Results 81 to 90 of about 7,693 (199)

Bcl-2 expression predicts sensitivity to chemotherapy in breast cancer: a systematic review and meta-analysis [PDF]

, 2013
BACKGROUND: Numerous studies have yielded inconclusive results regarding the relationship between anti-apoptotic protein Bcl-2 expression and the sensitivity to chemotherapy in the patients with breast cancer.
Chao-Ying Liu, Dong Yang, Lan Yang, Li-Qiang Wang, Min-Bin Chen, Pei-Hua Lu   +5 more
core   +1 more source

Integrative Approaches to Treating Cellular Senescence in Kidney Disease

Advanced Science, Volume 13, Issue 21, 13 April 2026.
ABSTRACT Cellular senescence in the kidney plays a crucial role in the progression of acute kidney injury and chronic kidney disease. Therapeutic approaches targeting senescent cells, such as small molecule senolytic and senomorphic drugs, display efficacy in preclinical models.
Tomoka Misawa, Amruta A, LaTonya J. Hickson, Joy Wolfram   +3 more
wiley   +1 more source

Idasanutlin and navitoclax induce synergistic apoptotic cell death in T-cell acute lymphoblastic leukemia

Leukemia, 2023
AbstractT-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy in which activating mutations in the Notch pathway are thought to contribute to transformation, in part, by activating c-Myc. Increased c-Myc expression induces oncogenic stress that can trigger apoptosis through the MDM2-p53 tumor suppressor pathway.
Kimberly B. Johansson, Megan S. Zimmerman, Iryna V. Dmytrenko, Feng Gao, Daniel C. Link   +4 more
openaire   +3 more sources

Harnessing Tumor Organoids to Revolutionize Immunotherapy Research

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Immunotherapy has emerged as a revolutionary approach to cancer treatment, yet the lack of robust preclinical testing platforms impedes progress in this field. Tumor organoids, three‐dimensional structures derived from patient‐specific samples, differ from conventional models by faithfully recapitulating the histological, genetic, and ...
Zhen Wang, Peipei Yin, Shizhan Cui, Hui Liu, Dan Li, Yang Yu, Baoshan Cao, Xiaojuan Liu   +7 more
wiley   +1 more source

Co-targeting of Bcl-2 and mTOR pathway triggers synergistic apoptosis in BH3 mimetics resistant acute lymphoblastic leukemia [PDF]

, 2015
Several chemo-resistance mechanisms including the Bcl-2 protein family overexpression and constitutive activation of the PI3K/Akt/mTOR signaling have been documented in acute lymphoblastic leukemia (ALL), encouraging targeted approaches to circumvent ...
ALLEGRETTI, MATTEO, Bergamo, P, FOA, Roberto, Iacovelli, S, LICCHETTA, ROBERTO, Martelli, Am, Mccubrey, Ja, Milella, M, MIRABILII, SIMONE, RICCIARDI, Maria Rosaria, Rinaldo, C, TAFURI, Agostino, Zeuner, A   +12 more
core   +1 more source

Adverse Effects of Low Serum HDL‐C Levels on Prognosis and Tumor Immune Microenvironment in Patients With Newly Diagnosed Chronic Lymphocytic Leukemia

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Disorders of lipid metabolism contribute to the occurrence and progression of hematological malignancies, including chronic lymp hocytic leukemia (CLL). The objective of this study was to investigate the association between serum lipid levels and prognosis in patients with CLL.
Weiran Lv, Shutong Liu, Jiangtao Song, Zhijian Liang, Huaze Liao, Qianqian Huang, Ziang Zhu, Zhoupei Mo, Yun Wang, Yang Liang   +9 more
wiley   +1 more source

Multi‐Omics Analysis of TYMS as a Prognostic Biomarker and Therapeutic Target for Lung Adenocarcinoma

Cancer Medicine, Volume 15, Issue 4, April 2026.
ABSTRACT Lung adenocarcinoma (LUAD) is a predominant form of lung cancer with poor prognosis due to early diagnosis challenges and treatment resistance. Thymidylate synthetase (TYMS), a key enzyme in DNA synthesis, has been associated with poor prognosis in multiple cancers, yet its multi‐omics characteristics in LUAD remain systematically ...
Hansen Shi, Peijun Zhang, Jiayi Chen, Hua Li, Xiaohuai Zhang, Biyun zeng, Tiancai Liu, Tao Zeng   +7 more
wiley   +1 more source

Rapid Optimization of Mcl-1 Inhibitors using Stapled Peptide Libraries Including Non-Natural Side Chains [PDF]

, 2018
Alpha helices form a critical part of the binding interface for many protein-protein interactions, and chemically stabilized synthetic helical peptides can be effective inhibitors of such helix-mediated complexes.
Keating, Amy E., Letai, Anthony, Rezaei Araghi, Raheleh, Ryan, Jeremy Adam   +3 more
core   +1 more source

Use of nanoparticles to improve the therapeutic index of navitoclax [PDF]

, 2022
Ovarian cancer is considered a major health problem in women. The chemotherapeutic drugs that are used often are inadequate due to the development of drug resistance. This s related to many causes, and one of them is an evasion of apoptosis. One of the major causes that stand behind this apoptosis escaping is overexpression of anti-apoptotic BCL-2 ...
openaire  

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells

Cell Death and Disease, 2021
Inhibitors of the lipogenic enzyme fatty acid synthase (FASN) have attracted much attention in the last decade as potential targeted cancer therapies. However, little is known about the molecular determinants of cancer cell sensitivity to FASN inhibitors
Barbara Schroeder, Travis Vander Steen, Ingrid Espinoza, Chandra M. Kurapaty Venkatapoorna, Zeng Hu, Fernando Martín Silva, Kevin Regan, Elisabet Cuyàs, X. Wei Meng, Sara Verdura, Aina Arbusà, Paula A. Schneider, Karen S. Flatten, George Kemble, Joan Montero, Scott H. Kaufmann, Javier A. Menendez, Ruth Lupu   +17 more
doaj   +1 more source