Results 71 to 80 of about 12,832,013 (404)

Blood mitochondrial metabolism predicts flight performance without lasting effects of early-life thyroid hormones

open access: yesiScience
Summary: Early-life conditions can shape adult phenotypes by influencing processes linked to energetic homeostasis. Thyroid hormones (THs) enhance mitochondrial electron transport chain capacity (ETS) in fledglings, but whether this effect is permanent ...
Marlene Oefele   +3 more
doaj   +1 more source

The Bologna agreement is not suitable for medical education : a German view [PDF]

open access: yes, 2010
Central elements of the Bologna declaration have been implemented in a huge variety of curricula in humanities, social sciences, natural sciences and engineering sciences at German universities. Overall the results have been nothing less than disastrous.
Pfeilschifter, Josef Martin (Prof. Dr.)
core  

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Computer-aided robotics for applications in fracture reduction surgery: Advances, challenges, and opportunities

open access: yesiScience
Summary: The advancement of information technology and AI has boosted global economic and social development. Robot systems (RS) and computer-aided technology (CAT) are used in various domains, including social production and human existence. Traditional
Xianzheng Zhou   +5 more
doaj   +1 more source

Causal theories, models and evidence in economics—some reflections from the natural sciences

open access: yes, 2017
Models have been extensively analysed in economic methodology, notably their degree of ability to provide explanations. This paper takes a complementary, comparative approach, examining theory development in the natural sciences.
M. Joffe
semanticscholar   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Dynamics of the oral microbiome during orthodontic treatment and antimicrobial advances for orthodontic appliances

open access: yesiScience
Summary: The oral microbiome plays an important role in human health, and an imbalance of the oral microbiome could lead to oral and systemic diseases. Orthodontic treatment is an effective method to correct malocclusion.
Qin Niu   +6 more
doaj   +1 more source

Alaska's Food (In)Security, Climate Change and the Boreal Forest, Biomass and Hydrocarbons [PDF]

open access: yes, 2010
[Geography] -- AMSA: the future of arctic marine shipping: With more shipping traffic in the north and greater marine access due to the retreat of Arctic sea ice, the Arctic states needed to develop a strategy to protect the maritime Arctic, its people ...
School of Natural Resources and Agricultural Sciences, Agricultural and Forestry Experiment Station, University of Alaska Fairbanks
core  

A preliminary assessment of water partitioning and ecohydrological coupling in northern headwaters using stable isotopes and conceptual runoff models [PDF]

open access: yes, 2015
Funded by European Research Council ERC. Grant Number: GA 335910 VEWA Swedish Science Foundation (SITES) Future Forest Formas (ForWater) SKB the Kempe foundation Environment Canada the Garfield Weston Foundation the Natural Sciences and Engineering ...
Buttle, James   +9 more
core   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

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