Results 121 to 130 of about 4,422,072 (371)

Integration of single‐cell and bulk RNA‐sequencing data reveals the prognostic potential of epithelial gene markers for prostate cancer

open access: yesMolecular Oncology, EarlyView.
Prostate cancer is a leading malignancy with significant clinical heterogeneity in men. An 11‐gene signature derived from dysregulated epithelial cell markers effectively predicted biochemical recurrence‐free survival in patients who underwent radical surgery or radiotherapy.
Zhuofan Mou, Lorna W. Harries
wiley   +1 more source

The clinical spectrum of SMA‐PME and in vitro normalization of its cellular ceramide profile

open access: yesAnnals of Clinical and Translational Neurology, Volume 9, Issue 12, Page 1941-1952, December 2022., 2022
Abstract Objective The objectives of this study were to define the clinical and biochemical spectrum of spinal muscular atrophy with progressive myoclonic epilepsy (SMA‐PME) and to determine if aberrant cellular ceramide accumulation could be normalized by enzyme replacement.
Michelle M. Lee   +16 more
wiley   +1 more source

Monitoring and external control of pH in microfluidic droplets during microbial culturing

open access: yesMicrobial Cell Factories, 2020
Background Cell-based experimentation in microfluidic droplets is becoming increasingly popular among biotechnologists and microbiologists, since inherent characteristics of droplets allow high throughput at low cost and space investment.
Miguel Tovar   +4 more
doaj   +1 more source

Products of abstract polytopes [PDF]

open access: yesarXiv, 2016
Given two convex polytopes, the join, the cartesian product and the direct sum of them are well understood. In this paper we extend these three kinds of products to abstract polytopes and introduce a new product, called the topological product, which also arises in a natural way. We show that these products have unique prime factorization theorems.
arxiv  

Natural Products and Cancer

open access: yesNutrients, 2023
Natural and dietary compounds are known to offer protection and affect the pathogeneses of numerous chronic diseases [...]
openaire   +2 more sources

Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression

open access: yesMolecular Oncology, EarlyView.
Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park   +6 more
wiley   +1 more source

Blurring Boundaries: Toward the Collective Empathic Understanding of Product Requirements [PDF]

open access: yesarXiv, 2020
Within the agile paradigm, many software product companies create cross-functional product development teams that own their product or a defined set of product features. In contrast to development teams operating within a heavily-disciplined software development process, these product teams often require a deeper and, importantly, a collective ...
arxiv  

Non-formal star-exponential on contracted one-sheeted hyperboloids

open access: yes, 2015
In this paper, we exhibit the non-formal star-exponential of the Lie group SL(2,R) realized geometrically on the curvature contraction of its one-sheeted hyperboloid orbits endowed with its natural non-formal star-product.
Bieliavsky, Pierre   +3 more
core   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

open access: yesMolecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh   +6 more
wiley   +1 more source

A PRELIMINARY QUALITATIVE STUDY OF AN ALKALOID IN THE FRUIT OF TERONG BELANDA (Cyphomandra betacea, Cav)

open access: yesIndonesian Journal of Chemistry, 2010
Preliminary studies on Terong Belanda (C. betacea ) have been carried out in this investigation with an aim to examine the presence of an alkaloid in the fruit of Terong Belanda.
Fredryk Mandey   +2 more
doaj   +1 more source

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