Results 61 to 70 of about 979,824 (352)
Novel concepts and methodologies in pseudo natural product chemistry [PDF]
, 2021 Natural products (NPs) are an inspiring source for chemical biology and drug discovery research, featuring complex and diverse structures. However, the chemical space explored by nature is limited by the biosynthetic precursors and machineries available ...
Liu, Jie
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A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Furan-site transformations of obacunone as potent insecticidal agents
Heliyon, 2018 Furan ring is a key pharmacophore for insecticidal activity of limoninoids. To develop natural-product-based insecticidal agents, a series of furan-site transformations (2, 3 and 3a–j) of obacunone were synthesized by selective bromination and following ...
Ping Xiang +5 more
doaj
Development and application of asymmetric organocatalytic Mukaiyama and vinylogous Mukaiyama-type reactions [PDF]
, 2018 This is the peer reviewed version of the following article: "Development and application of asymmetric organocatalytic Mukaiyama and vinylogous Mukaiyama-type reactions", Chemistry - A European Journal 24.43 (2018): 10906-10933 ,which has been published ...
Alemán, José +6 more
core +1 more source
Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Single‐cell insights into the role of T cells in B‐cell malignancies
FEBS Letters, EarlyView.Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley +1 more source
Synthetic and mechanistic studies of polyazole Cyclopeptide natural products: Aurantizolicin and Urukthapelstatin A [PDF]
, 2022 This PhD thesis describes the development of an effective total synthesis of the strongly cytotoxic polyazole cyclopeptide natural product aurantizolicin.
Oberheide, Ansgar
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Surfaceome: a new era in the discovery of immune evasion mechanisms of circulating tumor cells
Molecular Oncology, EarlyView.In the era of immunotherapies, many patients either do not respond or eventually develop resistance. We propose to pave the way for proteomic analysis of surface‐expressed proteins called surfaceome, of circulating tumor cells. This approach seeks to identify immune evasion mechanisms and discover potential therapeutic targets. Circulating tumor cells (
Doryan Masmoudi +3 more
wiley +1 more source
Chemical Constituents and Biological Activities of Ficus tikoua Bureau
Journal of Chemistry, 2022 Ficus tikoua Bureau (F. tikoua Bur.) is a perennial woody vine in the Moraceae family that has been used as a traditional folk medicine for centuries to treat many diseases such as chronic bronchitis, diarrhea, dysentery, rheumatism, and other ...
Liangliang Yao +4 more
doaj +1 more source
Teaching ‘natural product chemistry’ in Tanzania [PDF]
, 2016 Natural products ‘historically’ and ‘today’ have vast importance. This article describes the course ‘Natural Product Chemistry’, a new course in the 2011/2012 academic year in the Faculty of Natural and Applied Sciences at St.
Buchanan, Malcolm S., Sumary, Dominic P.
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