Results 91 to 100 of about 4,327,329 (308)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

TAT as a new marker and its use for noninvasive chemical biopsy in NASH diagnosis

Molecular Medicine
Background Early diagnosis of Nonalcoholic steatohepatitis (NASH) is crucial to prevent its progression to hepatocellular carcinoma, but its gold standard diagnosis still requires invasive biopsy.
Sihyang Jo, Jin-Mo Kim, Minshu Li, Han Sun Kim, Yong Jin An, Sunghyouk Park   +5 more
doaj   +1 more source

Legacy effects of continuous chloropicrin-fumigation for 3-years on soil microbial community composition and metabolic activity

AMB Express, 2017
Chloropicrin is widely used to control ginger wilt in China, which have an enormous impact on soil microbial diversity. However, little is known on the possible legacy effects on soil microbial community composition with continuous fumigation over ...
Shuting Zhang, Xiaojiao Liu, Qipeng Jiang, Guihua Shen, Wei Ding   +4 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Reduced Thioredoxin Regulates IL-1β Secretion via NLRP3 of IL-1β+ Alveolar Macrophages in COPD

Journal of Inflammation Research
Lueli Wang,1,* Rui Shi,1,* Zhaoliang Li,1 Ruoqiu Ma,1 Chongyu Wang,1,2 Changli Xu,1 Rong Guo,1 Chuang Xiao,1 Xiaohua Du,3 Weimin Yang1 1Yunnan Key Laboratory of Pharmacology for Natural Products, Kunming Medical University, Kunming ...
Wang L, Shi R, Li Z, Ma R, Wang C, Xu C, Guo R, Xiao C, Du X, Yang W   +9 more
doaj  

Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases

Experimental and Molecular Medicine
The glycerol 3-phosphate shuttle (GPS) is composed of two different enzymes: cytosolic NAD+-linked glycerol 3-phosphate dehydrogenase 1 (GPD1) and mitochondrial FAD-linked glycerol 3-phosphate dehydrogenase 2 (GPD2).
Sehyun Oh, Xuan Linh Mai, Jiwoo Kim, Arvie Camille V. de Guzman, Ji Yun Lee, Sunghyouk Park   +5 more
doaj   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Preparation, Characterization, and In Vitro Bioactivity of Artemisia capillaris Thunb. Leaf Protein Peptide Selenium Chelates

International Journal of Food Science
This study aimed to prepare Artemisia capillaris Thunb. leaf protein peptide selenium chelates (AP-Se) employing sodium selenite as a selenium (Se) source, with a focus on their structure and biological activities. Artemisia capillaris Thunb.
Wen-Lu Wei, Wen-Jun Wang, Chuan-Long Yu, Hui Chen, Su-Yun Lin, Ling-Li Chen   +5 more
doaj   +1 more source

LRR1 involved in the abscisic acid signaling pathway to regulate the early growth and development of Arabidopsis thaliana [PDF]

PeerJ
Background Living organisms possess the remarkable capacity to swiftly adapt to fluctuations in their environment. In the context of cell signal transduction, a significant challenge lies in ensuring the effective perception of external signals and the ...
Xiaoyang Xie, Lei Wei, Hongyuan Han, Bingnian Jing, Yuqing Liu, Yong Zhou, Ningjie Li, Xiao Li, Wei Wang   +8 more
doaj   +2 more sources

TARGETABLE MARKET SEGMENTS FOR NATURAL PORK PRODUCTS [PDF]

A survey of consumers established willingness to pay for natural pork products. Probit estimation was used to define targetable market segments for ham and pork chops. High-income, frequent pork consumers, and those most concerned about the use of growth
Grannis, Jennifer L., Thilmany, Dawn D.
core   +1 more source