Results 141 to 150 of about 7,693 (199)

Identification of endometrial cancer biomarkers using weighted gene coexpression network analysis and machine learning. [PDF]

BMC Cancer
Wang H, Gong Y, Han X, Zeng J.
europepmc   +1 more source

Navitoclax, a Bcl-2/xL Inhibitor, and YM155, a Survivin Inhibitor, in Combination with Carboplatin, Effectively Inhibit Ovarian Cancer Tumor Growth. [PDF]

Mol Cancer Ther
Kenny HA, Ip CKM, Kelliher L, Samantaray T, Kordylewicz K, Hoffmann R, Rauch S, Malacrida B, Skingsley SLP, Balkwill FR, Battistini C, Cavallaro U, Wiedemeyer WR, Lengyel E.   +13 more
europepmc   +1 more source

Targeting senescent microglia in progressive multiple sclerosis: a geroscience-informed approach. [PDF]

Front Immunol
Atkinson J, Dokiburra A, Groover H, Godbout JP, Segal BM, Zhang Y.   +5 more
europepmc   +1 more source

Targeting Bcl-xL with Navitoclax Effectively Eliminates Senescent Tumor Cells That Appear Following CEP-1347-Induced Differentiation of Glioma Stem Cells. [PDF]

Int J Mol Sci
Takenouchi S, Ito Y, Nakamura K, Nakagawa-Saito Y, Mitobe Y, Togashi K, Suzuki S, Sugai A, Sonoda Y, Kitanaka C, Okada M.   +10 more
europepmc   +1 more source

Genomic analysis and selective small molecule inhibition identifies BCL-X as a critical survival factor in a subset of colorectal cancer [PDF]

core   +1 more source

Mitochondrial priming in therapy-induced senescence: implications for CAR-T/NK immunosenolytic therapy. [PDF]

Front Immunol
Menendez JA, Lupu R, Martin-Castillo B, Sardanyés J, Alarcón T, Verdura S, Cuyàs E.   +6 more
europepmc   +1 more source

Direct Co-Targeting of Bcl-xL and Mcl-1 Exhibits Synergistic Effects in AR-V7-Expressing CRPC Models. [PDF]

Cancer Res Commun
Brim BC, Leon AF, Beatson EL, Kindrick JD, Bhadresha K, Zhang X, Napoli GC, Risdon EN, Schmidt KT, Wilson KM, McKnight C, Beck E, Klumpp-Thomas C, Ceribelli M, Yin J, Sowalsky AG, Price DK, Chau CH, Thomas CJ, Figg WD.   +19 more
europepmc   +1 more source

BH3 mimetics targeting BCL-XL have efficacy in solid tumors with RB1 loss and replication stress. [PDF]

Nat Commun
Varkaris A, Wang K, Nouri M, Kozlova N, Schmidt DR, Stavridi A, Arai S, Ambrosio N, Poluben L, Jimenez-Vacas JM, Westaby D, Carmichael J, Xie F, Figueiredo I, Buroni L, Neeb A, Gurel B, Chevalier N, Brown L, Voznesensky O, Chen SY, Russo JW, Yuan X, Juric D, Beltran H, De Bono JS, Vander Heiden MG, Einstein DJ, Muranen T, Corey E, Sharp A, Balk SP.   +31 more
europepmc   +1 more source

BH3 mimetic drugs overcome the microenvironment-induced resistance to crizotinib in ALK+ anaplastic large cell lymphoma. [PDF]

Blood Adv
Pignataro C, Zoppoli P, Cappelli LV, Yoffe L, Moretti M, Izzo M, Mallia S, Kayembe C, Taylor A, Petrillo G, Affinito A, Quintavalle C, De Luca G, Mascolo M, Verde S, Fraticelli A, Ciarrocchi A, Salerno P, De Smaele E, Campese AF, Fragliasso V, Foà R, Merla G, Inghirami G, Condorelli G, Fiore D.   +25 more
europepmc   +1 more source