Results 101 to 110 of about 4,373,264 (365)
Molecular Oncology, EarlyView.This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini +10 more
wiley +1 more source
Density of polynomials in classes of functions on products of planar domains [PDF]
arXiv, 2014 We give sufficient conditions on planar domains for polynomials to be dense in the algebras A and A-infinity of the product of these domains, endowed with their natural topologies. We also characterize the uniform limits, with respect to the chordal metric, of polynomials on the product of the closures of these domains.
arxiv
Plant Products as Biopesticides: Building On Traditional Knowledge of Vrkshayurveda: Traditional Indian Plant Science [PDF]
, 2008 Today there is a global search for alternatives to chemical pesticides and as part of this process there are various efforts to test the use and efficacy of natural products for pest control and crop protection. Our Centre has been involved in exploring
Arumugasamy, Mr. S. +3 more
core
Network-analysis-guided synthesis of weisaconitine D and liljestrandinine. [PDF]
, 2015 General strategies for the chemical synthesis of organic compounds, especially of architecturally complex natural products, are not easily identified. Here we present a method to establish a strategy for such syntheses, which uses network analysis.
Gallego, GM +8 more
core +2 more sources
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source
LRR1 involved in the abscisic acid signaling pathway to regulate the early growth and development of Arabidopsis thaliana [PDF]
PeerJBackground Living organisms possess the remarkable capacity to swiftly adapt to fluctuations in their environment. In the context of cell signal transduction, a significant challenge lies in ensuring the effective perception of external signals and the ...
Xiaoyang Xie +8 more
doaj +2 more sources
Wreath products of cocommutative Hopf algebras [PDF]
arXiv, 2014 We define wreath products of cocommutative Hopf algebras, and show that they enjoy a universal property of classifying cleft extensions, analogous to the Kaloujnine-Krasner theorem for groups. We show that the group ring of a wreath product of groups is the wreath product of their group rings, and that (with a natural definition of wreath products of
arxiv
Knapsack problems in products of groups [PDF]
, 2015 The classic knapsack and related problems have natural generalizations to arbitrary (non-commutative) groups, collectively called knapsack-type problems in groups. We study the effect of free and direct products on their time complexity.
Frenkel, Elizaveta +2 more
core +1 more source
Molecular Oncology, EarlyView.Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu +11 more
wiley +1 more source
TAT as a new marker and its use for noninvasive chemical biopsy in NASH diagnosis
Molecular MedicineBackground Early diagnosis of Nonalcoholic steatohepatitis (NASH) is crucial to prevent its progression to hepatocellular carcinoma, but its gold standard diagnosis still requires invasive biopsy.
Sihyang Jo +5 more
doaj +1 more source