Results 61 to 70 of about 4,373,264 (365)

Slim and scum: Natural products from land and sea [PDF]

, 2000
To a natural-products chemist, the term "natural products" does not refer to all compounds from natural sources, as the name might imply. It is specifically used to refer to compounds known as secondary metabolites, structurally complex molecules, often ...
Prinsep, Michèle R.
core   +1 more source

Geographic variation in walking activity in the red flour beetle Tribolium castaneum

Population Ecology, EarlyView.
This study examined whether there is geographic variation in field populations, focusing on the moving activity in the red flour beetle Tribolium castaneum. Results showed significant differences in moving activity among field populations but no correlation with latitude or meteorological factors.
Kentarou Matsumura
wiley   +1 more source

Analysis and Evaluation of Nutrient Components, Bioactive Substances and Heavy Metal Content of Stropharia rugosoannulata in Bo’ai County

Shipin gongye ke-ji, 2022
This study systematically determined the nutrient components, bioactive substances and heavy metal content of Stropharia rugosoannulata in Bo’ai County, and its nutritional value was analyzed and evaluated.
Bingnian JING, Xia CHANG, Lei WEI, Xiaoyang XIE, Yong ZHOU, Zhiyao WANG, Yuqing LIU, Wei WANG   +7 more
doaj   +1 more source

Dendritic cells steering antigen and leukocyte traffic in lymph nodes

FEBS Letters, EarlyView.
Dendritic cells are key players in the activation of T cells and their commitment to effector function. In this In a Nutshell Review, we will discuss how dendritic cells guide the trafficking of antigen and leukocytes in the lymph node, thus influencing T‐cell activation processes. Dendritic cells (DCs) play a central role in initiating and shaping the
Enrico Dotta, Agnieszka Katarzyna Maciola, Tania Baccega, Giulia Pasqual   +3 more
wiley   +1 more source

InertDB as a generative AI-expanded resource of biologically inactive small molecules from PubChem

Journal of Cheminformatics
The development of robust artificial intelligence (AI)-driven predictive models relies on high-quality, diverse chemical datasets. However, the scarcity of negative data and a publication bias toward positive results often hinder accurate biological ...
Seungchan An, Yeonjin Lee, Junpyo Gong, Seokyoung Hwang, In Guk Park, Jayhyun Cho, Min Ju Lee, Minkyu Kim, Yun Pyo Kang, Minsoo Noh   +9 more
doaj   +1 more source

A mass spectrometry-guided genome mining approach for natural product peptidogenomics. [PDF]

, 2011
Peptide natural products show broad biological properties and are commonly produced by orthogonal ribosomal and nonribosomal pathways in prokaryotes and eukaryotes.
Cimermancic, Peter, Dorrestein, Pieter C, Fenical, William, Fischbach, Michael A, Kersten, Roland D, Moore, Bradley S, Nam, Sang-Jip, Xu, Yuquan, Yang, Yu-Liang   +8 more
core  

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Imidazopyridine hydrazone derivatives exert antiproliferative effect on lung and pancreatic cancer cells and potentially inhibit receptor tyrosine kinases including c-Met

Scientific Reports, 2021
Aberrant activation of c-Met signalling plays a prominent role in cancer development and progression. A series of 12 imidazo [1,2-α] pyridine derivatives bearing 1,2,3-triazole moiety were designed, synthesized and evaluated for c-Met inhibitory ...
Tahereh Damghani, Fatemeh Moosavi, Mehdi Khoshneviszadeh, Motahareh Mortazavi, Somayeh Pirhadi, Zahra Kayani, Luciano Saso, Najmeh Edraki, Omidreza Firuzi   +8 more
doaj   +1 more source

Antitumor Activity of Pulvomycin via Targeting Activated-STAT3 Signaling in Docetaxel-Resistant Triple-Negative Breast Cancer Cells

Biomedicines, 2021
Although docetaxel-based regimens are common and effective for early-stage triple-negative breast cancer (TNBC) treatment, acquired drug resistance frequently occurs.
Woong Sub Byun, Eun Seo Bae, Jinsheng Cui, Hyen Joo Park, Dong-Chan Oh, Sang Kook Lee   +5 more
doaj   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source