Results 91 to 100 of about 7,693 (199)

Human platelet lysate improves human cord blood derived ECFC survival and vasculogenesis in three dimensional (3D) collagen matrices [PDF]

, 2015
Human cord blood (CB) is enriched in circulating endothelial colony forming cells (ECFCs) that display high proliferative potential and in vivo vessel forming ability.
Ferkowicz, Michael J., Kim, Hyojin, Prasain, Nutan, Vemula, Sasidhar, Voytik-Harbin, Sherry L., Yoder, Mervin C., Yoshimoto, Momoko   +6 more
core   +1 more source

The Roles of Macrophage Lineage Cells (MLCs) in Brain Aging

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
This review highlights the critical role of macrophage lineage cells (MLCs), including microglia, border‐associated macrophages (BAMs), and CNS‐infiltrating monocyte‐derived macrophages (MDMs), in brain aging. It explores the drivers and propagation of MLCs senescence and discusses potential therapeutic strategies targeting MLCs senescence.
Qin Qin, Liubin Zhang, Manning Guo, Danli Lu, Yuxin Liu, Zihong Wang, Mengyan Hu, Shisi Wang, Xinmei Kang, Haotong Yi, Wei Qiu, Zhengqi Lu, Wei Cai   +12 more
wiley   +1 more source

Oncogenic senescence: a multi-functional perspective. [PDF]

, 2017
Cellular senescence is defined as an irreversible growth arrest with the acquisition of a distinctive secretome. The growth arrest is a potent anticancer mechanism whereas the secretome facilitates wound healing, tissue repair, and development.
Alimirah, Fatouma, Baker, Darren J, Campisi, Judith, Hildesheim, Jeffrey, van Deursen, Jan M   +4 more
core  

Morphofunctional Heterogeneity and Plasticity of Glioblastoma Cells Induced to Senescence by Temozolomide

Aging Cell, Volume 25, Issue 4, April 2026.
Glioblastoma cells induced to senescence by Temozolomide are heterogeneous, with the emergence of two main states, named E‐state and F‐state, which differ in cellular morphometry, survival mechanisms, and sensitivity to autophagy modulators and senolytics. These states are dynamic, with the occurrence of morphofunctional transitions.
Solon Andrades da Rosa, Henrique Quaiato de Oliveira, Laura Boose de Mendonça, Nicole Borgmann de Oliveira, Mariane da Cunha Jaeger, Luiza Cherobini Pereira, Fernanda Dittrich Pinto Oliveira, Debora Santos‐Sousa, Fernanda Saez‐Calazans, Luana Lenz, Melike Lakadamyali, Guido Lenz, Eduardo Cremonese Filippi‐Chiela   +12 more
wiley   +1 more source

The role of apoptosis repressor with a CARD domain (ARC) in the therapeutic resistance of renal cell carcinoma (RCC): the crucial role of ARC in the inhibition of extrinsic and intrinsic apoptotic signalling [PDF]

, 2017
Background: Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One important anti-apoptotic factor that is
Funke, Sarah, Gasis, Marcia, Hanenberg, Helmut, Heikaus, Sebastian, Liverts, Anna, Mahotka, Csaba, Nitsche, Vanessa, Schirmacher, Peter, Toth, Csaba, Wiek, Constanze, Zlachevska, Viktoriya   +10 more
core   +1 more source

Senolytic Treatment Reduces Acute and Chronic Lung Inflammation in an Aged Mouse Model of Influenza

Aging Cell, Volume 25, Issue 4, April 2026.
Removing age‐related senescent cells before influenza infection in aged mice did not reduce viral replication but lessened lung pathology and gut dysbiosis, which contribute to disease severity. Treatment also mitigated long sequelae in lungs. Effects were mostly age‐dependent, implicating pre‐existing senescent cells in disease severity.
Lou Delval, Marybeth Creskey, Clara Valentin, Clément Bordas, Stephano Raviola, Larissa Lipskaia, Séverine Heumel, Lucie Deruyter, Valentin Sencio, Isabelle Wolowczuk, David Bernard, Serge Adnot, Philippe Gosset, Xu Zhang, François Trottein   +14 more
wiley   +1 more source

PMCA2 silencing potentiates MDA-MB-231 breast cancer cell death initiated with the Bcl-2 inhibitor ABT-263 [PDF]

, 2016
PMCA2 overexpression in some breast cancers suggests that this calcium pump isoform may play a role in breast pathophysiology. To investigate PMCA2 as a potential drug target for breast cancer therapy, we assessed the functional consequence of PMCA2 ...
Curry, Merril, Monteith, Gregory R., Roberts-Thomson, Sarah J.   +2 more
core   +1 more source

IAP Antagonists Selectively Eliminate Therapy‐Induced Senescent Cancer Cells via TNFα‐Independent Apoptosis

Cancer Science, Volume 117, Issue 4, Page 1043-1056, April 2026.
Upon chemotherapy, a subset of cancer cells enters a senescent state, referred to as TIS. When IAP antagonists are administered, TIS cells are selectively eliminated through TNFα‐independent apoptosis. TNFα secreted by TIS cancer cells may also act in a paracrine manner to enhance extrinsic apoptosis in neighboring non‐senescent cancer cells.
Hiroaki Ochiiwa, Takeshi Wakasa, Yuki Kataoka, Koji Ando, Eiji Oki, Yoshihiko Maehara, Makoto Iimori, Hiroyuki Kitao   +7 more
wiley   +1 more source

PROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer

Cells
BCL-xL and BCL-2 are validated therapeutic targets in small-cell lung cancer (SCLC). Targeting these proteins with navitoclax (formerly ABT263, a dual BCL-xL/2 inhibitor) induces dose-limiting thrombocytopenia through on-target BCL-xL inhibition in ...
Sajid Khan, Lin Cao, Janet Wiegand, Peiyi Zhang, Maria Zajac-Kaye, Frederic J. Kaye, Guangrong Zheng, Daohong Zhou   +7 more
doaj   +1 more source

Timed degradation of Mcl-1 controls mitotic cell death [PDF]

, 2018
Mitotic arrest can result in cell death through the process of apoptosis. We have shown by live-cell imaging that the ubiquitin-proteasome dependent proteolysis of the apoptotic regulator Mcl-1 under the control of the anaphase-promoting complex or ...
Allan, Lindsey A., Clarke, Paul R., Skowyra, Agnieszka   +2 more
core   +3 more sources