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Near Infrared Photoimmunotherapy for Cancer
Conference on Lasers and Electro-Optics, 2019Near infrared photoimmunotherapy (NIR-PIT) is a molecularly-targeted cancer photo-therapy based on antibody-photoabsorber (IR700) conjugates. By crashing cancer cells combined with innate and/or adjuvant immune-activation, NIR-PIT activates anti-cancer immunity resulted in curing local and metastatic cancers.
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Near-infrared photoimmunotherapy: basics and clinical application
Japanese Journal of Clinical OncologyAbstract Use of antibody–drug conjugates (ADCs) is rapidly increasing in the field of oncology. While ADCs exhibit strong and cell-selective cytotoxicity, they do not show spatial selectivity. Near-infrared photoimmunotherapy (NIR-PIT, Alluminox™) utilizes photoactivatable ADCs, that is, antibody–photoabsorber conjugates (APCs).
Ryuhei Okada, Takahiro Asakage
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2022
Near-infrared photoimmunotherapy (NIR-PIT) is a cell-specific cancer therapy in which antibody-photoabsorber conjugates (APCs) are activated by NIR light to induce rapid immunogenic cell death with minimal off-target effects. In preclinical settings, bioluminescence imaging (BLI) is useful to quantitatively assess the efficacy of NIR-PIT for both in ...
Ryuhei, Okada +3 more
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Near-infrared photoimmunotherapy (NIR-PIT) is a cell-specific cancer therapy in which antibody-photoabsorber conjugates (APCs) are activated by NIR light to induce rapid immunogenic cell death with minimal off-target effects. In preclinical settings, bioluminescence imaging (BLI) is useful to quantitatively assess the efficacy of NIR-PIT for both in ...
Ryuhei, Okada +3 more
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Near-infrared photoimmunotherapy for salivary duct carcinoma
Auris Nasus LarynxIn Japan, near-infrared photoimmunotherapy (NIR-PIT) was introduced in 2021 as a treatment option for unresectable recurrent head and neck cancer. The treatment targets the epidermal growth factor receptor (EGFR), which is overexpressed in 80-90 % of head and neck squamous cell carcinoma (HNSCC).
Takuma Makino +5 more
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Abstract 4118: Near infrared photoimmunotherapy for lung metastases
Cancer Research, 2015Abstract Introduction and Purpose Lung metastases are a leading cause of cancer related deaths. Current therapies include surgery, chemotherapy and radiotherapy but cause considerable side effects in the remaining normal lung, chest wall and heart.
Kazuhide Sato +3 more
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Synthesis and biological evaluation of EGFR binding peptides for near-infrared photoimmunotherapy
Bioorganic & Medicinal ChemistryNear-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment that involves photoimmunotherapy drug injection and NIR light exposure. In NIR-PIT, antibodies are commonly used as target-directed molecules carrying IRDye700DX (IR700). However, antibodies have disadvantages, such as high cost, complex development strategies, and poor tumor ...
Takuya Otani +3 more
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