Results 191 to 200 of about 51,913 (289)

Necroptosis in Nonalcoholic Steatohepatitis

Cellular and Molecular Gastroenterology and Hepatology, 2015
Jérémie Gautheron, PhD, Mihael Vucur, PhD, Tom Luedde MD,, PhD   +2 more
openaire   +3 more sources

The relationship between the cannabinoids and cardiac remodelling: A comprehensive review of pivotal mechanisms and emerging evidence

British Journal of Pharmacology, EarlyView.
Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska, Marta Baranowska‐Kuczko, Hanna Kozłowska   +2 more
wiley   +1 more source

N6-methyladenosine-modified miR-873 promotes receptor-interacting protein kinase 3-mediated necroptosis after intracerebral hemorrhage in mice and HT22 cells. [PDF]

Neuroreport
Wang J, Wang S, Wu X, Lu B, Huang J, Yu D, Zhao S, Chu Z, Yao Y, Xu Y.   +9 more
europepmc   +1 more source

LCN2‐ACOD1 Signalling Affects the Post‐Injury Regeneration of Skeletal Muscle Through Mediating Ferroptosis

Cell Proliferation, EarlyView.
LCN2 mediates the suppression of C2C12 myoblast proliferation and myotube formation via erastin‐induced ferroptosis. Mechanistically, the LCN2‐ACOD1 axis regulates skeletal muscle growth via mitochondria‐associated ferroptosis, providing a theoretical basis for the prevention and therapy of muscle‐related diseases.
Xiaojing Hao, Hongwei Shi, Di Wu, Rui Liang, Tong Zhao, Wen Sun, Yue Wang, Xiuju Yu, Xiaomao Luo, Yi Yan, Jiayin Lu, Haidong Wang, Juan Wang   +12 more
wiley   +1 more source

Immune Aging as a Failure of Programmed Cell Death Coordination. [PDF]

Int J Mol Sci
Lee HM, Kim EJ, Hasan A, Kang TB.
europepmc   +1 more source

Interferon-induced necroptosis [PDF]

Nature Immunology, 2013
openaire   +1 more source

Multiplexed Transcriptomics for Screening Drug Combinations and Defining the Mechanism of Action of HCC Therapeutics at Single‐Cell Resolution

Cell Proliferation, EarlyView.
We designed a framework for screening clinical drug combinations with anti‐hepatocellular carcinoma (HCC) activity, comprising four parts: primary screening, single‐cell screening, functional validation, and mechanism research. High‐throughput single‐cell screening identifies HY (HHT and YM155) as a potent anti‐HCC drug combination, validated by in ...
Mengmeng Jiang, Haide Chen, Guoxia Wen, Yuqing Mei, Wenzhao Zhou, Bin Xu, Tingyue Zhang, Guangyan Li, Junqing Wu, Xiaoping Han, Xudong Fu, Guoji Guo, Jingjing Wang   +12 more
wiley   +1 more source

PANoptosis: a new perspective for targeting programmed cell death after spinal cord injury. [PDF]

Front Immunol
Qian Q, Shi L, Xie J, Zhao X, Meng X.
europepmc   +1 more source

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, EarlyView.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Loss of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis. [PDF]

Cell Death Dis
Nemade H, Mehrkens D, Lottermoser HS, Yilmaz ZE, Mader J, Schelemei P, Picard FR, Geißen S, Schwab GF, Hoyer FF, Guthoff H, Hof A, Nettersheim FS, Sachinidis A, Gerdes N, Sengle G, Winkels H, Baldus S, Pasparakis M, Mollenhauer M, Adam M.   +20 more
europepmc   +1 more source