Results 161 to 170 of about 4,878 (179)

Nbr1-regulated autophagy in Lactoferrin-induced osteoblastic differentiation

Bioscience, Biotechnology and Biochemistry, 2020
ABSTRACT The molecular mechanism of autophagy in Lactoferrin (LF) induced osteoblast differentiation is not fully demonstrated. In this study, alkaline phosphatase (ALP) activity, alizarin red S staining and ELISA were used to study N-terminal propeptide of type I procollagen (PINP) expression.
Yang, Zhang, Zi-Nan, Zhang, Na, Li, Li-Jie, Zhao, Ying, Xue, Hao-Jie, Wu, Jian-Ming, Hou   +6 more
exaly   +3 more sources

Autophagic Degradation of NBR1 Restricts Metastatic Outgrowth during Mammary Tumor Progression [PDF]

Developmental Cell, 2020
Although autophagy is being pursued as a therapeutic target in clinical oncology trials, its effects on metastasis, the principal cause of cancer mortality, remain unclear. Here, we utilize mammary cancer models to temporally delete essential autophagy regulators during carcinoma progression.
Eliah Shamir, Andrew Leidal, Zena Werb   +2 more
exaly   +5 more sources

Opposing regulation of the STING pathway in hepatic stellate cells by NBR1 and p62 determines the progression of hepatocellular carcinoma

Molecular Cell
Hepatocellular carcinoma (HCC) emerges from chronic inflammation to which activation of hepatic stellate cells (HSCs) contributes by shaping a pro-tumorigenic microenvironment.
Jorge Moscat, Tania Cid-Díaz, Anxo Martínez-Ordoñez   +2 more
exaly   +2 more sources

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NBR1-mediated selective chloroplast autophagy is important to plant stress tolerance

Autophagy, 2023
Macroautophagy/autophagy is a conserved process in eukaryotes responsible for degrading unwanted or damaged macromolecules and organelles through the lysosome or vacuole for recycling and reutilization. Our previous studies revealed the degradation of chloroplast proteins through a pathway dependent on the ubiquitin proteasome system, known as CHLORAD.
Hui Zhang, Qihua Ling
openaire   +2 more sources

Cleavage of the selective autophagy receptor NBR1 by the PDCoV main protease NSP5 impairs autophagic degradation of the viral envelope protein

Autophagy
Porcine deltacoronavirus (PDCoV) is an emerging enteropathogenic coronavirus that causes severe diarrhea in neonatal piglets worldwide and presents a significant public health threat due to its potential for cross-species transmission.
Rui Luo, Sizhu Suolang
exaly   +2 more sources

Autophagy-related proteins (p62, NBR1 and LC3) in intranuclear inclusions in neurodegenerative diseases

Neuroscience Letters, 2012
Incorporation of ubiquitin and ubiquitin-related proteins including p62 into neuronal intranuclear inclusions (NIIs) has been reported in a variety of neurodegenerative diseases. However, involvement of autophagy-specific proteins (NBR1 and LC3) in NIIs has not been mentioned.
Koichi Wakabayashi, Yasuko Toyoshima, Kunikazu Tanji   +2 more
exaly   +3 more sources

NBR1 in the regulation of T cell development and differentiation (P1000)

The Journal of Immunology, 2013
Abstract NBR1 (neighbor of BRCA1 gene 1) is a newly discovered signaling molecule containing a Phox and Bem1 (PB1) domain. PB1-domains are protein interaction modules. PB1 domain-containing molecules participate in diverse biological processes, which also include p62, Par-6, MEK5a, MEKK3, PKCζ and PKC λ/ι besides NBR1.
Jun-Qi Yang, Hongzhu Liu, Maria Diaz-Meco, Jorge Moscat   +3 more
openaire   +1 more source

Brca1 expression is regulated by a bidirectional promoter that is shared by the Nbr1 gene in mouse

Gene, 2004
The lack of functionally disrupting mutations of BRCA1 in sporadic breast tumours has suggested that other mechanisms, including dysregulation of gene expression, might be important in tumour development. We have analysed the control of expression of murine Brca1 and the adjacent gene, Nbr1, which lie head-to-head and are separated by less than 300 bp.
Whitehouse, C, Chambers, J, Catteau, A, Solomon, E   +3 more
openaire   +3 more sources

Chloroplast microautophagy: A green role for NBR1

Autophagy, 2023
Han Nim Lee, Sarika K. Marathe, Marisa S. Otegui   +2 more
openaire   +2 more sources

Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes

Gene, 2001
Mouse and human Brca1/BRCA1 and Nbr1/NBR2 genes lie head-to-head, being transcribed from the opposite strands. The normal function of Brca1 is associated with DNA damage-related responses and the maintenance of genome integrity. Mutations of this gene are major risk factors for developing breast and ovarian cancers.
S, Dimitrov, M, Brennerova, J, Forejt
openaire   +2 more sources