Results 11 to 20 of about 35,363 (287)
A Methodology to Design Static NCL Libraries
Journal of Low Power Electronics and Applications, 2022 The Null Convention Logic (NCL) based asynchronous design technique has interested researchers because this technique had overcome disadvantages of the synchronous technique, such as noise, glitches, clock skew and power.
Toi Le Thanh +2 more
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Characterization of the canine
BMC Genetics, 2006 Background The neuronal ceroid lipofuscinoses (NCL) are a heterogenous group of inherited progressive neurodegenerative diseases in different mammalian species. Tibetan Terrier and Polish Owczarek Nizinny (PON) dogs show rare late-onset NCL variants with
Distl Ottmar +2 more
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Bridging NCL research gaps [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2015 The neuronal ceroid lipofuscinoses, collectively called NCLs, are rare and fatal lysosomal storage diseases that mainly affect children. Due to the fact that NCLs are both rare and heterogeneous (mutations in thirteen different genes) significant gaps exist in both preclinical and clinical research.
Stehr, Frank, van der Putten, Herman
openaire +3 more sources
Future perspectives: Moving towards NCL treatments [PDF]
Biochimica et Biophysica Acta, 2015 Clinicians, basic researchers, representatives from pharma and families from around the world met in Cordoba, Argentina in October, 2014 to discuss recent research progress at the 14th International Congress on Neuronal Ceroid Lipofuscinoses (NCLs ...
S. Cotman, S. Mole, R. Kohan
semanticscholar +2 more sources
Multi-Technique Integration Identifies O-GlcNAc Transferase in Fibroblast-Like Synoviocytes as a Therapeutic Target for Rheumatoid Arthritis. [PDF]
Adv Sci (Weinh)AI‑guided single‑cell transcriptomics identifies OGT as a key regulator enriched in rheumatoid arthritis fibroblast‑like synoviocytes (RA‐FLSs). Inflammatory stimuli activate the OGT–SAP130 axis, which modulates the H3K27ac/H3K27me3 balance and epigenetically silences BTG2, promoting aggressive transformation of RA‑FLSs.
Xie D +14 more
europepmc +2 more sources
A Cascaded DNA Nanocircuit for Multi-Signal-Responsive Precision siRNA Delivery in Cancer Therapy. [PDF]
Adv Sci (Weinh)A cascaded dual‐AND logic DNA nanocircuit is engineered to respond to three tumor‐specific signals in a sequential manner: extracellular acidic pH, membrane‐overexpressed nucleolin (NCL), and intracellular glutathione (GSH). This programmable system selectively releases siPARP1 in glioblastoma (GBM), effectively silencing PARP1 and reversing TMZ ...
Zhao Y +14 more
europepmc +2 more sources
Effect of Suction on Volumetric Yielding Behavior under Different Initial Conditions for Fine-Grained Soils [PDF]
Engineering and Technology Journal, 2013 The unsaturated soils are difficult to consider within the framework of classical (saturated) soil mechanics. In general, the unsaturated soil is stiffer than the saturated one (hardening), so the location and slope of normal consolidated line (NCL) or ...
Yasir Al-Badran, Tom Schanz
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Investigation of Crack in Beam Structure using an Adaptive-Genetic Algorithm (AGA)
U.Porto Journal of Engineering, 2022 Fault detection and continuous condition monitoring in structural and machine elements are very sensitive topics and gaining significant value as a current research area. Due to the continuous loading and unloading of these elements, fatigue occurs.
SASMITA SAHU, SHAKTI JENA
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Molecular Biomedicine, 2021 Alzheimer’s disease is a progressive neurodegenerative disease characterized by the presence of amyloid-β plaques in the extracellular environment and aggregates of Tau protein that forms neurofibrillary tangles (NFTs) in neuronal cells. Along with these
Smita Eknath Desale +2 more
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Correlations between structure, microstructure, density and dielectric properties of the lead-free ferroelectrics Bi0.5(Na,K)0.5TiO3 [PDF]
Journal of Advanced Dielectrics, 2015 Solid solutions of the lead-free ferroelectric oxides Bi0.5Na0.5TiO3 (BNT) and Bi0.5K0.5TiO3 (BKT), represented as (1−x)BNT–xBKT, are studied for very close compositions in the range 0≤x≤0.36 to understand the correlation between the structure and the ...
K. Anjali, T. G. Ajithkumar, P. A. Joy
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