Results 101 to 110 of about 12,894,217 (402)
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Autophagy and multidrug resistance in cancer
Chinese Journal of Cancer, 2017 Multidrug resistance (MDR) occurs frequently after long-term chemotherapy, resulting in refractory cancer and tumor recurrence. Therefore, combatting MDR is an important issue. Autophagy, a self-degradative system, universally arises during the treatment
Ying-Jie Li +7 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Amyloid as a natural product [PDF]
The Journal of Cell Biology, 2003 Amyloid fibrils, such as those found in Alzheimer's and the gelsolin amyloid diseases, result from the misassembly of peptides produced by either normal or aberrant intracellular proteolytic processing. A paper in this issue by Marks and colleagues (Berson et al., 2003) demonstrates that intra-melanosome fibrils are formed through normal biological ...
Kelly, Jeffery W., Balch, William E.
openaire +2 more sources
Novel quinazoline-1,2,3-triazole hybrids with anticancer and MET kinase targeting properties
Scientific Reports, 2023 Oncogenic activation of receptor tyrosine kinases (RTKs) such as MET is associated with cancer initiation and progression. We designed and synthesized a new series of quinazoline derivatives bearing 1,2,3-triazole moiety as targeted anticancer agents ...
Motahareh Mortazavi +8 more
doaj +1 more source
Plant Products as Biopesticides: Building On Traditional Knowledge of Vrkshayurveda: Traditional Indian Plant Science [PDF]
, 2008 Today there is a global search for alternatives to chemical pesticides and as part of this process there are various efforts to test the use and efficacy of natural products for pest control and crop protection. Our Centre has been involved in exploring
Arumugasamy, Mr. S. +3 more
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Aryne Acyl-Alkylation in the General and Convergent Synthesis of Benzannulated Macrolactone Natural Products: An Enantioselective Synthesis of (−)-Curvularin [PDF]
, 2010 A general approach for the synthesis of benzannulated macrolactone natural products utilizing an aryne acyl-alkylation reaction is described. Toward this end, the total syntheses of the natural products (−)-curvularin, curvulin, and (−)-diplodialide C ...
Stoltz, Brian M. +2 more
core +2 more sources
Natural Products and Derivatives as Potential Zika virus Inhibitors: A Comprehensive Review [PDF]
, 2023 Rosângela Santos Pereira +7 more
openalex +1 more source
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. [PDF]
, 2018 Bioactive natural products have evolved to inhibit specific cellular targets and have served as lead molecules for health and agricultural applications for the past century1-3.
Bat-Erdene, Undramaa +9 more
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