Results 201 to 210 of about 51,913 (289)

Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn’s disease [PDF]

, 2018
Ahmadian, Benowitz, Blumberg, Chen, Craig B. Wilen, Dermot P.B. McGovern, Feng Gao, Gabriel Nunez, Gerard E. Kaiko, Guo, Justin T. Kern, Kelli L. VanDussen, Liu, Liu, Michael J. Holtzman, Michael W. Rajala, Patel, Richard D. Head, Roberta Caruso, Shanshan Xiong, Ta-Chiang Liu, Thaddeus S. Stappenbeck   +21 more
core   +2 more sources

Opposing roles of DGAT‐mediated lipid droplet biogenesis in the regulation of ferroptosis sensitivity

The FEBS Journal, EarlyView.
Ferroptosis is driven by unrestricted peroxidation of polyunsaturated fatty acyl (PUFA) chains in membrane phospholipids. In triple‐negative breast cancer cells, lipid droplets (LDs) sequester dietary PUFAs, limiting their incorporation into membrane phospholipids, preventing mitochondrial damage, and reducing lipid peroxidation and ferroptosis.
Ana Kump, Leja Perne, Špela Koren, Eva Jarc Jovičić, Nastja Feguš, Carina Pinto Kozmus, Michele Wölk, Kristyna Brejchova, Maria Fedorova, Ondrej Kuda, Toni Petan   +10 more
wiley   +1 more source

The role of necroptosis in adiposity-based chronic disease (ABCD): A review. [PDF]

Medicine (Baltimore)
Wu Y, Bai J, Ma G.
europepmc   +1 more source

ADAM17 and its proteolytic targets in disease pathogenesis

The FEBS Journal, EarlyView.
ADAM17 as a multifunctional sheddase with contrasting roles across inflammatory, metabolic, cardiovascular, and neoplastic diseases. Through regulated activation by iRhom, iTAP/FRMD8, and tetraspanins, ADAM17 cleaves diverse membrane ligands and receptors, thereby promoting inflammation, fibrosis, obesity, insulin resistance, and tumor progression ...
Abdulbasit Amin, Marina Badenes
wiley   +1 more source

Unlocking glioma vulnerabilities: targeting regulated cell death pathways for innovative therapies. [PDF]

Cell Death Discov
Guo J, Zong L, Huang Y, Liu X, Hu Y, Liu Y.   +5 more
europepmc   +1 more source

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source

RIPK3-driven phosphorylation of MFN2 orchestrates endoplasmic reticulum-mitochondria interaction and cardiomyocyte stress responses. [PDF]

Redox Biol
Wang Y, Xu T, Li Q, Ye L, Wang P, Wang P, Song Y, Ao X, Wang J, Ding W.   +9 more
europepmc   +1 more source

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

vIRA Inhibition of Antiviral Necroptosis and RIPK3 Binding Are Separable Events. [PDF]

Pathogens
Ragan KB, Sridharan H, Stark AS, Ilami K, Fisher AD, Brahms ON, Kaiser WJ, Upton JW.   +7 more
europepmc   +1 more source

Cardioprotective effects of prolyl hydroxylase inhibitors during reperfusion in myocardial infarction: A study using cardiosphere‐derived cells

Experimental Physiology, EarlyView.
Abstract Cardiosphere‐derived cells (CDCs) are a promising in vitro model for studying myocardial ischaemia–reperfusion (I–R) injury and testing potential therapeutic interventions. This study investigated the suitability of CDCs as a model for myocardial infarction (MI) and the effects of prolyl hydroxylase inhibitor (PHI) administration during ...
Luca Salhöfer, Ulrike B. Hendgen‐Cotta, Joachim Fandrey, Timm Schreiber, Tristan Leu   +4 more
wiley   +1 more source