Results 181 to 190 of about 24,350 (217)
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The Lancet Infectious Diseases, 2012
The dissemination of members of the Enterobacteriaceae family with extended spectrum beta-lactamases (ESBLs) and metallo-beta-lactamases (MBLs) has become a global concern. ESBLs and MBLs have been reported in humans, domestic animals, wildlife and the environment, and their isolation frequencies are increasing rapidly worldwide. Most studies have been
Badrul, Hasan +4 more
+7 more sources
The dissemination of members of the Enterobacteriaceae family with extended spectrum beta-lactamases (ESBLs) and metallo-beta-lactamases (MBLs) has become a global concern. ESBLs and MBLs have been reported in humans, domestic animals, wildlife and the environment, and their isolation frequencies are increasing rapidly worldwide. Most studies have been
Badrul, Hasan +4 more
+7 more sources
International Journal of Antimicrobial Agents, 2014
The growing prevalence of carbapenem resistance in Enterobacteriaceae worldwide is a major concern. New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance has been identified in Enterobacteriaceae from numerous countries including those of the Indian subcontinent. Currently, seven NDM β-lactamase variants (NDM-1 to -7) have been identified.
Kashi Nath Prasad, Aparna Tripathi
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The growing prevalence of carbapenem resistance in Enterobacteriaceae worldwide is a major concern. New Delhi metallo-β-lactamase (NDM)-mediated carbapenem resistance has been identified in Enterobacteriaceae from numerous countries including those of the Indian subcontinent. Currently, seven NDM β-lactamase variants (NDM-1 to -7) have been identified.
Kashi Nath Prasad, Aparna Tripathi
exaly +3 more sources
The directed evolution of NDM-1
Antimicrobial Agents and Chemotherapy, 2023ABSTRACT β-Lactam antibiotics are among the most frequently prescribed therapeutic agents. A common mechanism of resistance toward β-lactam antibiotics is the production of β-lactamases. These enzymes are capable of hydrolyzing the β-lactam bond, rendering the drug inactive.
Caitlyn A. Thomas +8 more
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Clinical Laboratory, 2021
The emergence of multidrug-resistant bacteria has become a serious healthcare problem worldwide.In this study, 192 clinical specimens collected from a tertiary hospital in Al Jouf, Saudi Arabia were processed in order to isolate gram-negative bacteria.
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The emergence of multidrug-resistant bacteria has become a serious healthcare problem worldwide.In this study, 192 clinical specimens collected from a tertiary hospital in Al Jouf, Saudi Arabia were processed in order to isolate gram-negative bacteria.
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Recent research and development of NDM-1 inhibitors
European Journal of Medicinal Chemistry, 2021Bacteria carrying New Delhi metallo-β-lactamase-1 (New Delhi metallo-β-lactamase, NDM-1) resistance gene is a new type of "superbug", which can hydrolyze almost all β-lactam antibiotics, rapidly spread among the same species and even spread among different species. NDM-1 belongs to the class B1 broad-spectrum enzyme of β-lactamase.
Ting, Wang +5 more
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Balkan NDM-1: escape or transplant?
The Lancet Infectious Diseases, 2011164 www.thelancet.com/infection Vol 11 March 2011 4 Sadetzki S, Chetrit A, Lubina A, et al. Risk of thyroid cancer after childhood exposure to ionizing radiation for tinea capitis. J Clin Endocrinol Metab 2006; 91: 4798–04. 5 Boaventura P, Bastos J, Pereira D, et al.
Livermore, David M. +3 more
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Dissemination of NDM-producing bacteria in Southern Brazil
Diagnostic Microbiology and Infectious Disease, 2023The dissemination of NDM-1 carbapenemases (New Delhi Metallo-β-lactamase) is a global public health problem, mainly in developing countries. The aim of this study was to characterize the spread of NDM-producing bacteria in the Southern Brazilian states analyzing epidemiological, molecular, and antimicrobial susceptibility aspects.A total of 10,684 ...
Lavinia N.V.S. Arend +11 more
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The Dissemination of NDM-1 in Acinetobacter baumannii Strains
Current Microbiology, 2022Acinetobacter baumannii is a common pathogen in hospitals and usually causes bacteremia, pneumonia, meningitis, peritonitis and other diseases. Isolates carried NDM-1 gene can make several antibiotics such as carbapenems and other beta-lactams ineffective. Nowadays, the number of A.
Na, Liu +4 more
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NDM-1 — A Cause for Worldwide Concern
New England Journal of Medicine, 2010NDM-1 (New Delhi metallo-beta-lactamase 1), a genetic element encoding multiple-resistance genes, has been found in various Enterobacteriaceae, rendering them resistant to nearly all antimicrobial agents. Success in combating antibiotic-resistant superbugs has been limited.
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Simplified captopril analogues as NDM-1 inhibitors
Bioorganic and Medicinal Chemistry Letters, 2014Captopril is a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 value of 7.9μM. It is composed of two units: a 3-mercapto-2-methylpropanoyl fragment and a proline residue. In this study, we synthesized simple amide derivatives of 3-mercapto-2-methylpropanoic acid, and then tested them as NDM-1 inhibitors in order to identify the ...
Taiyi Wang, Cheng Yang, Quan Zhang
exaly +3 more sources