Results 31 to 40 of about 7,693 (199)
Pharmaceutics, 2022 The efficacy of antimitotics is limited by slippage, whereby treated cells arrested in mitosis exit mitosis without cell division and, eventually, escape apoptosis, constituting a serious resistance mechanism to antimitotics.
Bárbara Pinto +5 more
doaj +1 more source
ABT263 (Navitoclax) Treatment in Mice v1
, 2023 This protocol is for treating mice with the senolytic, Navitoclax, by oral gavage.
Andrew Davis, Peter Adams
openaire +1 more source
PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors
Exploration of Targeted Anti-tumor Therapy, 2020 BCL-XL is an anti-apoptotic protein that plays an important role in tumorigenesis, metastasis, and intrinsic or therapy-induced cancer drug resistance.
Peiyi Zhang +5 more
doaj +1 more source
Targeting BCL-2 regulated apoptosis in cancer [PDF]
, 2018 The ability of a cell to undergo mitochondrial apoptosis is governed by pro- and anti-apoptotic members of the BCL-2 protein family. The equilibrium of pro- versus anti-apoptotic BCL-2 proteins ensures appropriate regulation of programmed cell death ...
Campbell, Kirsteen J. +1 more
core +1 more source
Small molecule and peptide inhibitors of the pro-survival protein Mcl-1 [PDF]
, 2016 The ability of protein–protein interactions to regulate cellular processes in both beneficial and detrimental ways has made them obvious drug targets.
Beekman, Andrew, Howell, Lesley
core +1 more source
Maritoclax and Dinaciclib inhibit MCL-1 activity and induce apoptosis in both a MCL-1-dependent and -independent manner [PDF]
, 2015 The anti-apoptotic BCL-2 family proteins are important targets for cancer chemotherapy. Specific and potent inhibitors of the BCL-2 family, such as ABT-263 (navitoclax) and ABT-199, are only effective against some members of the BCL-2 family but do not ...
Amin, Shantu +6 more
core +4 more sources
Nature Communications, 2023 Malignant pleural mesothelioma (MPM) has relatively ineffective first/second-line therapy for advanced disease and only 18% five-year survival for early disease.
Danielle S. Potter +6 more
doaj +1 more source
HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia [PDF]
, 2016 Peer ...
Eldfors, Samuli +16 more
core +1 more source
Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity. [PDF]
, 2020 The accumulation of senescent cells (SnCs) is a causal factor of various age-related diseases as well as some of the side effects of chemotherapy. Pharmacological elimination of SnCs (senolysis) has the potential to be developed into novel therapeutic ...
Budamagunta, Vivekananda +9 more
core +1 more source
Prolonged mitotic arrest induces a caspase-dependent DNA damage response at telomeres that determines cell survival [PDF]
, 2016 A delay in the completion of metaphase induces a stress response that inhibits further cell proliferation or induces apoptosis. This response is thought to protect against genomic instability and is important for the effects of anti-mitotic cancer drugs.
A Orthwein +24 more
core +2 more sources