Results 61 to 70 of about 7,693 (199)

Dual targeting of MDM2 and BCL2 as a therapeutic strategy in neuroblastoma [PDF]

, 2017
Wild-type p53 tumor suppressor activity in neuroblastoma tumors is hampered by increased MDM2 activity, making selective MDM2 antagonists an attractive therapeutic strategy for this childhood malignancy.
Barbieri, Eveline, Moreno-Smith, Myrthala, Shohet, Jason, Speleman, Franki, Van Goethem, Alan, Van Maerken, Tom, Vandesompele, Jo, Vasudevan, Sanjeev A, Yigit, Nurten   +8 more
core   +3 more sources

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Assessment of ABT-263 activity across a cancer cell line collection leads to a potent combination therapy for small-cell lung cancer [PDF]

, 2014
BH3 mimetics such as ABT-263 induce apoptosis in a subset of cancer models. However, these drugs have shown limited clinical efficacy as single agents in small-cell lung cancer (SCLC) and other solid tumor malignancies, and rational combination ...
Benes, Cyril H., Boisvert, Jessica L., Costa, Carlotta, Dastur, Anahita, Ebi, Hiromichi, Edelman, Elena J., Elmiligy, Sarah, Engelman, Jeffrey A., Faber, Anthony C., Farago, Anna, Gomez-Caraballo, Maria, Ham, Jungoh, Harada, Hisashi, Hata, Aaron N., Hicks, Mark A., Jacks, Tyler E, Jakubik, Charles T., Malstrom, Scott E., Malstrom, Scott E., March, Ryan J., Milano, Randy J., Patel, Neha U., Ramaswamy, Sridhar, Rideout, William M., Rivera, Miguel N., Robbins, Rebecca, Song, Youngchul, Tam, Ah Ting, Wagner, Bethany L., Windle, Brad E., Yeo, Alan T.   +30 more
core   +1 more source

Synthesis of Novel C‐Acyl‐Glycosyl Sulfonamides via Pd‐Catalyzed Carbonylative Coupling

European Journal of Organic Chemistry, EarlyView.
A Pd‐catalyzed carbonylative coupling of 1‐iodo‐glycals with diverse sulfonamides using Mo(CO)6 enables efficient access to C‐acyl‐glycosyl sulfonamides.This robust and versatile strategy delivers novel glycoside derivatives in good to excellent yields, highlighting their potential for drug discovery.
João A. F. Silva, Mônica F. Z. J. Toledo, Flávia Manarin, João H. de Araujo‐Neto, Milene M. Hornink, Hélio A. Stefani   +5 more
wiley   +1 more source

High‐Salt Diet–Induced Endothelial Dysfunction Is Mediated by Cellular Senescence

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background High salt (HS) intake is a known cardiovascular risk factor, yet the mechanisms linking salt intake to endothelial dysfunction remain unclear.
André F. Nascimento, Renata A. M. Luvizotto, Rafael M. Costa, Gustavo F. Pimenta, Ariane Bruder, Thiago Bruder‐Nascimento   +5 more
doaj   +1 more source

In vitro activity of a G-quadruplex-stabilizing small molecule that synergizes with Navitoclax to induce cytotoxicity in acute myeloid leukemia cells

BMC Cancer, 2019
Background Acute Myeloid Leukemia (AML) is a malignancy of myeloid precursor cells that arise from genomic alterations in the expression of key growth regulatory genes causing cells to assume an undifferentiated state and continue to proliferate.
Justin J. Montoya, Megan A. Turnidge, Daniel H. Wai, Apurvi R. Patel, David W. Lee, Vijay Gokhale, Laurence H. Hurley, Robert J. Arceci, Cynthia Wetmore, David O. Azorsa   +9 more
doaj   +1 more source

Pharmacological senolysis reduces doxorubicin-induced cardiotoxicity and improves cardiac function in mice

Pharmacological Research, 2022
Many anticancer agents used in clinics induce premature senescence in healthy tissues generating accelerated aging processes and adverse side-effects in patients.
Araceli Lérida-Viso, Alejandra Estepa- Fernández, Ángela Morellá-Aucejo, Beatriz Lozano-Torres, María Alfonso, Juan F. Blandez, Viviana Bisbal, Pilar Sepúlveda, Alba García-Fernández, Mar Orzáez, Ramón Martínez-Máñez   +10 more
doaj   +1 more source

Real‐world treatment patterns and outcomes in accelerated and blast‐phase myeloproliferative neoplasms: Insights from a large multi‐centre cohort analysis in the United Kingdom

British Journal of Haematology, EarlyView.
Summary This UK‐based retrospective analysis describes real‐world treatment patterns and outcomes in 175 patients with accelerated (AP, n = 69) or blast‐phase (BP, n = 106) ‘Philadelphia‐negative’ myeloproliferative neoplasms (MPN‐AP/BP) diagnosed between 2013 and 2025. Median age at transformation was 71 years.
Alexandros Rampotas, Gabriel Naylor‐Layland, Clare Brown, Ahmad Alabdulkarim, Jennifer Ryan, Frances Wadelin, Samah Alimam, Phyo Wint Wint Tun, Jonathan Lambert, Jennifer O'Sullivan, Andrew J. Wilson, Laith Tafesh, Andrew McGregor, Simone Claudiani, Andrew Innes, Emily Booth, James Leveson, Steve Knapper, Mamta Garg, Mani Dubey, Theodora Vatopoulou, Charlotte Brierley, Wai Ka Natalie Leung, Graham Greenfield, Mary Frances McMullin, Alesia Khan, Kate Milne, Duncan Brian, Anna Godfrey, Claire N. Harrison, Bethan Psaila, Patrick Harrington, Amy Kirkwood, Tim C. P. Somervaille, Donal P. McLornan, on behalf of the UK Blood Cancer Research Network MPN Clinical Study Group   +35 more
wiley   +1 more source

Targeting hexokinase 2 to induce breast cancer cell senescence

British Journal of Pharmacology, EarlyView.
Background and Purpose Hexokinase 2 (HK2) is a key enzyme linked to high tumour cell proliferation. Its inhibitors such as 3‐bromopyruvic acid (3‐BP) induce cancer cell death, highlighting HK2 modulation as potential anti‐cancer treatment. However, standard chemotherapies often cause the emergence of senescent cancer cells, which goes along with cell ...
Helmut Bischof, Katarina Cisarova, Sandra Burgstaller, Mia Schwerer, Markus Absenger‐Novak, Philipp J. Jost, Roland Malli, Wolfgang F. Graier, Robert Lukowski   +8 more
wiley   +1 more source

Cirmtuzumab inhibits Wnt5a-induced Rac1 activation in chronic lymphocytic leukemia treated with ibrutinib. [PDF]

, 2016
Signaling via the B cell receptor (BCR) plays an important role in the pathogenesis and progression of chronic lymphocytic leukemia (CLL). This is underscored by the clinical effectiveness of ibrutinib, an inhibitor of Bruton's tyrosine kinase (BTK) that
Chen, L, Chen, Y, Choi, MY, Cui, B, Kipps, TJ, Rassenti, LZ, Widhopf Ii, GF, Wu, Christina, Yu, J, Zhang, L   +9 more
core   +1 more source