Results 221 to 230 of about 60,497 (319)

Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn’s disease [PDF]

, 2018
Ahmadian, Benowitz, Blumberg, Chen, Craig B. Wilen, Dermot P.B. McGovern, Feng Gao, Gabriel Nunez, Gerard E. Kaiko, Guo, Justin T. Kern, Kelli L. VanDussen, Liu, Liu, Michael J. Holtzman, Michael W. Rajala, Patel, Richard D. Head, Roberta Caruso, Shanshan Xiong, Ta-Chiang Liu, Thaddeus S. Stappenbeck   +21 more
core   +2 more sources

Nitrate Prevents Sjögren's Disease by Modulating T Helper Cells via NF‐κB Pathway Suppression

Oral Diseases, EarlyView.
ABSTRACT Objective Sjögren's disease (SjD) is a chronic autoimmune disease characterized by abnormal T helper (Th) cell distribution in the salivary glands (SGs). Although nitrate can regulate immune responses and preserve SGs function, its preventive effects on SjD remain unexplored.
Conglin Du, Zi Yang, Yang Yang, Chunmei Zhang, Hideaki Kagami, Xianqi Li, Liang Hu, Junji Xu, Jian Zhou   +8 more
wiley   +1 more source

Immune involvement in neuropsychiatric disorders: Insights from single‐cell transcriptomic studies

Psychiatry and Clinical Neurosciences, EarlyView.
Neuropsychiatric disorders pose profound challenges to both research and treatment, largely due to their clinical heterogeneity and the limited understanding of their underlying biological mechanisms. While bulk RNA sequencing (bulk RNA‐seq) has been widely used to study gene expression, it cannot resolve cell‐type‐specific signals or detect rare ...
Tsutomu Takeda, Michihiro Toritsuka, Hiroto Tamakoshi, Nakao Iwata, Manabu Makinodan   +4 more
wiley   +1 more source

Computational identification of necroptosis-related hub genes and therapeutic targets in dilated cardiomyopathy via integrated analysis of bulk and single-cell RNA sequencing public cohorts. [PDF]

Medicine (Baltimore)
Xia M, Ji Y, Zhu H.
europepmc   +1 more source

Necroptosis in Nonalcoholic Steatohepatitis

Cellular and Molecular Gastroenterology and Hepatology, 2015
Jérémie Gautheron, PhD, Mihael Vucur, PhD, Tom Luedde MD,, PhD   +2 more
openaire   +3 more sources

Role of RIPK1/RIPK3/MLKL signalling pathway in sepsis‐associated acute kidney injury

Experimental Physiology, EarlyView.
Abstract Sepsis‐associated acute kidney injury (SA‐AKI) is a common clinical syndrome in critically ill patients, and its high mortality rate is closely related to complex pathological mechanisms. Existing studies have shown that the pathophysiological process of SA‐AKI involves complex multi‐mechanism interactions, including an uncontrolled systemic ...
Huijun Yin, Jingyi Wang, Huirong Han
wiley   +1 more source

The predictive value of necroptosis-related lncRNAs in prostate cancer prognosis and their potential to distinguish between cold and hot tumors. [PDF]

Front Cell Dev Biol
Zhang K, Li K, Deng J, Zhao C, Wang F, Xie J.   +5 more
europepmc   +1 more source

Impact of combined ginsenoside‐MC1 and irisin on mitochondrial apoptosis in diabetic rats with hepatic reperfusion injury: Role of AMPK/JNK signalling

Experimental Physiology, EarlyView.
Abstract Hepatic ischaemia–reperfusion (IR) injury is a serious clinical issue, especially in patients with type 2 diabetes mellitus (T2DM). As mitochondria play a critical role in the regulation of IR‐induced liver damage, mitochondria‐targeted treatment is of the utmost significance for improving outcomes.
Jie Lin, Lei Han, Zhigang Ma, Bo Yuan, Yabin Yu   +4 more
wiley   +1 more source

The CCL11-CCR3 Axis Regulates the Aggravation of Neuroinflammation in Astrocytic Necroptosis After Cerebral Ischemia. [PDF]

FASEB J
Yin H, Zhang X, Li M, Liu Y, Zhang Y, Zhang Y, Ci H, Li K, Yang S, Wang G, Zhang T.   +10 more
europepmc   +1 more source

Interferon-induced necroptosis [PDF]

Nature Immunology, 2013
openaire   +1 more source