Results 1 to 10 of about 12,812,720 (223)

Photochemical Approaches to Complex Chemotypes: Applications in Natural Product Synthesis. [PDF]

Chemical Reviews, 2016
The use of photochemical transformations is a powerful strategy that allows for the formation of a high degree of molecular complexity from relatively simple building blocks in a single step. A central feature of all light-promoted transformations is the
Kärkäs, Markus D., Porco, John A., Stephenson, Corey R.J.   +2 more
core   +3 more sources

Chemical Evolution of Natural Product Structure

Journal of the American Chemical Society, 2022
Natural products are the result of Nature’s exploration of biologically relevant chemical space through evolution and an invaluable source of bioactive small molecules for chemical biology and medicinal chemistry.
Michael Grigalunas, S. Brakmann, H. Waldmann   +2 more
semanticscholar   +1 more source

Facile Detection of Light-Controlled Radical Scavengers from Natural Products Using In Situ UV-LED NMR Spectroscopy

Antioxidants, 2022
With the recent development of chemical analysis technology, attention has been placed on natural light-sensitive compounds that exhibit photoreactivity to expand the structural diversity of natural product chemistry. Photochemical reactions that proceed
InWha Park, Goeun Park, Yoojin Choi, Seung-Woo Jo, Hak Cheol Kwon, Jin-Soo Park, Jin Wook Cha   +6 more
doaj   +1 more source

Pseudo Natural Products—Chemical Evolution of Natural Product Structure

Angewandte Chemie, 2021
Pseudo‐natural products (PNPs) combine natural product (NP) fragments in novel arrangements not accessible by current biosynthesis pathways. As such they can be regarded as non‐biogenic fusions of NP‐derived fragments.
George Karageorgis, Daniel J. Foley, Luca Laraia, S. Brakmann, H. Waldmann   +4 more
semanticscholar   +1 more source

Natural product fragment combination to performance-diverse pseudo-natural products

Nature Communications, 2021
Natural product structure and fragment-based compound development inspire pseudo-natural product design through different combinations of a given natural product fragment set to compound classes expected to be chemically and biologically diverse.
Michael Grigalunas, Annina Burhop, Sarah Zinken, A. Pahl, J. Gally, Niklas Wild, Yannik Mantel, S. Sievers, Daniel J. Foley, Rebecca Scheel, C. Strohmann, A. Antonchick, H. Waldmann   +12 more
semanticscholar   +1 more source

Desaturation of the Sphingofungin Polyketide Tail Results in Increased Serine Palmitoyltransferase Inhibition

Microbiology Spectrum, 2022
Serine palmitoyltransferase catalyzes the first step of the sphingolipid biosynthesis. Recently, sphingolipid homeostasis has been connected to several human diseases, making serine palmitoyltransferases an interesting therapeutic target.
Sandra Hoefgen, Alexander U. Bissell, Ying Huang, Fabio Gherlone, Luka Raguž, Christine Beemelmanns, Vito Valiante   +6 more
doaj   +1 more source

Minerals Composition and Characterization of the Hatchery Eggshell Waste Treated with Different Preparation Methods

Jurnal Ilmu dan Teknologi Hasil Ternak, 2021
The preparation process needs to be carried out in the treatment of hatchery waste. The objective of the study was to determine the mineral content and characterization of the eggshell waste after preparation.
Ahmad Iskandar Setiyawan, Diah Pratiwi, Mohammad Faiz Karimy, Safna Fauziah   +3 more
doaj   +1 more source

From environmental adaptation to host survival: Attributes that mediate pathogenicity of Candida auris

Virulence, 2022
Candida species are a major cause of invasive fungal infections. While Candida albicans, C. glabrata, C. parapsilosis, and C. tropicalis are the most dominant species causing life-threatening candidiasis, C.
Stefanie Allert, Daniela Schulz, Philipp Kämmer, Peter Großmann, Thomas Wolf, Sascha Schäuble, Gianni Panagiotou, Sascha Brunke, Bernhard Hube   +8 more
doaj   +1 more source

Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods

Molecules, 2021
Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai, Young-Joon Ko, Jin-Chul Kim, Cheol-Ho Pan, Keunwan Park   +4 more
doaj   +1 more source

Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening

BMC Bioinformatics, 2020
Background Despite continued efforts using chemical similarity methods in virtual screening, currently developed approaches suffer from time-consuming multistep procedures and low success rates.
Prasannavenkatesh Durai, Young-Joon Ko, Cheol-Ho Pan, Keunwan Park   +3 more
doaj   +1 more source