Results 121 to 130 of about 60,497 (319)

Necroptosis, necrostatins and tissue injury [PDF]

Journal of Cellular and Molecular Medicine, 2011
Cell death is an integral part of the life of an organism being necessary for the maintenance of organs and tissues. If, however, cell death is allowed to proceed unrestricted, tissue damage and degenerative disease may ensue. Until recently, three morphologically distinct types of cell death were recognized, apoptosis (type I), autophagy (type II) and
Smith, Christopher CT, Yellon, Derek M
openaire   +2 more sources

Homoisoflavanone Delays Colorectal Cancer Progression via DNA Damage‐Induced Mitochondrial Apoptosis and Parthanatos‐Like Cell Death

Advanced Science, EarlyView.
Homoisoflavanone (HIF), a bioactive compound isolated from Polygonatum kingianum, selectively suppresses colorectal cancer progression by inducing DNA damage‐mediated mitochondrial apoptosis and parthanatos‐like cell death. HIF triggers mitochondrial dysfunction, including depolarized membrane potential, elevated ROS, and ATP depletion, while impairing
Hongjie Fan, Huzi Zhao, Pei Zhang, Pengfei Yu, Yunfei Ji, Gang Chen, Hongli Jin, Yanfang Liu, Jin Liu, Zhe‐Sheng Chen, Aiping Lyu, Xinmiao Liang, Yang Chen   +12 more
wiley   +1 more source

Role of necroptosis and immune infiltration in essential thrombocytosis

Hereditas
Background Necroptosis, a recently identified form of programmed cell death involved in the pathogenesis of a variety of tumor and non-tumor diseases. Nevertheless, the function of necroptosis in essential thrombocytosis (ET) remains unclear, which is a ...
Guangming Li, Ying Guo, Yuanyuan Zhang
doaj   +1 more source

Sestrin2 maintains hepatic immune homeostasis and redox balance partially via inhibiting RIPK3-mediated necroptosis in metabolic dysfunction-associated steatohepatitis

Molecular Metabolism
Background & aims: Necroptosis, a novel type of programmed cell death, is intricately associated with inflammatory response. Currently, most studies focus on the activation of necroptosis, while the mechanisms underlying the negative regulation of ...
Jian-Bin Zhang, Qian-Ren Zhang, Qian Jin, Jing Yang, Shuang-Zhe Lin, Jian-Gao Fan   +5 more
doaj   +1 more source

Necroptosis is associated with Rab27‐independent expulsion of extracellular vesicles containing RIPK3 and MLKL

Journal of Extracellular Vesicles, 2022
Extracellular vesicle (EV) secretion is an important mechanism used by cells to release biomolecules. A common necroptosis effector—mixed lineage kinase domain like (MLKL)—was recently found to participate in the biogenesis of small and large EVs ...
Kartik Gupta, Kyle A. Brown, Marvin L. Hsieh, Brandon M. Hoover, Jianxin Wang, Mitri K. Khoury, Vijaya Satish Sekhar Pilli, Reagan S. H. Beyer, Nihal R. Voruganti, Sahil Chaudhary, David S. Roberts, Regina M. Murphy, Seungpyo Hong, Ying Ge, Bo Liu   +14 more
doaj   +1 more source

Analysis of necroptosis-related prognostic genes and immune infiltration in idiopathic pulmonary fibrosis

Frontiers in Immunology, 2023
BackgroundIPF is an undetermined, progressive lung disease. Necroptosis is a type of programmed apoptosis, which involved in the pathogenesis of lung diseases like COPD and ARDS. However, necroptosis in IPF have not been adequately studied.
Hongzuo Chen, Zhenkun Xia, Bei Qing, Wei Wang, Linguo Gu, Ying Chen, Juan Wang, Yunchang Yuan   +7 more
doaj   +1 more source

Measurement and models accounting for cell death capture hidden variation in compound response. [PDF]

, 2020
Cancer cell sensitivity or resistance is almost universally quantified through a direct or surrogate measure of cell number. However, compound responses can occur through many distinct phenotypic outcomes, including changes in cell growth, apoptosis, and
Bae, Song Yi, Guan, Ning, Meyer, Aaron S, Taylor, Scott D, Warner, Katrina, Yan, Rui   +5 more
core   +1 more source

ZBP1 causes inflammation by inducing RIPK3-mediated necroptosis and RIPK1 kinase activity-independent apoptosis

Cell Death and Differentiation
Z-DNA binding protein 1 (ZBP1) has important functions in anti-viral immunity and in the regulation of inflammatory responses. ZBP1 induces necroptosis by directly engaging and activating RIPK3, however, the mechanisms by which ZBP1 induces inflammation ...
L. Koerner, Laurens Wachsmuth, S. Kumari, Robin Schwarzer, Theresa Wagner, Huipeng Jiao, M. Pasparakis   +6 more
semanticscholar   +1 more source

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

Frontiers in Cellular and Infection Microbiology, 2019
Cell death is central to development, organismal homeostasis, and immune responses. The cell death field has experienced tremendous progress by delineating the molecular programs specific to each of the apoptotic and inflammatory cell death pathways ...
R. Malireddi, S. Kesavardhana, T. Kanneganti   +2 more
semanticscholar   +1 more source

Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies

Neural Regeneration Research, 2022
Some scholars have recently developed the concept of PANoptosis in the study of infectious diseases where pyroptosis, apoptosis and necroptosis act in consort in a multimeric protein complex, PANoptosome.
Weitao Yan, Yan-di Yang, Xi-min Hu, Wen-Ya Ning, Lyu-Shuang Liao, Shuang Lu, Wen-Juan Zhao, Qi Zhang, Kun Xiong   +8 more
semanticscholar   +1 more source