Results 61 to 70 of about 230,395 (312)
Tumor recognition by natural killer cells in acute myeloid leukemia and after hematopoietic stem cell transplantation [PDF]
, 2005 Natural killer (NK) cell-mediated cytolytic activity against tumors requires the engagement of activating NK cell receptors by the tumor-associated ligands.
Nowbakht, Pegah
core +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Antitumor Responses of Invariant Natural Killer T Cells
Journal of Immunology Research, 2015 Natural killer T (NKT) cells are innate-like lymphocytes that were first described in the late 1980s. Since their initial description, numerous studies have collectively shed light on their development and effector function.
Jennie B. Altman +3 more
doaj +1 more source
Haematologica, 2017 Despite persistence of leukemic stem cells, patients with chronic myeloid leukemia who achieve and maintain deep molecular responses may successfully stop the tyrosine kinase inhibitor imatinib.
Delphine Rea +20 more
doaj +1 more source
Increased angiogenic factor secretion by decidual natural killer cells from pregnancies with high uterine artery resistance alters trophoblast function. [PDF]
, 2014 STUDY QUESTION Are the concentrations of factors secreted by decidual natural killer (dNK) cells from pregnancies at high risk of poor spiral artery remodelling different to those secreted from pregnancies at low risk?
Whitley, G S +11 more
core +1 more source
Natural killer T cells: Know thyself [PDF]
Proceedings of the National Academy of Sciences, 2007 There are two main reasons why natural killer T (NKT) cells fascinate immunologists. First, they exhibit a unique melange of properties found in innate immune cells as well as the properties of conventional T cells, part of adaptive immunity (1–4). Second, NKT cells exercise a determining influence on a variety of immune responses in mice, ranging from
Mitchell, Kronenberg, Laurent, Gapin
openaire +2 more sources
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Insulin-like growth factor I is an independent coregulatory modulator of natural killer (NK) cell activity. [PDF]
, 1996 We aimed to investigate the natural killer (NK) cell activity in hGH-deficient adults and to analyze the effect of insulin-like growth factor (IGF)-I in uivo and in vitro on NK cell activity.
Pachmann, K. +4 more
core +1 more source
Adipose invariant natural killer T cells [PDF]
Immunology, 2014 SummaryAdipose tissue is a dynamic organ that makes up a substantial proportion of the body; in severe obesity it can account for 50% of body mass. Details of the unique immune system resident in human and murine adipose tissue are only recently emerging, and so it has remained a largely unexplored and unappreciated immune site until now.
openaire +2 more sources
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source