Anderson, G Fu, G Kollias, G Seumois, H Georgiev, H Watarai, HS Azzam, I Engel, I Engel, J Henao-Mejia, J Novak, J Zikherman, JL Matsuda, JL Matsuda, JM Mason, K Benlagha, K Hirota, K Oleinika, K Yamamoto, L Brossay, L Linsen, LH Mason, LM D'Cruz, M Cruz Tleugabulova, M Gaya, M Guma, M Hashimoto, M Kronenberg, M Zhu, MA Weinreich, MB Drennan, MC Leite-De-Moraes, MC Leite-De-Moraes, MI Zimmer, MP Seiler, N Bottini, N Sakaguchi, NA Nagarajan, R Genolet, RJ Martinez, S Akbulut, S Jung, S Picelli, S Sidobre, SE Levin, TN Newman, V Cerundolo, V Sivakumar, WY Lee, X Li, YJ Lee, YL Chiu   +66 more
core   +4 more sources

Natural Killer T Cell Diversity and Immunotherapy

Cancers, 2023
Invariant natural killer T cells (iNKTs), a type of unconventional T cells, share features with NK cells and have an invariant T cell receptor (TCR), which recognizes lipid antigens loaded on CD1d molecules, a major histocompatibility complex class I (MHC-I)-like protein.
Eduardo I. Tognarelli, Cristián Gutiérrez-Vera, Pablo A. Palacios, Ignacio A. Pasten-Ferrada, Fernanda Aguirre-Muñoz, Daniel A. Cornejo, Pablo A. González, Leandro J. Carreño   +7 more
openaire   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Antitumor Responses of Invariant Natural Killer T Cells

Journal of Immunology Research, 2015
Natural killer T (NKT) cells are innate-like lymphocytes that were first described in the late 1980s. Since their initial description, numerous studies have collectively shed light on their development and effector function.
Jennie B. Altman, Adriana D. Benavides, Rupali Das, Hamid Bassiri   +3 more
doaj   +1 more source

Antigen specificity of invariant natural killer T-cells

Biomedical Journal, 2015
Natural killer T-cells, with an invariant T-cell antigen receptor α-chain (iNKT cells), are unique and conserved subset of lymphocytes capable of altering the immune system through their rapid and potent cytokine responses.
Alysia M. Birkholz, Mitchell Kronenberg
doaj   +1 more source