Results 101 to 110 of about 7,693 (199)

Identification of senescence-related genes for potential therapeutic biomarkers of atrial fibrillation by bioinformatics, human histological validation, and molecular docking

Heliyon
Background: Cellular senescence is pivotal in the occurrence and progression of atrial fibrillation (AF). This study aimed to identify senescence-related genes that could be potential therapeutic biomarkers for AF.
Jingmeng Liu, Taojie Zhou, Yangyang Bao, Changjian Lin, Qiujing Chen, Yang Dai, Ning Zhang, Wenqi Pan, Qi Jin, Lin Lu, Qiang Zhao, Tianyou Ling, Liqun Wu   +12 more
doaj   +1 more source

Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma. [PDF]

, 2019
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer histotype, characterized by high biological aggressiveness and scarce treatment options.
Calvisi, Diego F, Che, Li, Chen, Xin, Evert, Matthias, Hu, Junjie, Liu, Xianqiong, Lu, Xinjun, Song, Xinhua, Su, Tao, Utpatel, Kirsten, Wang, Jingxiao, Wang, Pan, Xu, Meng, Zhang, Jie, Zhang, Yi   +14 more
core   +1 more source

NFκB signaling in alveolar rhabdomyosarcoma

Disease Models & Mechanisms, 2017
Alveolar rhabdomyosarcoma (aRMS) is a pediatric soft tissue cancer commonly associated with a chromosomal translocation that leads to the expression of a Pax3:Foxo1 or Pax7:Foxo1 fusion protein, the developmental underpinnings of which may give clues to ...
Megan M. Cleary, Atiya Mansoor, Teagan Settelmeyer, Yuichi Ijiri, Katherine J. Ladner, Matthew N. Svalina, Brian P. Rubin, Denis C. Guttridge, Charles Keller   +8 more
doaj   +1 more source

On BH3 mimetics and Ca2+ signaling [PDF]

, 2017
BH3 mimetics are anticancer agents that reproduce the spatial arrangement of the BH3 domain of Bcl-2 family proteins. Just like the BH3-only proteins, these compounds bind to the hydrophobic cleft of the pro-survival Bcl-2 members such as Bcl-2 or Bcl-xL,
Ferdek, Pawel, Jakubowska, Monika
core   +1 more source

MUC1 Aptamer‐Capped Mesoporous Silica Nanoparticles for Navitoclax Resistance Overcoming in Triple‐Negative Breast Cancer

Chemistry – A European Journal, 2020
AbstractTriple‐negative breast cancer (TNBC) is the most aggressive breast cancer subtype. In the last years, navitoclax has emerged as a possible treatment for TNBC. Nevertheless, rapid navitoclax resistance onset has been observed thorough Mcl‐1 overexpression.
Gema Vivo‐Llorca, Vicente Candela‐Noguera, María Alfonso, Alba García‐Fernández, Mar Orzáez, Félix Sancenón, Ramón Martínez‐Máñez   +6 more
openaire   +6 more sources

Senolytic therapy increases replicative capacity by eliminating senescent endothelial cells

Experimental Gerontology
Aging is the greatest risk factor for cardiovascular diseases (CVD) and is characterized by inflammation, oxidative stress, and cellular senescence. Cellular senescence is a state of persistent cell cycle arrest triggered by stressors such as DNA damage ...
Hossein Abdeahad, Denisse G. Moreno, Samuel I. Bloom, Hui Huang, Lisa A. Lesniewski, Anthony J. Donato   +5 more
doaj   +1 more source

Mitochondria, telomeres and cell senescence: Implications for lung ageing and disease

, 2017
Cellular senescence, the irreversible loss of replicative capacity in somatic cells, plays a causal role in the development of age-related pathology and in a number of age-related chronic inflammatory diseases.
Barnes, PJ, Birch, J, Passos, JF
core   +1 more source

S55746 is a novel orally active BCL-2 selective and potent inhibitor that impairs hematological tumor growth [PDF]

, 2018
International audienceEscape from apoptosis is one of the major hallmarks of cancer cells. The B-cell Lymphoma 2 (BCL-2) gene family encodes pro-apoptotic and anti-apoptotic proteins that are key regulators of the apoptotic process. Overexpression of the
Amiot, Martine, Bruno, Alain, Casara, Patrick, Chanrion, Maïa, Chen, Ijen, Claperon, Audrey, Cohen, Gerald M, Colland, Frédéric, Davidson, James, Diguarher, Thierry Le, Dokurno, Pawel, Dyer, Martin JS, Geneste, Olivier, Girard, Anne-Marie, Gouill, Steven Le, Graham, Christopher, Gravé, Fabienne, Guasconi, Ghislaine, Henlin, Jean-Michel, Hickman, John A., Hubbard, Roderick, Kraus-Berthier, Laurence, Lysiak-Auvity, Gaëlle, Matassova, Natalia, Maïga, Sophie, Morris, Erick, Murray, James, Pedder, Christopher, Qiu, Shumei, Rocchetti, Franscesca, Schneider, Emilie, Starck, Jérôme-Benoît, Studeny, Aurélie, Toumelin-Braizat, Gaëtane Le, Vogler, Meike, Wang, Youzhen, Whitehead, Neil, Wood, Mike   +37 more
core   +3 more sources

Advocating the need of a systems biology approach for personalised prognosis and treatment of B-CLL patients [PDF]

, 2012
The clinical course of B-CLL is heterogeneous. This heterogeneity leads to a clinical dilemma: can we identify those patients who will benefit from early treatment and predict the survival?
Goltsov, Alexey, Khalil, Hilal S., Mitev, Vanio, Scott, Fiona, Sproul, Anne, Tummala, Hemanth, Zhelev, Nikolai   +6 more
core   +3 more sources

Prediction of Binding Mode of Secondary Metabolites in Apium graveolens to Bcl-2

Pharmacology and Clinical Pharmacy Research, 2017
Developing new cytotoxic agent which has minimal effect against normal cell is required to reduce the side effects obtained from the existing chemotherapy agents.
Kee P. Shan, Nyi M. Saptarini, Jutti Levita   +2 more
doaj   +1 more source