Results 11 to 20 of about 13,213,530 (364)

Marine Natural Products [PDF]

ChemInform, 2002
AbstractFor Abstract see ChemInform Abstract in Full Text.
Blunt, J.W., Copp, B.R., Munro, M.H.G., Northcote, P.T., Prinsep, M.R.   +4 more
openaire   +10 more sources

Scalemic natural products

Natural Product Reports, 2023
In natural products, a low optical purity is not generally associated with a sloppy enzymatic activity, but rather with the co-expression of antipodal enzymes/directing proteins or, alternatively, with erosion by enzymatic or spontaneous reactions.
Mazzotta, Sarah, Rositano, Vincenzo, Senaldi, Luca, Bernardi, Anna, Allegrini, Pietro, Appendino, Giovanni   +5 more
openaire   +2 more sources

Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods

Molecules, 2021
Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai, Young-Joon Ko, Jin-Chul Kim, Cheol-Ho Pan, Keunwan Park   +4 more
doaj   +1 more source

Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening

BMC Bioinformatics, 2020
Background Despite continued efforts using chemical similarity methods in virtual screening, currently developed approaches suffer from time-consuming multistep procedures and low success rates.
Prasannavenkatesh Durai, Young-Joon Ko, Cheol-Ho Pan, Keunwan Park   +3 more
doaj   +1 more source

Iterative machine learning-based chemical similarity search to identify novel chemical inhibitors

Journal of Cheminformatics, 2023
Machine learning-based chemical screening has made substantial progress in recent years. However, these predictions often have low accuracy and high uncertainty when identifying new active chemical scaffolds.
Prasannavenkatesh Durai, Sue Jung Lee, Jae Wook Lee, Cheol-Ho Pan, Keunwan Park   +4 more
doaj   +1 more source

Natural products genomics [PDF]

Microbial Biotechnology, 2008
Secondary metabolites (or natural products) are often synthesized by multi‐modular, multi‐domain proteins called non‐ribosomal peptide synthetases (NRPS) and polyketide synthases (PKS). Various well‐known metabolites produced by microorganisms are listed in Table 1, and examples of structures are shown in Fig. 1. In particular, Streptomyces species are
Siezen, R.J., Khayatt, B.
openaire   +4 more sources

Self-Protection against the Sphingolipid Biosynthesis Inhibitor Fumonisin B₁ Is Conferred by a FUM Cluster-Encoded Ceramide Synthase

mBio, 2020
Fumonisin (FB) mycotoxins produced by species of the genus Fusarium detrimentally affect human and animal health upon consumption, due to the inhibition of ceramide synthase.
Slavica Janevska, Iuliia Ferling, Katarina Jojić, Julia Rautschek, Sandra Hoefgen, Robert H. Proctor, Falk Hillmann, Vito Valiante   +7 more
doaj   +1 more source

Natural Diagonal Riemannian Almost Product and Para-Hermitian Cotangent Bundles [PDF]

, 2009
We obtain the natural diagonal almost product and locally product structures on the total space of the cotangent bundle of a Riemannian manifold. We find the Riemannian almost product (locally product) and the (almost) para-Hermitian cotangent bundles of
A. Al-Aqeel, A. Andrada, A. Bonome, A. S. Dancer, Adriano Tomassini, C.-L. Bejan, Costantino Medori, D. Alekseevsky, D. E. Blair, D. V. Alekseevsky, D. V. Alekseevsky, D. V. Alekseevsky, D. V. Alekseevsky, D. V. Alekseevsky, Dmitrii V Alekseevsky, F. Defever, F. Etayo, G. B. Rizza, G. Santos-Garcia, I. Vaisman, J. E. Humpreys, J. J. Konderak, J. L. Koszul, J.-M. Morvan, M. A. Akivis, M. Gualtieri, M. Gualtieri, M.-A. Lawn, O. E. Arsen'eva, P. K. Rashevskii, P. Libermann, P. M. Gadea, P. M. Gadea, P. M. Gadea, P. Nurowski, R. Rosca, S. Donato, S. Erdem, S. Ianuş, S. Kaneyuki, S. Kaneyuki, S. Kaneyuki, S. Marchiafava, T. N. Bailey, Th. Krantz, V. Cortés, V. Cortés, V. Cruceanu, V. F. Kirichenko, V. F. Molchanov, V. Oproiu, Y. Matsushita, Z. Hou, Z. Hou, Z. Hou, Z. Olszak, Z. Olszak, Z. Olszak, Zi Xin Hou, В. Ф. Кириченко, В. Ф. Кириченко, Д. В. Алексеевский, О. Е. Арсеньева, П. К. Рашевский, Э. Б. Винберг   +64 more
core   +2 more sources

Bioactive Natural Products [PDF]

Journal of Chemistry, 2013
Bioactive natural products have never ceased to play an important role in the search of novel therapeutic agents. Natural products from the nature such as the plant and marine sources form an integral part of the living system, and they have existed ever since the beginning of life.Therefore, it is undeniable that works related to natural products ...
Hadi, A. Hamid A., Duru, Mehmet Emin, Martin-Diana, Ana B.   +2 more
openaire   +2 more sources

Does Osmotic Stress Affect Natural Product Expression in Fungi? [PDF]

, 2017
Acknowledgments: Russell Kerr acknowledges the assistance of Nadia Prigoda-Lee, Marius Grote, Kate McQuillan and Stephanie Duffy, and generous financial support from NSERC, the Canada Research Chair program, the Jeanne and Jean-Louis Lévesque Foundation ...
Bills, Gerald, Capon, Rob, Chi, Wei Chiung, Correa, Hebelin, Ebel, Rainer, Kerr, Russell, Overy, David, Pang, Ka Lai, Rateb, Mostafa, Roullier, Catherine, Shang, Zhuo   +10 more
core   +3 more sources