Results 141 to 150 of about 4,212 (160)
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Characterization of the Interaction of GABARAPL-1 with the LIR Motif of NBR1
Journal of Molecular Biology, 2011Selective autophagy requires the specific segregation of targeted proteins into autophagosomes. The selectivity is mediated by autophagy receptors, such as p62 and NBR1, which can bind to autophagic effector proteins (Atg8 in yeast, MAP1LC3 protein family in mammals) anchored in the membrane of autophagosomes.
Vladimir V Rogov +2 more
exaly +3 more sources
Genome sequence of the Nocardia bacteriophage NBR1
Archives of Virology, 2013We here characterize a novel bacteriophage (NBR1) that is lytic for Nocardia otitidiscaviarum and N. brasiliensis. NBR1 is a member of the family Siphoviridae and appears to have a structurally more complex tail than previously reported Siphoviridae phages.
Steve, Petrovski +2 more
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NBR1-mediated selective chloroplast autophagy is important to plant stress tolerance
Autophagy, 2023Macroautophagy/autophagy is a conserved process in eukaryotes responsible for degrading unwanted or damaged macromolecules and organelles through the lysosome or vacuole for recycling and reutilization. Our previous studies revealed the degradation of chloroplast proteins through a pathway dependent on the ubiquitin proteasome system, known as CHLORAD.
Hui Zhang, Qihua Ling
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Germline mutation in the NBR1 gene involved in autophagy detected in a family with renal tumors
Cancer Genetics, 2021Hereditary Renal Cell Carcinomas (RCC) are caused by mutations in predisposing genes, the major ones including VHL, FLCN, FH and MET. However, many families with inherited RCC have no germline mutation in these genes. Using Whole Exome Sequencing on germline DNA from a family presenting three different histological renal tumors (an angiomyolipoma, a ...
Florine, Adolphe +14 more
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Brca1 expression is regulated by a bidirectional promoter that is shared by the Nbr1 gene in mouse
Gene, 2004The lack of functionally disrupting mutations of BRCA1 in sporadic breast tumours has suggested that other mechanisms, including dysregulation of gene expression, might be important in tumour development. We have analysed the control of expression of murine Brca1 and the adjacent gene, Nbr1, which lie head-to-head and are separated by less than 300 bp.
Whitehouse, C +3 more
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Neuroscience Letters, 2012
Incorporation of ubiquitin and ubiquitin-related proteins including p62 into neuronal intranuclear inclusions (NIIs) has been reported in a variety of neurodegenerative diseases. However, involvement of autophagy-specific proteins (NBR1 and LC3) in NIIs has not been mentioned.
Fumiaki Mori +2 more
exaly +3 more sources
Incorporation of ubiquitin and ubiquitin-related proteins including p62 into neuronal intranuclear inclusions (NIIs) has been reported in a variety of neurodegenerative diseases. However, involvement of autophagy-specific proteins (NBR1 and LC3) in NIIs has not been mentioned.
Fumiaki Mori +2 more
exaly +3 more sources
NBR1 in the regulation of T cell development and differentiation (P1000)
The Journal of Immunology, 2013Abstract NBR1 (neighbor of BRCA1 gene 1) is a newly discovered signaling molecule containing a Phox and Bem1 (PB1) domain. PB1-domains are protein interaction modules. PB1 domain-containing molecules participate in diverse biological processes, which also include p62, Par-6, MEK5a, MEKK3, PKCζ and PKC λ/ι besides NBR1.
Jun-Qi Yang +3 more
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Chloroplast microautophagy: A green role for NBR1
Autophagy, 2023Han Nim Lee +2 more
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Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression
Developmental Cell, 2020Timothy Marsh +2 more
exaly