Results 151 to 160 of about 4,878 (179)

Microautophagy: current understanding of its molecular mechanisms and functions. [PDF]

Autophagy Rep
Sakai Y, Behrends C, Debnath J, Izumi M, Jenny A, Molinari M, Nakamura S, Oku M, Otegui MS, Santambrogio L, Shen HM, Taguchi T, Thumm M, Ushimaru T, Xie Z, Cuervo AM, Reggiori F.   +16 more
europepmc   +1 more source

Plant-specific mitochondrial fission machinery connects mitochondrial dynamics and mitophagosome formation for piecemeal mitophagy. [PDF]

Proc Natl Acad Sci U S A
Ma J, Li C, Ren K, Zhang K, Feng L, Law KC, Chung KK, Bing Y, Gao C, Kang BH, Zhuang X.   +10 more
europepmc   +1 more source

TAX1BP1 recruitment reactivates autophagy of Tau aggregates through ULK1 and TBK1

Bauer B, Schuschnig M, Martens S.
europepmc   +1 more source

Phosphorylation of NBR1 by GSK3 modulates protein aggregation [PDF]

Autophagy, 2014
The autophagy receptor NBR1 (neighbor of BRCA1 gene 1) binds UB/ubiquitin and the autophagosome-conjugated MAP1LC3/LC3 (microtubule-associated protein 1 light chain 3) proteins, thereby ensuring ubiquitinated protein degradation.
Laurent Schaeffer, Fanny Pilot-Storck, Marco Sandri   +2 more
exaly   +7 more sources

Interactions with LC3 and polyubiquitin chains link nbr1 to autophagic protein turnover [PDF]

FEBS Letters, 2009
Nbr1, a ubiquitous kinase scaffold protein, contains a PB1, and a ubiquitin-associated (UBA) domain. We show here that the nbr1 UBA domain binds to lysine-48 and -63 linked polyubiquitin-B chains.
Mathias Gautel
exaly   +6 more sources

Autophagy suppresses breast cancer metastasis by degrading NBR1 [PDF]

Autophagy, 2020
Macroautophagy/autophagy plays complex, context-dependent roles in cancer. How autophagy governs the emergence of metastatic disease has been incompletely understood. We recently uncovered that genetic autophagy inhibition strongly attenuates primary tumor growth in mammary cancer models, yet paradoxically promotes spontaneous metastasis to the lung ...
Jayanta Debnath, Timothy Marsh
exaly   +3 more sources

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Role of Nbr1 in bone remodeling

Bone, 2009
The growth and differentiation of bone cells is controlled by various factors which can be modulated by heparan sulfates. Here, we investigated the effects of a low-molecular-weight “heparin-like”, an oversulfated exopolysaccharide (OS-EPS) produced by a mesophilic strain found in deep-sea hydrothermal vents, on bone cells in regard to their ...
Whitehouse, C. A., Waters, S., Grigoriadis, A. E., Marchbank, K., McGowan, N., Skerry, T., Sharpe, P. T., Solomon, E.   +7 more
openaire   +4 more sources

Characterization of the Interaction of GABARAPL-1 with the LIR Motif of NBR1

Journal of Molecular Biology, 2011
Selective autophagy requires the specific segregation of targeted proteins into autophagosomes. The selectivity is mediated by autophagy receptors, such as p62 and NBR1, which can bind to autophagic effector proteins (Atg8 in yeast, MAP1LC3 protein family in mammals) anchored in the membrane of autophagosomes.
Volker Dotsch, Frank Lohr, Ivan Dikić   +2 more
exaly   +3 more sources

Genome sequence of the Nocardia bacteriophage NBR1

Archives of Virology, 2013
We here characterize a novel bacteriophage (NBR1) that is lytic for Nocardia otitidiscaviarum and N. brasiliensis. NBR1 is a member of the family Siphoviridae and appears to have a structurally more complex tail than previously reported Siphoviridae phages.
Steve, Petrovski, Robert J, Seviour, Daniel, Tillett   +2 more
openaire   +2 more sources