Results 41 to 50 of about 7,693 (199)

Is now the time for molecular driven therapy for diffuse large B-cell lymphoma? [PDF]

, 2017
INTRODUCTION: Recent genetic and molecular discoveries regarding alterations in diffuse large B-cell lymphoma (DLBCL) deeply changed the approach to this lymphoproliferative disorder.
Ansuinelli, Michela, DE ANGELIS, Federico, DI ROCCO, Alice, Foa, Roberto, Martelli, Maurizio   +4 more
core   +1 more source

Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer

Cell Death and Disease, 2021
Conventional chemotherapy is still of great utility in oncology and rationally constructing combinations with it remains a top priority. Drug-induced mitochondrial apoptotic priming, measured by dynamic BH3 profiling (DBP), has been shown in multiple ...
Danielle S. Potter, Ruochen Du, Patrick Bhola, Raphael Bueno, Anthony Letai   +4 more
doaj   +1 more source

The Combination of Radiation with PARP Inhibition Enhances Senescence and Sensitivity to the Senolytic, Navitoclax, in Triple Negative Breast Tumor Cells

Biomedicines, 2023
Despite significant advances in the treatment of triple-negative breast cancer, this disease continues to pose a clinical challenge, with many patients ultimately suffering from relapse.
Abrar Softah, Moureq R. Alotaibi, Ali R. Alhoshani, Tareq Saleh, Khalid Alhazzani, Mashal M. Almutairi, Raed AlRowis, Samiyah Alshehri, Norah A. Albekairy, Hisashi Harada, Rowan Boyd, Eesha Chakraborty, David A. Gewirtz, Homood M. As Sobeai   +13 more
doaj   +1 more source

Clearance of Senescent Cells by BCL_XL-PROTAC: A Novel Approach to Treat COPD? [PDF]

Aging Cell
Cellular senescence plays a significant role in the progression of age‐related diseases like chronic obstructive pulmonary disease (COPD). Our research shows that clearing senescent cells with the senolytic BCLXL‐PROTAC reduces senescence markers in COPD airway cells and promotes lung regeneration, suggesting its potential as a novel COPD therapy ...
Devulder JV, Fenwick PS, Kolosionek E, Al-Sahaf M, Viola P, Lemaire R, Razdan N, Kudo H, Sinadinos A, Odqvist L, Donnelly LE, Barnes PJ.   +11 more
europepmc   +2 more sources

Transient metabolic improvement in obese mice treated with navitoclax or dasatinib/quercetin

Aging, 2020
Senescent cells accumulate with obesity in the white adipose tissue of mice and humans. These senescent cells enhance the pro-inflammatory environment that, with time, contributes to the onset of glucose intolerance and type 2 diabetes. Glucose intolerance in mouse models of obesity has been successfully reversed by the elimination of senescent cells ...
Sierra-Ramirez, Arantzazu, López-Aceituno, José Luis, Costa-Machado, Luis Filipe, Plaza, Adrián, Barradas, Marta, Fernandez-Marcos, Pablo Jose   +5 more
openaire   +2 more sources

Combination with vorinostat overcomes ABT-263 (navitoclax) resistance of small cell lung cancer [PDF]

Cancer Biology & Therapy, 2015
Small cell lung cancer (SCLC) is an aggressive tumor type with high mortality. One promising approach for SCLC treatment would be to utilize agents targeting molecular abnormalities regulating resistance to apoptosis. BH3 mimetic antagonists, such as ABT-737 and its orally available derivative ABT-263 (navitoclax) have been developed to block the ...
Wataru, Nakajima, Kanika, Sharma, Mark A, Hicks, Ngoc, Le, Rikiara, Brown, Geoffrey W, Krystal, Hisashi, Harada   +6 more
openaire   +2 more sources

Chemoinformatic Screening for the Selection of Potential Senolytic Compounds from Natural Products

Biomolecules, 2021
Cellular senescence is a cellular condition that involves significant changes in gene expression and the arrest of cell proliferation. Recently, it has been suggested in experimental models that the elimination of senescent cells with pharmacological ...
Oscar Salvador Barrera-Vázquez, Juan Carlos Gómez-Verjan, Gil Alfonso Magos-Guerrero   +2 more
doaj   +1 more source

Adamantyl-tethered-biphenylic compounds induce apoptosis in cancer cells by targeting Bcl homologs [PDF]

, 2015
Bcl homologs prominently contribute to apoptotic resistance in cancer cells and serve as molecular targets in treatment of various cancers. Herein, we report the synthesis of biphenyl-adamantane derivatives by a ligand free palladium on carbon based ...
Ananda, H., Anusha, S., Baburajeev, C.P., Basappaa, ., Bender, A., Fuchs, J.E., Li, F., Mathai, J., Mohan, C.D., Rangappa, K.S., Rangappa, S., Sethi, G., Shanmugam, M.K.   +12 more
core   +1 more source

Multi-Omics Investigation of Innate Navitoclax Resistance in Triple-Negative Breast Cancer Cells [PDF]

Cancers, 2020
Cancer cells employ various defense mechanisms against drug-induced cell death. Investigating multi-omics landscapes of cancer cells before and after treatment can reveal resistance mechanisms and inform new therapeutic strategies. We assessed the effects of navitoclax, a BCL2 family inhibitor, on the transcriptome, methylome, chromatin structure, and ...
Michal Marczyk, Gauri A. Patwardhan, Jun Zhao, Rihao Qu, Xiaotong Li, Vikram B. Wali, Abhishek K. Gupta, Manoj M. Pillai, Yuval Kluger, Qin Yan, Christos Hatzis, Lajos Pusztai, Vignesh Gunasekharan   +12 more
openaire   +2 more sources

Targeting the differential addiction to anti-apoptotic BCL-2 family for cancer therapy [PDF]

, 2017
BCL-2 family proteins are central regulators of mitochondrial apoptosis and validated anti-cancer targets. Using small cell lung cancer (SCLC) as a model, we demonstrated the presence of differential addiction of cancer cells to anti-apoptotic BCL-2, BCL-
Chen, Hui-Chen, Cheng, Emily H, Dong, Yiyu, Ganesan, Yogesh Tengarai, Han, Song, Hellmann, Matthew D, Hsieh, James J, Inoue-Yamauchi, Akane, Ishizawa, Kota, Jebiwott, Sylvia, Jeng, Paul S, Kim, Kwanghee, Kris, Mark G, Pietanza, Maria C   +13 more
core   +2 more sources