Results 21 to 30 of about 4,327,329 (308)

Evolutionary chemical binding similarity approach integrated with 3D-QSAR method for effective virtual screening

BMC Bioinformatics, 2020
Background Despite continued efforts using chemical similarity methods in virtual screening, currently developed approaches suffer from time-consuming multistep procedures and low success rates.
Prasannavenkatesh Durai, Young-Joon Ko, Cheol-Ho Pan, Keunwan Park   +3 more
doaj   +1 more source

Review: Marine natural products [PDF]

, 2005
This review covers the literature published in 2003 for marine natural products, with 619 citations (413 for the period January to December 2003) referring to compounds isolated from marine microorganisms and phytoplankton, green algae, brown algae, red ...
Blunt, John W., Copp, Brent R., Munro, Murray H.G., Northcote, Peter T., Prinsep, Michèle R.   +4 more
core   +3 more sources

Physalin A regulates the Nrf2 pathway through ERK and p38 for induction of detoxifying enzymes

BMC Complementary and Alternative Medicine, 2019
Background Physalin A isolated from Physalis alkekengi var. franchetii has been known to have many pharmacological properties. However, its effect through the Nrf2 pathway has not yet been elucidated.
Ji Min Shin, Kyung-Mi Lee, Hee Ju Lee, Ji Ho Yun, Chu Won Nho   +4 more
doaj   +1 more source

Strain prioritization and genome mining for enediyne natural products [PDF]

, 2016
The enediyne family of natural products has had a profound impact on modern chemistry, biology, and medicine, and yet only 11 enediynes have been structurally characterized to date.
Ben Shen, Christoph Rader, Dong Yang, Filip Van Nieuwerburgh, Hindra, Huiming Ge, Ivana Crnovčičć, Jeffrey D. Rudolf, Jeremy R. Lohman, Li-Xing Zhao, Qihui Teng, Tingting Huang, Xiangcheng Zhu, Xiaohui Yan, Xiuling Li, Yannick Gansemans, Yanwen Duan, Yi Jiang, Yong Huang   +18 more
core   +2 more sources

Circaea mollis Siebold & Zucc. Alleviates postmenopausal osteoporosis in a mouse model via the BMP-2/4/Runx2 pathway

BMC Complementary Medicine and Therapies, 2020
Background Circaea mollis Sieb. & Zucc. has been used as a traditional herbal medicine in Hani Ethnopharmacy and possesses anti-arthritic activities.
Ji Hye Park, Yang Ju Son, Chang Ho Lee, Chu Won Nho, Gyhye Yoo   +4 more
doaj   +1 more source

Novel Thioethers of Dihydroartemisinin Exhibiting Their Biological Activities

Heteroatom Chemistry, 2023
Eleven conjugates between dihydroartemisinin (DHA) with thiols containing both ether and thioether bonds were designed, synthesized by a two-step procedure including etherification and S-alkylation.
Ngoc Hung Truong, Thi Hong Ha Tran, Kim Chi Hoang, Duc Bao Ninh, Viet Duc Le, Duc Anh Le, Van Chinh Luu   +6 more
doaj   +1 more source

Identification of Tyrosinase Inhibitors and Their Structure-Activity Relationships via Evolutionary Chemical Binding Similarity and Structure-Based Methods

Molecules, 2021
Tyrosinase is an enzyme that plays a crucial role in the melanogenesis of humans and the browning of food products. Thus, tyrosinase inhibitors that are useful to the cosmetic and food industries are required.
Prasannavenkatesh Durai, Young-Joon Ko, Jin-Chul Kim, Cheol-Ho Pan, Keunwan Park   +4 more
doaj   +1 more source

Soil Acidification Aggravates the Occurrence of Bacterial Wilt in South China

Frontiers in Microbiology, 2017
Soil acidification is a major problem in modern agricultural systems and is an important factor affecting the soil microbial community and soil health. However, little is known about the effect of soil acidification on soil-borne plant diseases.
Chen Xu, Wei Ding, Shili Li, Yongqin Liu, Jiao Wang, Liang Yang, Shuting Zhang   +6 more
doaj   +1 more source

Water extract of pomegranate ash–I2 as sustainable system for external oxidant/metal/catalyst-free oxidative iodination of (hetero)arenes

Green Chemistry Letters and Reviews, 2021
Utilization of waste-derived materials for industrially pertinent chemical transformations is highly challenging and offers sustainable solution to waste management.
Rama Moorthy Appa, Bandameeda Ramesh Naidu, Derangula Venkateswarlu, Marlia M. Hanafiah, Sivarama Krishna Lakkaboyana, Jangam Lakshmidevi, Katta Venkateswarlu   +6 more
doaj   +1 more source

Ternatin and improved synthetic variants kill cancer cells by targeting the elongation factor-1A ternary complex. [PDF]

, 2015
Cyclic peptide natural products have evolved to exploit diverse protein targets, many of which control essential cellular processes. Inspired by a series of cyclic peptides with partially elucidated structures, we designed synthetic variants of ternatin,
Carelli, Jordan D, Jain, Rishi K, Merrick, William C, Miller, Howard R, Ross, Nathan T, Sethofer, Steven G, Simard, Jillian L, Smith, Geoffrey A, Taunton, Jack   +8 more
core   +2 more sources