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Click Chemistry in Natural Product Modification [PDF]

open access: yesFrontiers in Chemistry, 2021
Click chemistry is perhaps the most powerful synthetic toolbox that can efficiently access the molecular diversity and unique functions of complex natural products up to now.
Xiang Zhang   +5 more
doaj   +3 more sources

Antibiofilm and antibacterial activities of lupinifolin in combination with protein synthesis inhibitors against methicillin-resistant Staphylococcus aureus [PDF]

open access: yesJournal of HerbMed Pharmacology, 2023
Introduction: Methicillin-resistant Staphylococcus aureus (MRSA)-derived biofilm formation is a crucial virulence factor, which essentially contributes to therapeutic challenges.
Parichart Kwaengmuang   +4 more
doaj   +1 more source

The chemistry of isoindole natural products [PDF]

open access: yesBeilstein Journal of Organic Chemistry, 2013
This review highlights the chemical and biological aspects of natural products containing an oxidized or reduced isoindole skeleton. This motif is found in its intact or modified form in indolocarbazoles, macrocyclic polyketides (cytochalasan alkaloids), the aporhoeadane alkaloids, meroterpenoids from Stachybotrys species and anthraquinone-type ...
Thomas Magauer, Klaus Speck
openaire   +5 more sources

The crystal structure of 13-(pyrazole-1-yl-4-carbonitrile)-matrine, C19H25N5O

open access: yesZeitschrift für Kristallographie - New Crystal Structures, 2021
C19H25N5O, monoclinic, P21 (no. 4), a = 16.0600(2) Å, b = 5.3992(1) Å, c = 19.8514(2) Å, β = 94.260(1)°, V = 1716.58(4) Å3, Z = 4, Rgt (F) = 0.0350, wRref(F2) = 0.0908, T = 100.00(10) K.
Li Jun-Jie   +8 more
doaj   +1 more source

A PRELIMINARY QUALITATIVE STUDY OF AN ALKALOID IN THE FRUIT OF TERONG BELANDA (Cyphomandra betacea, Cav)

open access: yesIndonesian Journal of Chemistry, 2010
Preliminary studies on Terong Belanda (C. betacea ) have been carried out in this investigation with an aim to examine the presence of an alkaloid in the fruit of Terong Belanda.
Fredryk Mandey   +2 more
doaj   +1 more source

Functionalized Nitroimidazole Scaffold Construction and Their Pharmaceutical Applications: A 1950–2021 Comprehensive Overview

open access: yesPharmaceuticals, 2022
Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first nitroimidazole as a natural product from Nocardia mesenterica with ...
Ria Gupta   +5 more
doaj   +1 more source

Isolation and characterization of starch from Limnophila aromatica

open access: yesHeliyon, 2019
Starch is one of the digestible natural polymers found in vascular plants. This natural polymer is the primary source of polysaccharides to produce energy for humans.
Cynthia Wijaya   +7 more
doaj   +1 more source

Structural insight into the bulge-containing KRAS oncogene promoter G-quadruplex bound to berberine and coptisine

open access: yesNature Communications, 2022
The G-quadruplex formed in KRAS oncogene promoter (KRAS-G4) is a transcriptional modulator and amenable to small molecule targeting. Herein, the authors report the NMR solution structures of a bulge-containing KRAS-G4 that bound to two small molecules ...
Kai-Bo Wang   +10 more
doaj   +1 more source

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