Results 121 to 130 of about 7,693 (199)

470 Senolytic therapies as treatments for posttraumatic epilepsy

Journal of Clinical and Translational Science
Objectives/Goals: Increased numbers of senescent cells have been detected in both traumatic brain injury and epilepsy, suggesting them as targets for therapeutic intervention for treating posttraumatic epilepsy (PTE) and underscoring the need for ...
Max Stevenson, Mark Burns
doaj   +1 more source

HSF1 is a prognostic determinant and therapeutic target in intrahepatic cholangiocarcinoma

Journal of Experimental & Clinical Cancer Research
Background Intrahepatic cholangiocarcinoma (iCCA) is a lethal primary liver tumor characterized by clinical aggressiveness, poor prognosis, and scarce therapeutic possibilities. Therefore, new treatments are urgently needed to render this disease curable.
Antonio Cigliano, Isabella Gigante, Marina Serra, Gianpaolo Vidili, Maria M. Simile, Sara Steinmann, Francesco Urigo, Eleonora Cossu, Giovanni M. Pes, Maria P. Dore, Silvia Ribback, Egle P. Milia, Elena Pizzuto, Serena Mancarella, Li Che, Rosa M. Pascale, Gianluigi Giannelli, Matthias Evert, Xin Chen, Diego F. Calvisi   +19 more
doaj   +1 more source

Senólisis en el corazón senescente: Una revisión de la literatura actual

Revista Científica CMDLT
La senescencia celular se ha consolidado como un mecanismo biológico fundamental en la patogénesis de las enfermedades cardiovasculares (ECV) asociadas al envejecimiento.
Luis Armando Tirado Fontaines, Daniel Ernesto Foldats   +1 more
doaj   +2 more sources

ONC212, alone or in synergistic conjunction with Navitoclax (ABT-263), promotes cancer cell apoptosis via unconventional mitochondrial-independent caspase-3 activation

Cell Communication and Signaling
Mitochondria-targeting agents, known as mitocans, are emerging as potent cancer therapeutics due to pronounced metabolic and apoptotic adaptations in the mitochondria of cancer cells.
Vishal Basu, Shabnam, Yamini Murghai, Maqsood Ali, Swetangini Sahu, Bhupendra K. Verma, Mahendra Seervi   +6 more
doaj   +1 more source

GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis [PDF]

, 2016
A Duensing, A Ruiz i Altaba, AJ Olaharski, AM Snijders, B Zhivotovsky, C Mantel, C Tse, CE Jefford, D Duelli, D Hanahan, D Janisson-Dargaud, D Lodygin, D Lodygin, D Zhang, DA Nelson, DP Lane, E Gemenetzidis, E Kump, EC Pavarino, EH Epstein, EW Wilker, F Borel, G Regl, G Regl, GR Ribeiro, H Deng, H Hermeking, H Rajagopalan, I Vitale, J Ji, JA Sterling, JC Strefford, Jo Vandesompele, JS Lanni, K Fukasawa, KJ Ashton, L O'Driscoll, M Castedo, M Grachtchouk, M Grachtchouk, M Hirotsu, M Lobrich, M Tojo, M Vogler, MA Dickson, ME Hutchin, MS Ikram, MT Teh, NJ Ganem, P Erb, PA Beachy, PC Galipeau, PR Andreassen, Q Shi, RL Margolis, S Dhar, S Thiyagarajan, SJ Miller, SL Thompson, SS Jayaraman, T Fujiwara, T Mazumdar, VI Alexaki, X Mao, Y Jin, Z Storchova, Z Storchova, ZA Stewart   +67 more
core   +1 more source

Mcl-1 confers protection of Her2-positive breast cancer cells to hypoxia: therapeutic implications [PDF]

, 2016

core   +1 more source

Disproportionality Analysis of Hematologic Adverse Event Signals Associated with Venetoclax in Combination with Senescence-Inducing Chemotherapy. [PDF]

J Clin Med
Saleh T, Ramadan M, Alsoud A, Al Shboul S.   +3 more
europepmc   +1 more source

Superior anti-tumor activity of the MDM2 antagonist idasanutlin and the Bcl-2 inhibitor venetoclax in p53 wild-type acute myeloid leukemia models [PDF]

, 2016

core   +1 more source

Efficacy and safety of Ruxolitinib-based combination therapy in the patients with Myelofibrosis (MF): a systematic review and meta-analysis. [PDF]

Ann Med
Tan S, Li Y, Cao Y, Sun W, Hui W.
europepmc   +1 more source

Cellular senescence and metabolic aging in type 2 diabetes: mechanistic insights and translational implications. [PDF]

Front Endocrinol (Lausanne)
Syed AR, Aloti RA, Awad BJ, Alghoul WII, Hassan MAMSA, Kharoufeh A, Rangraze I.   +6 more
europepmc   +1 more source