Results 171 to 180 of about 27,017 (217)
Carbapenem resistance mediated by <i>bla</i><sub>NDM-13</sub> in a highly drug-resistant <i>Salmonella</i> Stanley ST29 strain in China. [PDF]
Microbiol SpectrZhou J +8 more
europepmc +1 more source
Functional dynamics of water in New Delhi metallo-β-lactamase catalysis. [PDF]
Protein SciKandhan P, Xiong C, Palzkill T, Tao P.
europepmc +1 more source
The emerging NDM carbapenemases
Trends in Microbiology, 2011 Carbapenems were the last β-lactams retaining near-universal anti-Gram-negative activity, but carbapenemases are spreading, conferring resistance. New Delhi metallo-β-lactamase (NDM) enzymes are the latest carbapenemases to be recognized and since 2008 have been reported worldwide, mostly in bacteria from patients epidemiologically linked to the Indian
Nordmann, Patrice +3 more
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International Journal of Antimicrobial Agents, 2014
The growing prevalence of carbapenem resistance in Enterobacteriaceae worldwide is a major concern. New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance has been identified in Enterobacteriaceae from numerous countries including those of the Indian subcontinent. Currently, seven NDM β-lactamase variants (NDM-1 to -7) have been identified.
Bruno Gonzalez Zorn +2 more
exaly +3 more sources
The growing prevalence of carbapenem resistance in Enterobacteriaceae worldwide is a major concern. New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance has been identified in Enterobacteriaceae from numerous countries including those of the Indian subcontinent. Currently, seven NDM β-lactamase variants (NDM-1 to -7) have been identified.
Bruno Gonzalez Zorn +2 more
exaly +3 more sources
Simplified captopril analogues as NDM-1 inhibitors
Bioorganic and Medicinal Chemistry Letters, 2014Captopril is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 value of 7.9μM. It is composed of two units: a 3-mercapto-2-methylpropanoyl fragment and a proline residue. In this study, we synthesized simple amide derivatives of 3-mercapto-2-methylpropanoic acid, and then tested them as NDM-1 inhibitors in order to identify the ...
Quan Zhang, Yue Chen, Zheng Yin
exaly +3 more sources
The spread and acquisition of NDM-1: a multifactorial problem
Expert Review of Anti-infective Therapy, 2013 bla NDM is a major mechanism of resistance of Gram-negative bacteria to β-lactam antibiotics including the carbapenems. bla NDM has been acquired by a large range of Gram-negative bacilli, especially by the Enterobacteriaceae and Acinetobacter spp. The combination of human factors (suboptimal antibiotic stewardship and infection control, movement of ...
Wailan, Alexander M., Paterson, David L.
openaire +6 more sources
The Lancet Infectious Diseases, 2012
The dissemination of members of the Enterobacteriaceae family with extended spectrum beta-lactamases (ESBLs) and metallo-beta-lactamases (MBLs) has become a global concern. ESBLs and MBLs have been reported in humans, domestic animals, wildlife and the environment, and their isolation frequencies are increasing rapidly worldwide. Most studies have been
Badrul, Hasan +4 more
+7 more sources
The dissemination of members of the Enterobacteriaceae family with extended spectrum beta-lactamases (ESBLs) and metallo-beta-lactamases (MBLs) has become a global concern. ESBLs and MBLs have been reported in humans, domestic animals, wildlife and the environment, and their isolation frequencies are increasing rapidly worldwide. Most studies have been
Badrul, Hasan +4 more
+7 more sources
The directed evolution of NDM-1
Antimicrobial Agents and Chemotherapy, 2023ABSTRACT β-Lactam antibiotics are among the most frequently prescribed therapeutic agents. A common mechanism of resistance toward β-lactam antibiotics is the production of β-lactamases. These enzymes are capable of hydrolyzing the β-lactam bond, rendering the drug inactive.
Caitlyn A. Thomas +8 more
openaire +2 more sources
International Journal of Environmental Research and Public Health, 2020 NDM-1-positive Enterobacteriaceae have caused serious clinical infections, with high mortality rates. Carbapenem was the ultimate expectation for the treatment of such infections in clinical practice.
Xuming Deng, Jianfeng Wang
exaly +2 more sources