Results 21 to 30 of about 7,693 (199)
Scientific Reports, 2021 Conventional chemotherapeutic agents are nonselective, often resulting in severe side effects and the development of resistance. Therefore, new molecular-targeted therapies are urgently needed to be integrated into existing treatment regimens.
Katja Tuomainen +13 more
doaj +1 more source
Navitoclax Most Promising BH3 Mimetic for Combination Therapy in Hodgkin Lymphoma
International Journal of Molecular Sciences, 2022 The treatment of young patients with Hodgkin lymphoma (HL) is often successful but a significant proportion of patients suffers from late toxicity. In the current era there are new opportunities for less toxic and more targeted treatment options. In this respect, the anti-apoptotic pathway is an attractive target since Hodgkin tumor cells abundantly ...
Myra Langendonk +5 more
openaire +3 more sources
A motor neuron disease mouse model reveals a non-canonical profile of senescence biomarkers
Disease Models & Mechanisms, 2022 To evaluate senescence mechanisms, including senescence-associated secretory phenotype (SASP), in the motor neuron disease model hSOD1-G93A, we quantified the expression of p16 and p21 and senescence-associated β-galactosidase (SA-β-gal) in nervous ...
Pascual Torres +10 more
doaj +1 more source
Clearance of senescent cells by navitoclax (ABT263) rejuvenates UHMWPE-induced osteolysis
International Immunopharmacology, 2023 Periprosthetic osteolysis is the leading cause of prosthesis failure and subsequent total joint revision. Wear particles produced by prosthetic materials are the main biological factors that cause periprosthetic osteolysis. Reducing the inflammatory response induced by the phagocytosis of wear particles by macrophages, blocking the activation of ...
Weiping Su +3 more
openaire +2 more sources
A versatile method for the identification of senolytic compounds
Cell Stress, 2023 The increased burden of senescent cells is as a well-established hallmark of aging and age-related diseases. This finding sparked significant interest in the identification of molecules capable of selectively eliminating senescent cells, so-called ...
Chiara Annunziata +8 more
doaj +1 more source
The emerging role of cellular senescence in renal diseases [PDF]
, 2020 Cellular senescence represents the state of irreversible cell cycle arrest during cell division. Cellular senescence not only plays a role in diverse biological events such as embryogenesis, tissue regeneration and repair, ageing and tumour occurrence ...
Alpini, Gianfranco +12 more
core +1 more source
Bone marrow senescence and the microenvironment of hematological malignancies [PDF]
, 2020 Senescence is the irreversible arrest of cell proliferation that has now been shown to play an important role in both health and disease. With increasing age senescent cells accumulate throughout the body, including the bone marrow and this has been ...
Bowles, Kristian M. +3 more
core +1 more source
Clearance of systemic hematologic tumors by venetoclax (Abt‐199) and navitoclax [PDF]
Pharmacology Research & Perspectives, 2015 AbstractThe Bcl‐2 family inhibitors venetoclax and navitoclax demonstrated potent antitumor activity in chronic lymphocytic leukemia patients, notably in reducing marrow load and adenopathy. Subsequent trials with venetoclax have been initiated in non‐Hodgkin's lymphoma and multiple myeloma patients.
Ackler, Scott +14 more
openaire +2 more sources
MCL1 inhibitors S63845/MIK665 plus Navitoclax synergistically kill difficult-to-treat melanoma cells [PDF]
Cell Death & Disease, 2020 AbstractCurrent treatment for patients with metastatic melanoma include molecular-targeted therapies and immune checkpoint inhibitors. However, a subset of melanomas are difficult-to-treat. These melanomas include those without the genetic markers for targeted therapy, non-responsive to immunotherapy, and those who have relapsed or exhausted their ...
Nabanita Mukherjee +18 more
openaire +2 more sources
Frontiers in Cell and Developmental Biology, 2020 Senescence is a cellular defense mechanism that helps cells prevent acquired damage, but chronic senescence, as in aging, can contribute to the development of age-related tissue dysfunction and disease.
Anuj K. Sharma +7 more
doaj +1 more source