Results 191 to 200 of about 60,497 (319)
Journal of Intelligent Medicine, EarlyView.Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran +5 more
wiley +1 more source
Liver Stiffness Characterization of OGTLKO Mouse Model of Progressive Liver Fibrosis
Journal of Ultrasound in Medicine, EarlyView.Objectives O‐GlcNAcylation plays a key regulatory role in hepatic physiology, and its disruption leads to fibrosis in liver‐specific OGT knockout mice (OGTLKO), making this model valuable for studying advanced metabolic dysfunction‐associated steatohepatitis (MASH).
Gilles Renault +9 more
wiley +1 more source
Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway. [PDF]
Adv Sci (Weinh)A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Shi Q +8 more
europepmc +2 more sources
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Preeclampsia (PE) is an obstetric disease that is characterized by reduced migration and invasion of placental trophoblast cells. Here, the effects of the E3 ubiquitin ligase UBE3A on the migration and invasion of trophoblast cells were evaluated.
Xiu‐Jun Li +5 more
wiley +1 more source
LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL
Cell Death and DiseasePlasma membrane accumulation of phosphorylated mixed lineage kinase domain-like (MLKL) is a hallmark of necroptosis, leading to membrane rupture and inflammatory cell death.
Nadine Weinelt +14 more
doaj +1 more source
Necroptosis Mediates Cigarette Smoke-Induced Inflammatory Responses in Macrophages
International Journal of COPD, 2020 Yong Wang, Xiao-Ke Wang, Pei-Pei Wu, Yi Wang, Liang-Yu Ren, Ai-Hui Xu Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Anhui Medical University, Hefei 230022, People’s Republic of ChinaCorrespondence: Ai-Hui ...
Wang Y +5 more
doaj
The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT Radiotherapy effectively eradicates tumor cells but can also trigger pyroptotic damage in vascular endothelial cells. This study investigates the role of interferon regulatory factor 1 (IRF1) in radiation‐induced endothelial injury, aiming to provide mechanistic insights for optimizing radiotherapy.
Chen Li +4 more
wiley +1 more source
Med Research, EarlyView.ABSTRACT Alveolar fibroblasts play a key role in regulation of lung inflammation. Pseudomonas aeruginosa (PAO) is one of the most common pathogens causing lung injury, and the role of PAO‐infected alveolar fibroblasts in such a condition remains unclear.
Yue Zhou +6 more
wiley +1 more source
Necroptosis of Glycolytic Dendritic Cells Enhances Activation of Gamma Delta T Cells [PDF]
, 2016 Gamma delta (gd) T lymphocytes are a poorly understood class of immune cells that accumulate at sites of inflammation due to infection or autoimmunity. Part of the mystery of this T cell subset derives from lack of knowledge of ligands that bind to the T
Bashant, Kathleen R
core +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Respiratory syncytial virus (RSV) is a common virus that causes respiratory infections, posing a serious threat, particularly to infants, the elderly, and individuals with compromised immune systems. As the leading cause of lower respiratory tract infections (LRTIs) in infants, RSV is responsible for millions of cases worldwide each year.
Jie Shi +6 more
wiley +1 more source