Results 61 to 70 of about 12,894,217 (402)

Anticancer Drug Discovery Based on Natural Products: From Computational Approaches to Clinical Studies

Biomedicines
Globally, malignancies cause one out of six mortalities, which is a serious health problem. Cancer therapy has always been challenging, apart from major advances in immunotherapies, stem cell transplantation, targeted therapies, hormonal therapies ...
Pritee Chunarkar-Patil, M. Kaleem, R. Mishra, Subhasree Ray, Aftab Ahmad, Devvret Verma, S. Bhayye, Rajni Dubey, H. Singh, Sanjay Kumar   +9 more
semanticscholar   +1 more source

Review on natural products databases: where to find data in 2020

Journal of Cheminformatics, 2020
Natural products (NPs) have been the centre of attention of the scientific community in the last decencies and the interest around them continues to grow incessantly.
Maria Sorokina, C. Steinbeck
semanticscholar   +1 more source

Natural Products and Cancer

Nutrients, 2023
Natural and dietary compounds are known to offer protection and affect the pathogeneses of numerous chronic diseases [...]
openaire   +2 more sources

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Techniques for extraction and isolation of natural products: a comprehensive review

Chinese Medicine, 2018
Natural medicines were the only option for the prevention and treatment of human diseases for thousands of years. Natural products are important sources for drug development.
Qing-Wen Zhang, Ligen Lin, W. Ye
semanticscholar   +1 more source

Slim and scum: Natural products from land and sea [PDF]

, 2000
To a natural-products chemist, the term "natural products" does not refer to all compounds from natural sources, as the name might imply. It is specifically used to refer to compounds known as secondary metabolites, structurally complex molecules, often ...
Prinsep, Michèle R.
core   +1 more source

Euphorbia-derived natural products with potential for use in health maintenance [PDF]

, 2019
Euphorbia genus (Euphorbiaceae family), which is the third largest genus of angiosperm plants comprising ca. 2000 recognized species, is used all over the world in traditional medicine, especially in the traditional Chinese medicine. Members of this taxa
Adedoyin, Aleksandrov, Bard, Barla, Baslas, Chanda, Colley, Cui, Dabholkar, Deveci, Gaioni, Govaerts, Gupta, Hargreaves, Hassan, Jing, Kumara Swamy, Li, Lu, Ma, Mali, Mali, Merza, Mir, Ogbulie, Ogunlesi, Pascal, Polygenis-bigendako, Ram, Rehman, Shamsabadipour, Sharanappa, Suffness, Özbilgin, Özbilgin   +34 more
core   +4 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Artemisia argyi polysaccharide alleviates intestinal inflammation and intestinal flora dysbiosis in lipopolysaccharide-treated mice

Food & Medicine Homology
Artemisia argyi polysaccharide (AAP) is an important active component extracted from the leaves of A. argyi. Currently, the effects of AAP in mouse model of intestinal inflammation are unclear.
Er-Juan Ning, Chao-Wei Sun, Xue-Fang Wang, Ling Chen, Fei-Fei Li, Li-Xian Zhang, Lu-Peng Wang, Yan-Ni Ma, Jie Zhu, Xiao Li, Wei Wang   +10 more
doaj   +1 more source