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Pseudo Natural Products—Chemical Evolution of Natural Product Structure [PDF]

open access: yesAngewandte Chemie International Edition, 2021
Pseudo‐natural products (PNPs) combine natural product (NP) fragments in novel arrangements not accessible by current biosynthesis pathways. As such they can be regarded as non‐biogenic fusions of NP‐derived fragments.
George Karageorgis   +4 more
semanticscholar   +7 more sources

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]

open access: yesChemical Reviews, 2016
The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D.   +2 more
core   +3 more sources

Chemical Evolution of Natural Product Structure

open access: yesJournal of the American Chemical Society, 2022
Natural products are the result of Nature’s exploration of biologically relevant chemical space through evolution and an invaluable source of bioactive small molecules for chemical biology and medicinal chemistry.
Michael Grigalunas   +2 more
semanticscholar   +1 more source

The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems

open access: yesAntioxidants, 2022
The rapid spread of antibiotic resistance and lack of effective drugs for treating infections caused by multi-drug resistant bacteria in animal and human medicine have forced us to find new antibacterial strategies.
Chongshan Dai   +6 more
semanticscholar   +1 more source

Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy

open access: yesAntioxidants, 2022
With the recent development of chemical analysis technology, attention has been placed on natural light-sensitive compounds that exhibit photoreactivity to expand the structural diversity of natural product chemistry. Photochemical reactions that proceed
InWha Park   +6 more
doaj   +1 more source

SuperNatural 3.0—a database of natural products and natural product-based derivatives

open access: yesNucleic Acids Res., 2022
Natural products (NPs) are single chemical compounds, substances or mixtures produced by a living organism - found in nature. Evolutionarily, NPs have been used as healing agents since thousands of years and still today continue to be the most important ...
Kathleen Gallo   +6 more
semanticscholar   +1 more source

Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition

open access: yesMicrobiology Spectrum, 2022
Serine palmitoyltransferase catalyzes the first step of the sphingolipid biosynthesis. Recently, sphingolipid homeostasis has been connected to several human diseases, making serine palmitoyltransferases an interesting therapeutic target.
Sandra Hoefgen   +6 more
doaj   +1 more source

Natural product fragment combination to performance-diverse pseudo-natural products

open access: yesNature Communications, 2021
Natural product structure and fragment-based compound development inspire pseudo-natural product design through different combinations of a given natural product fragment set to compound classes expected to be chemically and biologically diverse.
Michael Grigalunas   +12 more
semanticscholar   +1 more source

Minerals Composition and Characterization of the Hatchery Eggshell Waste Treated with Different Preparation Methods

open access: yesJurnal Ilmu dan Teknologi Hasil Ternak, 2021
The preparation process needs to be carried out in the treatment of hatchery waste. The objective of the study was to determine the mineral content and characterization of the eggshell waste after preparation.
Ahmad Iskandar Setiyawan   +3 more
doaj   +1 more source

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris

open access: yesVirulence, 2022
Candida species are a major cause of invasive fungal infections. While Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life-threatening candidiasis, C.
Stefanie Allert   +8 more
doaj   +1 more source

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