Results 91 to 100 of about 12,950,355 (371)

Equivariant K-theory, generalized symmetric products, and twisted Heisenberg algebra

, 2002
For a space X acted by a finite group $\G$, the product space $X^n$ affords a natural action of the wreath product $\Gn$. In this paper we study the K-groups $K_{\tG_n}(X^n)$ of $\Gn$-equivariant Clifford supermodules on $X^n$.
Wang, Weiqiang
core   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

The spatial organization of sphingofungin biosynthesis in Aspergillus fumigatus and its cross-interaction with sphingolipid metabolism

mBio
Sphingofungins are sphinganine analog mycotoxins acting as inhibitors of serine palmitoyl transferases, enzymes responsible for the first step in the sphingolipid biosynthesis.
Katarina Jojić, Fabio Gherlone, Zoltán Cseresnyés, Alexander U. Bissell, Sandra Hoefgen, Stefan Hoffmann, Ying Huang, Slavica Janevska, Marc Thilo Figge, Vito Valiante   +9 more
doaj   +1 more source

Conidial dihydroxynaphthalene melanin of the human pathogenic fungus Aspergillus fumigatus interferes with the host endocytosis pathway

Frontiers in Microbiology, 2011
Aspergillus fumigatus is the most important air-borne fungal pathogen of humans. The interaction of the pathogen with the host’s immune system represents a key process to understand pathogenicity.
Andreas eThywißen, Andreas eThywißen, Thorsten eHeinekamp, Thorsten eHeinekamp, Hans-Martin eDahse, Jeannette eSchmaler-Ripcke, Sandor eNietsche, Peter F. Zipfel, Axel A Brakhage, Axel A Brakhage   +9 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Data-based reconstruction of gene regulatory networks of fungal pathogens

Frontiers in Microbiology, 2016
In the emerging field of systems biology of fungal infection, one of the central roles belongs to the modelling of gene regulatory networks (GRNs). Utilising omics-data, GRNs can be predicted by mathematical modelling. Here, we review current advances of
Reinhard eGuthke, Silvia eGerber, Theresia eConrad, Sebastian eVlaic, Saliha eDurmus, Tunahan eCakir, Erdogan eSevilgen, Ekaterina eShelest, Jörg eLinde   +8 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

How to predict molecular interactions between species?

Frontiers in Microbiology, 2016
Organisms constantly interact with other species through physical contact which leads to chan-ges on the molecular level, for example the transcriptome. These changes can be monitored forall genes, with the help of high-throughput experiments such as RNA-
Jörg eLinde, Sylvie eSchulze, Jana eSchleicher, Reinhard eGuthke   +3 more
doaj   +1 more source

NPASS: natural product activity and species source database for natural product research, discovery and tool development

Nucleic Acids Res., 2017
There has been renewed interests in the exploration of natural products (NPs) for drug discovery, and continuous investigations of the therapeutic claims and mechanisms of traditional and herbal medicines.
Xian Zeng, Peng Zhang, Weidong He, Chu Qin, S. Chen, Lin Tao, Yali Wang, Ying Tan, Dan Gao, Bo-hua Wang, Zhe Chen, Weiping Chen, Yu Yang Jiang, Y. Chen   +13 more
semanticscholar   +1 more source

Hecke operators on Hilbert-Siegel modular forms

, 2007
We define Hilbert-Siegel modular forms and Hecke "operators" acting on them. As with Hilbert modular forms, these linear transformations are not linear operators until we consider a direct product of spaces of modular forms (with varying groups), modulo ...
Caulk, Suzanne, Walling, Lynne H.
core   +1 more source