Results 61 to 70 of about 4,422,072 (371)

An integrative understanding of the large metabolic shifts induced by antibiotics in critical illness

open access: yesGut Microbes, 2021
Antibiotics are commonly used in the Intensive Care Unit (ICU); however, several studies showed that the impact of antibiotics to prevent infection, multi-organ failure, and death in the ICU is less clear than their benefit on course of infection in the ...
Andrea Marfil-Sánchez   +12 more
doaj   +1 more source

Natural products in endodontics

open access: yesSaudi Medical Journal, 2018
Herbal remedies are used throughout the world, either in earlier or in recent times. The number of studies on this alternative therapeutic system increased in the last decades. In this paper, the relevant literature on the use of natural products in root canal therapy is revised from a MEDLINE database search.
Amal A. Almohaimede, Ebtissam M. Al-Madi
openaire   +3 more sources

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

open access: yesFEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

How to predict molecular interactions between species?

open access: yesFrontiers in Microbiology, 2016
Organisms constantly interact with other species through physical contact which leads to chan-ges on the molecular level, for example the transcriptome. These changes can be monitored forall genes, with the help of high-throughput experiments such as RNA-
Jörg eLinde   +3 more
doaj   +1 more source

Natural Connection with Totally Skew-Symmetric Torsion on Riemannian Almost Product Manifolds [PDF]

open access: yes, 2011
On a Riemannian almost product manifold $(M,P,g)$ we consider a linear connection preserving the almost product structure $P$ and the Riemannian metric $g$ and having a totally skew-symmetric torsion.
DIMITAR MEKEROV   +11 more
core   +1 more source

Diphthamide synthesis is linked to the eEF2‐client chaperone machinery

open access: yesFEBS Letters, EarlyView.
The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr   +4 more
wiley   +1 more source

Aspergillus fumigatus melanins: Interference with the host endocytosis pathway and impact on virulence

open access: yesFrontiers in Microbiology, 2013
The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin.
Thorsten eHeinekamp   +6 more
doaj   +1 more source

Natural Product Studies [PDF]

open access: yes, 1962
Not ...
Hamilton, Richard J
core  

Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase

open access: yesFEBS Letters, EarlyView.
Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka   +6 more
wiley   +1 more source

Systems biology of fungal infection

open access: yesFrontiers in Microbiology, 2012
Elucidation of pathogenicity mechanisms of the most important human pathogenic fungi, Aspergillus fumigatus and Candida albicans, has gained great interest in the light of the steadily increasing number of cases of invasive fungal infections.A key ...
Fabian eHorn   +6 more
doaj   +1 more source

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