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Developing therapeutic strategies to target MCL1 and BCLXL in lethal prostate cancer. [PDF]

open access: yesiScience
Westaby D   +26 more
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A phase 1 study of the combination of BH3-mimetic, navitoclax, and mTORC1/2 inhibitor, vistusertib, in patients with advanced solid tumors. [PDF]

open access: yesCancer Chemother Pharmacol
Scott SC   +11 more
europepmc   +1 more source

<i>In silico</i> evaluation of vitamin D3 as a dual inhibitor of CDK2 and Bcl-2 in colorectal cancer. [PDF]

open access: yesOpen Vet J
Shobahah J   +4 more
europepmc   +1 more source

The Yin and Yang of cellular senescence in ischemia-induced myocardial injury. [PDF]

open access: yesTrends Cardiovasc Med
Wolff von Gudenberg R   +6 more
europepmc   +1 more source
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Senolytic Agent Navitoclax Inhibits Angiotensin II-Induced Heart Failure in Mice

Journal of Cardiovascular Pharmacology, 2020
Abstract: Navitoclax, which is a type of senolytic drug, selectively eliminates senescent cells. This study aimed to evaluate the therapeutic potential of navitoclax in treatment of angiotensin II (Ang II)-induced heart failure in mice. Navitoclax or vehicle was administrated in mice with Ang II-induced heart failure.
Kangni Jia, Ao Liu, Lin Lu
exaly   +3 more sources

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