Results 131 to 140 of about 4,212 (160)

PTK6 drives HNRNPH1 phase separation to activate autophagy and suppress apoptosis in colorectal cancer. [PDF]

Autophagy
Chen B, Liu B, Chen J, Li W, Ma N, Liu J, Fan R, Hu Q, Song H, Xu Y, Jiang T, Song J.   +11 more
europepmc   +1 more source

CUL1-neddylation contributes to K29-linked ubiquitination on p27 for autophagic degradation in sorafenib-resistant liver cancer. [PDF]

Cell Biol Toxicol
Xu H, Zheng S, Zhang Q, Xu Y, Zhang H, Hu T, Zhang X, E J, Li X, Wang R, Liu H, Xie R.   +11 more
europepmc   +1 more source

From homeostasis to pathology, organelle-specific autophagy in skeletal muscle: a PRISMA-ScR scoping review. [PDF]

Front Physiol
Wang C, Liu G, Guo C, Li Q, Wang F, Zhang M.   +5 more
europepmc   +1 more source

Mitophagy in bladder cancer: a double-edged sword in tumor progression and therapy. [PDF]

J Transl Med
Chen Q, Chen T, Gan L, Lu Y, Qian B.
europepmc   +1 more source

Phosphorylation of NBR1 by GSK3 modulates protein aggregation [PDF]

Autophagy, 2014
The autophagy receptor NBR1 (neighbor of BRCA1 gene 1) binds UB/ubiquitin and the autophagosome-conjugated MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3) proteins, thereby ensuring ubiquitinated protein degradation. Numerous neurodegenerative and neuromuscular diseases are associated with inappropriate aggregation of ubiquitinated ...
Anne-Sophie Nicot, Fanny Pilot-Storck, Marco Sandri   +2 more
exaly   +3 more sources

Autophagy suppresses breast cancer metastasis by degrading NBR1 [PDF]

Autophagy, 2020
Macroautophagy/autophagy plays complex, context-dependent roles in cancer. How autophagy governs the emergence of metastatic disease has been incompletely understood. We recently uncovered that genetic autophagy inhibition strongly attenuates primary tumor growth in mammary cancer models, yet paradoxically promotes spontaneous metastasis to the lung ...
Timothy Marsh, Jayanta Debnath
exaly   +3 more sources

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Role of Nbr1 in bone remodeling

Bone, 2009
The growth and differentiation of bone cells is controlled by various factors which can be modulated by heparan sulfates. Here, we investigated the effects of a low-molecular-weight “heparin-like”, an oversulfated exopolysaccharide (OS-EPS) produced by a mesophilic strain found in deep-sea hydrothermal vents, on bone cells in regard to their ...
Marchbank, K. E., Whitehouse, C. A., Solomon, E.   +2 more
openaire   +4 more sources

Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover [PDF]

FEBS Letters, 2009
MINT‐7034220: NBR1 (uniprotkb:Q14596) physically interacts (MI:0218) with ube2o (uniprotkb:Q6ZPJ3) by two hybrid (MI:0018)
Sarah Waters, Ellen Solomon, Mathias Gautel   +2 more
exaly   +4 more sources

Nbr1-regulated autophagy in Lactoferrin-induced osteoblastic differentiation

Bioscience, Biotechnology and Biochemistry, 2020
ABSTRACT The molecular mechanism of autophagy in Lactoferrin (LF) induced osteoblast differentiation is not fully demonstrated. In this study, alkaline phosphatase (ALP) activity, alizarin red S staining and ELISA were used to study N-terminal propeptide of type I procollagen (PINP) expression.
Yang, Zhang, Zi-Nan, Zhang, Na, Li, Li-Jie, Zhao, Ying, Xue, Hao-Jie, Wu, Jian-Ming, Hou   +6 more
exaly   +3 more sources